Results 191 to 200 of about 867,008 (306)

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

CXCR4-tropic HIV-1 infection in an immunocompetent monkey model. [PDF]

Nat Commun
Meyerson NR, Bauer VL, Fattor WT, Warren CJ, Barbachano-Guerrero A, Weiss MJ, Dirasantha O, Burris BL, Adesina AS, Timpona JL, Feldman ER, Fahy RT, Gendler P, Fainberg A, Nehete PN, Shelton KA, Galvan A, Tustin GW, Koehle PJ, Salinas MD, Davila O, Lindemann EI, Clark SE, Garnett ML, DeMarco CT, Scianna SR, Denny TN, Kuhn JH, Aye PP, Veazey RS, Kezar SM, Wilkerson GK, Sawyer SL.   +32 more
europepmc   +1 more source

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

HIV-1-specific CD8⁺ T cells with different abilities to recognize HIV-1-infected cells in HIV-1-exposed seronegative individuals. [PDF]

PNAS Nexus
Nguyen HT, Chikata T, Kuse N, Zhang Y, Pham DTN, Do NT, Nguyen TC, Lung NB, Bui HTM, Gatanaga H, Van Tran G, Nguyen BT, Van Nguyen D, Giang LM, Oka S, Takiguchi M.   +15 more
europepmc   +1 more source

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

Decoding HIV-1 Next Move Through Matrix Protein p17 Quasi-Species. [PDF]

Microbiologyopen
Messali S, Bertelli A, Giovanetti M, Sclavi L, Ciccozzi M, Slevin M, Caruso A, Caccuri F.   +7 more
europepmc   +1 more source

Dried blood spot analysis in antidoping: Technical challenges, analytical advances, and future perspectives

Bulletin of the Korean Chemical Society, EarlyView.
Dried blood spot (DBS) analysis enables minimally invasive blood collection with strong analyte stability and simplified logistics, supporting anti‐doping applications beyond traditional matrices. Recent advances address hematocrit, volume variability, and matrix effects while expanding coverage to steroid esters, World Anti‐Doping Agency‐listed ...
Jihyun Yoon, Jiyeong Hong, Hanbin Oh, Chi Hwan Lee, Ki Hun Kim   +4 more
wiley   +1 more source

Reduction of the HIV-1 reservoir in T cells from people with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells. [PDF]

mBio
Checkley MA, Luttge BG, Cameron CM, Leskov KS, Dobrowolski C, Wald DN, McMahon D, Haidar G, Sobolewski MD, Enick PN, Cyktor J, Mellors JW, Karn J.   +12 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly. [PDF]

Proc Natl Acad Sci U S A
Gupta M, Waltmann C, Renner N, Wang Y, James LC, Jacques DA, Böcking T, Voth GA.   +7 more
europepmc   +1 more source