Results 111 to 120 of about 54,634 (147)
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Immune privilege and HIV‐1 persistence in the CNS
Immunological Reviews, 2006Summary: Human immunodeficiency virus‐1 (HIV‐1) neuroinvasion occurs early (during period of initial viremia), leading to infection of a limited amount of susceptible cells with low CD4 expression. Protective cellular and humoral immunity eliminate and suppress viral replication relatively quickly due to peripheral immune responses and the low level ...
Yuri, Persidsky, Larisa, Poluektova
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Current views on HIV-1 latency, persistence, and cure
Folia Microbiologica, 2016HIV-1 infection cannot be cured as it persists in latently infected cells that are targeted neither by the immune system nor by available therapeutic approaches. Consequently, a lifelong therapy suppressing only the actively replicating virus is necessary.
Zora, Melkova +3 more
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Persistent inapparent HIV-1 infection of human neuroblastoma cells
Archives of Virology, 1991We have studied human immunodeficiency virus type 1 (HIV-1) infection in three different human neuroblastoma cell lines; SK-N-MC, IMR-32 and SH-SY5Y. In all of these cell lines the infection became productive. However, the virus expression was different as determined by the p24 antigen capture assays from culture supernatants and immunochemical (APAAP)
M, Vesanen, T, Linna, A, Vaheri
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Persistent B19 parvovirus infections in hemophilic HIV‐1 infected patients
Journal of Medical Virology, 1995AbstractB19 infection can be acquired by transmission with blood factors in patients with congenital bleeding disorders, requiring clotting factor concentrates. In immunodeficient patients, the failure of immunity to clear B19 virus may produce persistent infections.
M Musiani +7 more
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Persistent non-gastrointestinal metabolic acidosis in pediatric HIV-1 infection
AIDS, 2003To determine the incidence and to identify the clinical parameters associated with non-gastrointestinal renal tubular and high anion gap acidosis in a cohort of HIV-1-infected children.Records of 202 HIV-1-infected children were reviewed to identify patients with metabolic acidosis.
Rana, Chakraborty +4 more
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Harnessing natural killer cells to target HIV-1 persistence
Current Opinion in HIV and AIDSPurpose of review The purpose of this article is to review recent advances in the role of natural killer (NK) cells in approaches aimed at reducing the latent HIV-1 reservoir. Recent findings Multiple approaches to eliminate cells harboring latent HIV-1 are being explored, but have ...
Vinita R, Joshi, Marcus, Altfeld
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The role of the viral glycoprotein in HIV-1 persistence
Immunology Letters, 1999The study of the immunological defects which arise from HIV infection has led to a deeper understanding both of the normal immune system and of the mechanisms by which it is damaged in disease. The interactions between viral and host factors during the early stages of HIV infection leads to a post-seroconversion steady state or 'set point' of viral RNA
J A, McKeating, P, Balfe
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CNS Persistence of HIV-1 in Children: the Untapped Reservoir
Current HIV/AIDS Reports, 2018The central nervous system (CNS) represents a potential HIV-1 reservoir that may need to be specifically targeted by remission strategies. Perinatally HIV-1-infected children and youth are exposed to HIV-1 at a critical period of brain development. This review summarizes the current literature regarding HIV-1 and the CNS in perinatal infection.HIV-1 ...
Ann, Chahroudi +2 more
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HIV-1 Myeloid Reservoirs — Contributors to Viral Persistence and Pathogenesis
Current HIV/AIDS ReportsHIV reservoirs are the main barrier to cure. CD4+ T cells have been extensively studied as the primary HIV-1 reservoir. However, there is substantial evidence that HIV-1-infected myeloid cells (monocytes/macrophages) also contribute to viral persistence and pathogenesis.Recent studies in animal models and people with HIV-1 demonstrate that myeloid ...
Edna A, Ferreira +2 more
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Two long terminal repeat circles and persistent HIV-1 replication
Current Opinion in Infectious Diseases, 2001Building on the success of combination antiretroviral drug therapy will require a better understanding of the underlying basis for viral persistence. Characterization of the therapeutic, viral, and immunological factors that influence the size and stability of viral reservoirs will foster the development of strategies to control or eliminate HIV-1 from
M E, Sharkey, M, Stevenson
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