Results 151 to 160 of about 30,382,849 (226)

Cooperation between HIV-1 integrase natural polymorphism K156N and 3'PPT mutations in dolutegravir monotherapy failure. [PDF]

J Antimicrob Chemother
van Osch JAT, Voermans JJC, Ouzerne H, Cromme ABH, Azugbene E, Voskamp M, Krullaars Z, Mahmud R, Overmars RJ, Gorska AU, Lungu C, van De Vijver DAMC, Gruters RA, van Kampen JJA, Mesplède T.   +14 more
europepmc   +1 more source

HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France). [PDF]

Pharmaceuticals (Basel), 2023
Sanna C, D'Abrosca B, Fiorentino A, Giammarino F, Vicenti I, Corona A, Caredda A, Tramontano E, Esposito F.   +8 more
europepmc   +1 more source

2-(Trihydroxyphenyl)thienopyrimidinones as Key Scaffolds for Targeting a Novel Allosteric Site of HIV-1 Integrase. [PDF]

Molecules
Tocco G, Laus A, Casula M, Caboni P, Beutler JA, Tramontano E, Esposito F.   +6 more
europepmc   +1 more source

Peptide inhibitors of HIV -1 integrase activity and dimerization

, 2005
Protein-protein interactions are increasingly being studied as targets for therapeutic intervention of many biological processes. However, the design of agents to disrupt these biologically important interactions is still in its infancy.
Zhao, Lei
core  

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir. [PDF]

mBio
Dinh T, Tber Z, Rey JS, Mengshetti S, Annamalai AS, Haney R, Briganti L, Amblard F, Fuchs JR, Cherepanov P, Kim K, Schinazi RF, Perilla JR, Kim B, Kvaratskhelia M.   +14 more
europepmc   +2 more sources

Erratum for Dinh et al., "The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir". [PDF]

mBio
Dinh T, Tber Z, Rey JS, Mengshetti S, Annamalai AS, Haney R, Briganti L, Amblard F, Fuchs JR, Cherepanov P, Kim K, Schinazi RF, Perilla JR, Kim B, Kvaratskhelia M.   +14 more
europepmc   +1 more source

A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors. [PDF]

Molecules, 2023
Mahajan PS, Smith SJ, Hughes SH, Zhao X, Burke TR.   +4 more
europepmc   +1 more source

Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding. [PDF]

Nat Commun
Jing T, Shan Z, Dinh T, Biswas A, Jang S, Greenwood J, Li M, Zhang Z, Gray G, Shin HJ, Zhou B, Passos D, Strutzenberg TS, Aiyer S, Andrade L, Zhang Y, Li Z, Craigie R, Engelman AN, Kvaratskhelia M, Lyumkis D.   +20 more
europepmc   +1 more source

Pi-pi stacking interactions with viral DNA contribute to the potency of naphthyridine-based HIV-1 integrase inhibitors. [PDF]

NAR Mol Med
Zhao XZ, Li M, Smith SJ, Karbasi A, Choudhuri I, Jing T, Lyumkis D, Craigie R, Burke TR.   +8 more
europepmc   +1 more source

GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants. [PDF]

Sci Adv, 2023
Aoki M, Aoki-Ogata H, Bulut H, Hayashi H, Takamune N, Kishimoto N, Tanaka H, Higashi-Kuwata N, Hattori SI, Das D, Venkateswara Rao K, Iwama K, Davis DA, Hasegawa K, Murayama K, Yarchoan R, Ghosh AK, Pau AK, Machida S, Misumi S, Mitsuya H.   +20 more
europepmc   +1 more source