Results 121 to 130 of about 30,382,849 (226)

G140S/Q148R and N155H mutations render HIV-2 Integrase resistant to Raltegravir whereas Y143C does not

Retrovirology, 2011
Background HIV-2 is endemic in West Africa and has spread throughout Europe. However, the alternatives for HIV-2-infected patients are more limited than for HIV-1.
Damond Florence, Collin Gilles, Storto Alexandre, Charpentier Charlotte, Delelis Olivier, Ni Xiao-Ju, Descamps Diane, Mouscadet Jean-François   +7 more
doaj   +1 more source

Semaglutide improves MASLD and MASH in people with HIV: The SLIM LIVER study

HIV Medicine, Volume 27, Issue 10, Page 1710-1714, October 2026.
Abstract Objectives We have shown that semaglutide, a glucagon‐like peptide‐1 receptor agonist (GLP‐1RA), is a highly effective therapy for metabolic dysfunction‐associated steatotic liver disease (MASLD) in people with HIV (PWH). The OWLiver® metabolomics algorithms allow non‐invasive MASLD severity staging without liver biopsy, but the use of ...
Jordan E. Lake, Douglas W. Kitch, Amy Kantor, Rebeca Mayo, Pablo Belaunzaran‐Zamudio, Carl J. Fichtenbaum, Todd T. Brown, Kathleen E. Corey, Fred Sattler, Kristine M. Erlandson   +9 more
wiley   +1 more source

Computer tools in the discovery of HIV-1 integrase inhibitors

, 2010
Computer-aided drug design (CADD) methodologies have made great advances and contributed significantly to the discovery and/or optimization of many clinically used drugs in recent years.
Chenzhong Liao, Marc C Nicklaus
core   +1 more source

Detection of HIV-1 infection in dried blood spots from a 12-year-old ABO bedside test card [PDF]

, 1998
Background and Objectives: We tested dried blood from an ABO bedside test card which had been stored at room temperature for 12 years, to prove that a patient with HIV-1 infection had been infected by blood transfusion. Materials and Methods: Immunoblots
Mayer, G., Eberle, J., G. Mayer, L. Gürtler, Emminger, Ch., Strobel, Erwin, J. Eberle, Gürtler, L., E. Strobel, Ch. Emminger   +9 more
core   +1 more source

Potential benefit of dolutegravir once daily: efficacy and safety

HIV/AIDS: Research and Palliative Care, 2013
Alessandra Fantauzzi,1 Ombretta Turriziani,2 Ivano Mezzaroma11Department of Clinical Medicine, 2Department of Molecular Medicine, Sapienza, University of Rome, Rome, ItalyAbstract: The viral integrase enzyme has recently emerged as a primary alternative ...
Fantauzzi A, Turriziani O, Mezzaroma I
doaj  

Non-integrase mechanisms for dolutegravir resistance

Retrovirology
Background Antiretroviral inhibitors that target specific aspects of human immunodeficiency virus 1 (HIV-1) replication have made a huge impact on the management of the global AIDS pandemic and the health and well-being of people that live with HIV ...
Alan N. Engelman
doaj   +1 more source

Characteristics and management of low‐level viraemia in people living with HIV in a resource‐limited setting: A multicentre retrospective study in Greece

HIV Medicine, Volume 27, Issue 10, Page 1663-1669, October 2026.
Abstract Objectives Low‐level viraemia (LLV) persists in some people living with HIV despite antiretroviral therapy, raising concerns about virologic failure. We assessed the characteristics, management and outcomes of LLV in Greece, where next‐generation sequencing, therapeutic drug monitoring and electronic adherence monitoring are unavailable ...
Lydia Leonidou, Giota Lourida, Konstantinos Protopapas, Charalampos D. Moschopoulos, Dimitrios Zoulas, Charisis Totsikas, Dimitrios Basoulis, Elpida Mastrogianni, Apostolos Beloukas, Maria Lagadinou, Markos Marangos, Vasileios Papastamopoulos, Antonios Papadopoulos, Mina Psichogiou   +13 more
wiley   +1 more source

Development and application of non-integrating lentiviral vectors for gene therapy [PDF]

, 2009
Lentiviruses stably integrate their genome into the host genome. Although this feature can be advantageous for long term transgene expression, it also has the potential to cause mutagenesis and cell transformation.
Apolonia, L.F.S.
core  

Frailty and associated clinical factors among Japanese people with HIV: A multicentre cross‐sectional study using the revised Japanese Cardiovascular Health Study criteria

HIV Medicine, Volume 27, Issue 10, Page 1670-1681, October 2026.
Abstract Objectives Frailty is relevant to HIV care across middle and later life, yet Japanese data remain limited. We evaluated frailty, prefrailty and associated factors in Japanese people with HIV using the revised Japanese Cardiovascular Health Study (J‐CHS) criteria.
Hideta Nakamura, Julian Falutz, Taro Naka, Sho Miyamori, Nanae Ikemiyagi, Kazutaka Yamaniha, Shuhei Ideguchi, Rumi Minami, Masashi Narita, Michinori Shirano, Sei Samukawa, Tomoyuki Endo, Junji Imamura, Mayumi Imahashi, Shinichiro Ueda, Kazuko Yamamoto   +15 more
wiley   +1 more source

Alternaria alternata (Fr) Keissl Crude Extract Inhibits HIV Subtypes and Integrase Drug-Resistant Strains at Different Stages of HIV Replication

Pharmaceuticals
Background/Objectives: The development of HIV drug resistance to current antiretrovirals, and the antiretrovirals’ inability to cure HIV, provides the need of developing novel drugs that inhibit HIV-1 subtypes and drug-resistance strains.
Darian Naidu, Ernest Oduro-Kwateng, Mahmoud E. S. Soliman, Sizwe I. Ndlovu, Nompumelelo P. Mkhwanazi   +4 more
doaj   +1 more source