Results 121 to 130 of about 42,534 (266)

G140S/Q148R and N155H mutations render HIV-2 Integrase resistant to Raltegravir whereas Y143C does not

Retrovirology, 2011
Background HIV-2 is endemic in West Africa and has spread throughout Europe. However, the alternatives for HIV-2-infected patients are more limited than for HIV-1.
Damond Florence, Collin Gilles, Storto Alexandre, Charpentier Charlotte, Delelis Olivier, Ni Xiao-Ju, Descamps Diane, Mouscadet Jean-François   +7 more
doaj   +1 more source

Prevalence of resistance to integrase strand-transfer inhibitors (INSTIs) among untreated HIV-1 infected patients in Morocco

BMC Research Notes, 2018
Objective The integrase strand-transfer inhibitors (INSTIs) are an important class in the arsenal of antiretroviral drugs designed to block the integration of HIV-1 cDNA into the host DNA through the inhibition of DNA strand transfer.
Najwa Alaoui, Moulay Abdelaziz El Alaoui, Nadia Touil, Hicham El Annaz, Marouane Melloul, Reda Tagajdid, Naoufal Hjira, Mohamed Boui, El Mostapha El Fahime, Saad Mrani   +9 more
doaj   +1 more source

Potential benefit of dolutegravir once daily: efficacy and safety

HIV/AIDS: Research and Palliative Care, 2013
Alessandra Fantauzzi,1 Ombretta Turriziani,2 Ivano Mezzaroma11Department of Clinical Medicine, 2Department of Molecular Medicine, Sapienza, University of Rome, Rome, ItalyAbstract: The viral integrase enzyme has recently emerged as a primary alternative ...
Fantauzzi A, Turriziani O, Mezzaroma I
doaj  

Alternaria alternata (Fr) Keissl Crude Extract Inhibits HIV Subtypes and Integrase Drug-Resistant Strains at Different Stages of HIV Replication

Pharmaceuticals
Background/Objectives: The development of HIV drug resistance to current antiretrovirals, and the antiretrovirals’ inability to cure HIV, provides the need of developing novel drugs that inhibit HIV-1 subtypes and drug-resistance strains.
Darian Naidu, Ernest Oduro-Kwateng, Mahmoud E. S. Soliman, Sizwe I. Ndlovu, Nompumelelo P. Mkhwanazi   +4 more
doaj   +1 more source

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV‐1 Integrase [PDF]

, 2018
Susan E. Northfield, J. Wielens, Stephen J. Headey, Billy J. Williams‐Noonan, Mark D. Mulcair, M.J. Scanlon, Michael W. Parker, Philip E. Thompson, David K. Chalmers   +8 more
openalex   +1 more source

Retrotransposon Tto1: functional analysis and engineering for insertional mutagenesis [PDF]

, 2011
Retrotransposons are genomic parasites activated by stress conditions that can be seriously detrimental for their host. In this work I demonstrate that Tto1, a typical plant LTR retrotransposon with insertion preference into genes can be turned into a ...
Tramontano, Andrea, Tramontano, Andrea, Tramontano, Andrea   +2 more
core  

Halogen Bonding in Nucleic Acid Complexes

, 2017
Halogen bonding (X-bonding) has attracted notable attention among noncovalent interactions. This highly directional attraction between a halogen atom and an electron donor has been exploited in knowledge-based drug design. A great deal of information has
Kolář, Michal H., Tabarrini, Oriana
core   +1 more source

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase [PDF]

, 2013
Peter K. Quashie, Thibault Mésplède, Ying-Shan Han, Tamar Veres, Nathan Osman, Said Hassounah, Richard D. Sloan, Hong-Tao Xu, Mark A. Wainberg   +8 more
openalex   +1 more source

Diterima: 8 April 2013 Direvisi: 6 Mei 2013 Disetujui: 20 Agustus 2013 59 Kloning Fragmen DNA Pengkode Integrase (Int) HIV (Human Immunodeficiency Virus) 1 Pada Escherichia Coli JM109 [PDF]

, 2013
Human Immunodeficiency Virus (HIV) is an RNA virus. It is a lentivirus, a retrovirus member family which causes Acquired Immunodeficiency Syndrome (AIDS).
Hutapea, H. (Hotma), Oktavian, A. (Antonius)   +1 more
core  

Modeling the Late Steps in HIV-1 Retroviral Integrase-catalyzed DNA Integration [PDF]

, 2000
Elena Brin, Jizu Yi, Anna Marie Skalka, Jonathan Leis   +3 more
openalex   +1 more source