Results 131 to 140 of about 30,382,849 (226)

Effect of early antiretroviral therapy during primary HIV-1 infection on cell-associated HIV-1 DNA and plasma HIV-1 RNA

, 2011
BACKGROUND: Early initiation of combination antiretroviral therapy (ART) during primary HIV-1 infection may prevent the establishment of large viral reservoirs, possibly resulting in improved control of plasma viraemia rebound after ART cessation ...
Niederoest, B, Fischer, M., Battegay, Manuel, Günthard, Huldrych F, Fischer, M, Gianella, S., Weber, R, Vernazza, P, Cavassini, M., Gianella, S, Swiss HIV Cohort Study,, Bernasconi, E, Cavassini, M, Battegay, M., Vernazza, P., Joos, B., Rauch, A., Bernasconi, Enos, Weber, R., von Wyl, Viktor, Günthard, Huldrych F., Niederoest, B., Rauch, A, von Wyl, V., Hirschel, Bernard, Rauch, Andri, Joos, B, Günthard, H.F., Joos, Beda, Günthard, H F, Hirschel, B, Gianella, Sara, Niederoest, Barbara, Vernazza, Pietro, Battegay, M, Fischer, Marek, Weber, Rainer, von Wyl, V, Hirschel, B., Cavassini, Matthias, Bernasconi, E.   +40 more
core   +1 more source

4-​Hydroxy-​5-​pyrrolinone-​3-​carboxamide HIV-​1 integrase inhibitors

, 2008
The viral enzyme integrase is essential for the replication of HIV-1 and, after the discovery of IsentressTM, represents a validated target for anti-retroviral therapy.
Pace, Paola, Summa V, Spieser, Stephane A. H.   +4 more
core   +1 more source

von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.

, 2007
International audienceHIV-1 integrase, the viral enzyme responsible for provirus integration into the host genome, can be actively degraded by the ubiquitin-proteasome pathway. Here, we identify von Hippel-Lindau binding protein 1(VBP1), a subunit of the
Rain, Jean-Christophe, Dargemont, Catherine, Emiliani, Stéphane, Benarous, Richard, Mousnier, Aurélie; id_orcid, Massias-Simon, Aurélie, Ségéral, Emmanuel, Mousnier, Aurélie, Kubat, Nicole   +8 more
core   +1 more source

HIV-1 RNP from self-avoiding Gag models.

, 2019
Genomic RNA is shown in green, integrase in yellow and nucleocapsid in blue. The RNP with integrase tetramers is shown in the context of the HIV-1 capsid (PDB entry 3j3q, shown in red).
Andrew Jewett (6836663), Arthur J. Olson (832747), Stefano Forli (652121), David S. Goodsell (734981)   +3 more
core   +1 more source

Characterization of HIV-1 Integrase Reactions with Viral DNA [PDF]

, 2013
HIV-1 integrase (integrase) catalyzes the insertion of viral DNA into human chromosomes and is a focus for development of anti-integrase inhibitors to combat HIV infection. Integrase catalyzes two steps, a DNA-end cleavage reaction (3’-processing), and a
Kettlewell, Joanna
core  

IP-10 and MIG are sensitive markers of early virological response to HIV-1 integrase inhibitors. [PDF]

Front Immunol, 2023
Álvarez H, Gutiérrez-Valencia A, Mariño A, Saborido-Alconchel A, Calderón-Cruz B, Pérez-González A, Alonso-Domínguez J, Martínez-Barros I, Gallego-Rodríguez M, Moreno S, Aldamiz T, Montero-Alonso M, Bernal E, Galera C, Llibre JM, Poveda E.   +15 more
europepmc   +1 more source

Treatment Emergent Dolutegravir Resistance Mutations in Individuals Naïve to HIV-1 Integrase Inhibitors: A Rapid Scoping Review. [PDF]

Viruses, 2023
Tao K, Rhee SY, Chu C, Avalos A, Ahluwalia AK, Gupta RK, Jordan MR, Shafer RW.   +7 more
europepmc   +1 more source

Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase. [PDF]

Antimicrob Agents Chemother, 2023
Bonnard D, Le Rouzic E, Singer MR, Yu Z, Le Strat F, Batisse C, Batisse J, Amadori C, Chasset S, Pye VE, Emiliani S, Ledoussal B, Ruff M, Moreau F, Cherepanov P, Benarous R.   +15 more
europepmc   +1 more source

HIV-1 Integrase Strand Transfer Inhibitors and Neurodevelopment. [PDF]

Pharmaceuticals (Basel), 2022
Foster EG, Gendelman HE, Bade AN.
europepmc   +1 more source

Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. [PDF]

Sci Adv, 2023
Li M, Oliveira Passos D, Shan Z, Smith SJ, Sun Q, Biswas A, Choudhuri I, Strutzenberg TS, Haldane A, Deng N, Li Z, Zhao XZ, Briganti L, Kvaratskhelia M, Burke TR, Levy RM, Hughes SH, Craigie R, Lyumkis D.   +18 more
europepmc   +1 more source