Results 61 to 70 of about 658,368 (320)

RNA Control of HIV-1 Particle Size Polydispersity [PDF]

PLoS ONE 1, 9 (2014) e83874, 2014
HIV-1, an enveloped RNA virus, produces viral particles that are known to be much more heterogeneous in size than is typical of non-enveloped viruses. We present here a novel strategy to study HIV-1 Viral Like Particles (VLP) assembly by measuring the size distribution of these purified VLPs and subsequent viral cores thanks to Atomic Force Microscopy ...
arxiv   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading?

Viruses
Worldwide, almost 40 million people are currently living with HIV-1. The implementation of cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently infected cells.
Ana Luiza Abdalla, Gabriel Guajardo-Contreras, Andrew J. Mouland   +2 more
doaj   +1 more source

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection [PDF]

Open Biology, 2016
The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription.
Kristin Höhne, Ramona Businger, Anouk van Nuffel, Sebastian Bolduan, Herwig Koppensteiner, Ann Baeyens, Jolien Vermeire, Eva Malatinkova, Bruno Verhasselt, Michael Schindler   +9 more
doaj   +1 more source

Terahertz Metamaterial Sensors: Design Theory, Optimization Approach, and Advancements in Biosensing Applications

Advanced Materials Technologies, EarlyView.
This review provides an in‐depth overview of the design principles and optimization strategies for terahertz (THz) metamaterials (MMs) sensors based on the dielectric perturbation theory. Various structures and methods are explored to enhance sensor performance, focusing on improving sensitivity and Q‐factor.
Lei Cao, Shanshan Jia, Fanqi Meng, Merle Richter, Yannik Loth, Anna Katharina Wigger, Chenglin Yang, Liuyang Zhang, Peter Haring Bolívar, Hartmut G. Roskos   +9 more
wiley   +1 more source

Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1 [PDF]

arXiv, 2021
Broadly neutralizing antibodies (bNAbs) are promising targets for vaccination and therapy against HIV. Passive infusions of bNAbs have shown promise in clinical trials as a potential alternative for anti-retroviral therapy. A key challenge for the potential clinical application of bnAbs is the suppression of viral escape, which is more effectively ...
arxiv  

Chasing the Infecting HIV-1 [PDF]

Clinical Infectious Diseases, 2011
In the absence of an effective prophylactic vaccine and successful viral eradication strategies, the burden of human immunodeficiency virus type 1 (HIV-1) infection and disease continues to grow worldwide. The events characterizing primary HIV-1 infection and the early stages of the infection have been the focus of extensive research addressing the ...
Anna Maria Geretti, Anna Maria Geretti, Sabine Kinloch-de Loes   +2 more
openaire   +4 more sources

Optical Nanoscopy for Elucidating Nano–Bio Interactions: A One Health Perspective

Advanced Optical Materials, EarlyView.
The review comprehensively summarizes the application of far‐field fluorescence nanoscopy for the characterization of nanomaterial interactions with biological systems at the single‐particle and molecular scale, with an accent on their impact on human and ecosystem health.
Elisa De Luca, Chiara Coricciati, Marcella Trombetta, Giuseppe Gigli, Pamela Mozetic, Alberto Rainer   +5 more
wiley   +1 more source

Development of a droplet digital polymerase chain reaction assay for the sensitive detection of total and integrated HIV-1 DNA

Chinese Medical Journal
. Background:. Total human immunodeficiency virus (HIV) DNA and integrated HIV DNA are widely used markers of HIV persistence. Droplet digital polymerase chain reaction (ddPCR) can be used for absolute quantification without needing a standard curve ...
Lin Yuan, Zhiying Liu, Xin Zhang, Feili Wei, Shan Guo, Na Guo, Lifeng Liu, Zhenglai Ma, Yunxia Ji, Rui Wang, Xiaofan Lu, Zhen Li, Wei Xia, Hao Wu, Tong Zhang, Bin Su, Yanjie Yin   +16 more
doaj   +1 more source

The HIV-1 Vaccine Race [PDF]

Cell, 2002
There is an urgent need to come up with a vaccine that will curtail the spread of HIV-1. To be successful, the scientific community must work in concert to develop sound strategies based on a deeper understanding of the virus. Significant technological advances are also required to overcome the unique obstacles posed by HIV-1. Some of the challenges we
Yaoxing Huang, David D. Ho
openaire   +3 more sources