Results 161 to 170 of about 42,534 (266)

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir. [PDF]

mBio
Dinh T, Tber Z, Rey JS, Mengshetti S, Annamalai AS, Haney R, Briganti L, Amblard F, Fuchs JR, Cherepanov P, Kim K, Schinazi RF, Perilla JR, Kim B, Kvaratskhelia M.   +14 more
europepmc   +2 more sources

2-(Trihydroxyphenyl)thienopyrimidinones as Key Scaffolds for Targeting a Novel Allosteric Site of HIV-1 Integrase. [PDF]

Molecules
Tocco G, Laus A, Casula M, Caboni P, Beutler JA, Tramontano E, Esposito F.   +6 more
europepmc   +1 more source

Identification and Optimization of a Novel HIV-1 Integrase Inhibitor. [PDF]

ACS Omega, 2022
Adu-Ampratwum D, Pan Y, Koneru PC, Antwi J, Hoyte AC, Kessl J, Griffin PR, Kvaratskhelia M, Fuchs JR, Larue RC.   +9 more
europepmc   +1 more source

Molecular Interactions between HIV-1 Integrase and the Two Viral DNA Ends within the Synaptic Complex that Mediates Concerted Integration

, 2009
Sibes Bera, Krishan K. Pandey, Ajaykumar C. Vora, Duane P. Grandgenett   +3 more
openalex   +2 more sources

Erratum for Dinh et al., "The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir". [PDF]

mBio
Dinh T, Tber Z, Rey JS, Mengshetti S, Annamalai AS, Haney R, Briganti L, Amblard F, Fuchs JR, Cherepanov P, Kim K, Schinazi RF, Perilla JR, Kim B, Kvaratskhelia M.   +14 more
europepmc   +1 more source

A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors. [PDF]

Molecules, 2023
Mahajan PS, Smith SJ, Hughes SH, Zhao X, Burke TR.   +4 more
europepmc   +1 more source

Fragment-Based Discovery of 8-Hydroxyquinoline Inhibitors of the HIV-1 Integrase–Lens Epithelium-Derived Growth Factor/p75 (IN–LEDGF/p75) Interaction

, 2013
Erik Serrao, Bikash Debnath, Hiroyuki Otake, Yuting Kuang, Frauke Christ, Zeger Debyser, Nouri Neamati   +6 more
openalex   +2 more sources

Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding. [PDF]

Nat Commun
Jing T, Shan Z, Dinh T, Biswas A, Jang S, Greenwood J, Li M, Zhang Z, Gray G, Shin HJ, Zhou B, Passos D, Strutzenberg TS, Aiyer S, Andrade L, Zhang Y, Li Z, Craigie R, Engelman AN, Kvaratskhelia M, Lyumkis D.   +20 more
europepmc   +1 more source

Pi-pi stacking interactions with viral DNA contribute to the potency of naphthyridine-based HIV-1 integrase inhibitors. [PDF]

NAR Mol Med
Zhao XZ, Li M, Smith SJ, Karbasi A, Choudhuri I, Jing T, Lyumkis D, Craigie R, Burke TR.   +8 more
europepmc   +1 more source

GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants. [PDF]

Sci Adv, 2023
Aoki M, Aoki-Ogata H, Bulut H, Hayashi H, Takamune N, Kishimoto N, Tanaka H, Higashi-Kuwata N, Hattori SI, Das D, Venkateswara Rao K, Iwama K, Davis DA, Hasegawa K, Murayama K, Yarchoan R, Ghosh AK, Pau AK, Machida S, Misumi S, Mitsuya H.   +20 more
europepmc   +1 more source