Results 51 to 60 of about 25,225,361 (379)

Focus on chirality of HIV-​1 non-​nucleoside reverse transcriptase inhibitors [PDF]

, 2016
Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug resistant mutant strains.
Famiglini, Valeria, Silvestri, Romano
core   +2 more sources

Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages

Retrovirology, 2019
Background Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression.
Shringar Rao, Raquel Amorim, Meijuan Niu, Yann Breton, Michel J. Tremblay, Andrew J. Mouland   +5 more
doaj   +1 more source

The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter. [PDF]

, 2019
A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying and eradicating persistent reservoirs of replication-competent provirus.
Chang, Kungyen, Chao, Ti-Chun, Karris, Maile Ann Young, Kaul, Marcus, Li, Zhonghan, Qin, Yue, Rana, Tariq M, Sanchez, Ana, Singh, Gatikrushna, Tiwari, Shashi Kant, Yau, Edwin, Zhang, Qiong   +11 more
core   +1 more source

Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study

PLoS ONE, 2015
Introduction The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and
Daniel D. Murray, Kazuo Suzuki, M. Law, J. Trebicka, J. Neuhaus, D. Wentworth, M. Johnson, M. Vjecha, A. Kelleher, S. Emery   +9 more
semanticscholar   +1 more source

Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques. [PDF]

, 2019
The microbiome is an integral and dynamic component of the host and is emerging as a critical determinant of immune responses; however, its influence on vaccine immunogenicity is largely not well understood.
Dinasarapu, Ashok R, Durbin-Johnson, Blythe P, Elizaldi, Sonny R, Iyer, Smita S, Kozlowski, Pamela A, Raeman, Reben, Rolston, Matthew, Settles, Matthew, Verma, Anil, Walter, Korey A   +9 more
core   +1 more source

Genetic diversity and drug resistance mutations of HIV-1 in Leningrad Region

Журнал микробиологии, эпидемиологии и иммунобиологии, 2022
Introduction. The spread of the human immunodeficiency virus type 1 (HIV-1) has become a global concern and has approached the pandemic status. St.
A. N. Shchemelev, A. V. Semenov, Yu. V. Ostankova, E. B. Zueva, D. E. Valutite, D. A. Semenova, V. S. Davydenko, A. A. Totolian   +7 more
doaj   +1 more source

Lenacapavir: a first-in-class HIV-1 capsid inhibitor.

Current Opinion in HIV and AIDS, 2022
PURPOSE OF REVIEW This review summarizes available data for lenacapavir, an investigational first-in-class agent that disrupts functioning of HIV capsid protein across multiple steps in the viral life cycle.
H. Dvory‐Sobol, Naveed A Shaik, C. Callebaut, M. Rhee   +3 more
semanticscholar   +1 more source

Detection of HIV-1 infection in dried blood spots from a 12-year-old ABO bedside test card [PDF]

, 1998
Background and Objectives: We tested dried blood from an ABO bedside test card which had been stored at room temperature for 12 years, to prove that a patient with HIV-1 infection had been infected by blood transfusion. Materials and Methods: Immunoblots
Eberle, J., Emminger, Ch., Gürtler, L., Mayer, G., Strobel, Erwin   +4 more
core   +1 more source

Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection [PDF]

, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Borrow, Persephone, Chain, Benjamin M., Groppelli, Elisabetta, Jolly, Clare, Pellegrino, Pierre, Williams, Ian, Zhang, Changwang, Zhou, Shi   +7 more
core   +4 more sources

Study of the specific toxic effects of the substance 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil, the original non-nucleoside inhibitor of human immunodeficiency virus type 1 (Retroviridae; Orthoretrovirinae; Lentivirus: Human immunodeficiency virus 1) reverse transcriptase

Вопросы вирусологии, 2021
Introduction. Combination antiretroviral therapy is currently the main component of treatment for human immunodeficiency virus (HIV) infected patients.
E. A. Gaidai, K. L. Kryshen, E. A. Jain (Korsakova), D. V. Demchenko, D. R. Kargopol’tseva, A. E. Katel’nikova, D. S. Gaidai, V. Yu. Balabanyan   +7 more
doaj   +1 more source