Results 81 to 90 of about 25,225,361 (379)

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Nature, 2011
Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral therapies and linking innate virus detection to antiviral adaptive immune responses.
Kasia Hrecka, Caili Hao, M. Gierszewska, Selene K Swanson, Małgorzata Kęsik-Brodacka, Smita Srivastava, L. Florens, M. Washburn, J. Skowroński   +8 more
semanticscholar   +1 more source

altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. [PDF]

, 2018
The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule.
Genebat González, Miguel, Leal Noval, Manuel, Ruiz-Mateos Carmona, Ezequiel, Tarancon Diez, Laura   +3 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Age, sex, income, sociodemographic and health system inequalities in the global burden of high systolic blood pressure: an analysis of the Global Burden of Disease Study 2021

BMJ Open
Objectives To examine the global and regional trends in disparities of high systolic blood pressure (HSBP) burden between 1990 and 2021 by age, sex, sociodemographic index and health systems’ performance.Design Systematic analysis.Setting Global ...
Hamid Sharifi, Seyed Aria Nejadghaderi, Azin Kadkhodamanesh, Mohammad-Mahdi Bastan, Meraj Sharifi   +4 more
doaj   +1 more source

Second European Round Table on the Future Management of HIV

Journal of Virus Eradication, 2015
The Second European Round Table on the Future Management of HIV took place in Barcelona, 10–11 October 2014 and focused on the HIV-1 reservoir, strategies for HIV cure and primary HIV infection (PHI).
Casper Rokx, Douglas D. Richman, Michaela Müller-Trutwin, Guido Silvestri, Jan Lunzen, van, Saye Khoo, Mathias Lichterfeld, Marcus Altfeld, Carlo Federico Perno, Peter W. Hunt, Paddy Mallon, Jürgen K. Rockstroh, Anton L. Pozniak, Bonaventura Clotet, Charles A.B. Boucher   +14 more
doaj   +1 more source

Defective proviruses rapidly accumulate during acute HIV-1 infection

Nature Network Boston, 2016
Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4+ T cells in a latent form that is not targeted by the immune system or by ART.
Katherine M. Bruner, Alexandra J Murray, Ross A. Pollack, M. Soliman, S. Laskey, A. Capoferri, J. Lai, M. Strain, S. Lada, R. Hoh, Y. Ho, D. Richman, S. Deeks, J. Siliciano, R. Siliciano   +14 more
semanticscholar   +1 more source

Chasing the Infecting HIV-1 [PDF]

Clinical Infectious Diseases, 2011
In the absence of an effective prophylactic vaccine and successful viral eradication strategies, the burden of human immunodeficiency virus type 1 (HIV-1) infection and disease continues to grow worldwide. The events characterizing primary HIV-1 infection and the early stages of the infection have been the focus of extensive research addressing the ...
Anna Maria Geretti, Anna Maria Geretti, Sabine Kinloch-de Loes   +2 more
openaire   +5 more sources

Characterization of the longitudinal HIV-1 quasispecies evolution in HIV-1 infected individuals co-infected with Mycobacterium tuberculosis [PDF]

, 2010
One of the earliest and most striking observations made about HIV is the extensive genetic variation that the virus has within individual hosts, particularly in the hypervariable regions of the env gene which is divided into 5 variable regions (V1-V5 ...
Leulebirhan, Tsigereda Biru
core  

Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study [PDF]

, 2008
Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form.
Barrett, Tracey, Liu, Juan, Schlauch, Karen, Wang, Weifeng, Wheeler, David, Wu, Yuntao, Yoder, Alyson, Yu, Dongyang   +7 more
core   +3 more sources