Results 161 to 170 of about 178,048 (244)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Highly Potent Phosphinic HIV‑1 Protease Inhibitors: Synthesis, In Vitro Evaluation, and Docking Studies. [PDF]

ACS Omega
Hayat K, Qiu D, Wang Y, Imbenzi PS, Khan FI, Matziari M.   +5 more
europepmc   +1 more source

HIV-1 Protease as DNA Immunogen against Drug Resistance in HIV-1 Infection: DNA Immunization with Drug Resistant HIV-1 Protease Protects Mice from Challenge with Protease-Expressing Cells. [PDF]

Cancers (Basel), 2022
Petkov S, Kilpeläinen A, Bayurova E, Latanova A, Mezale D, Fridrihsone I, Starodubova E, Jansons J, Dudorova A, Gordeychuk I, Wahren B, Isaguliants M.   +11 more
europepmc   +1 more source

NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi, Xinwei Qiao, Yue Hu, Minjie Wang, Shaojie Yu, Zihan Gong, Yuxin Rao, Hui Zheng, Siting Chen, Lin Li, Rong Fu, Tao Liang, Jin Yao, Xiaobing Jiang, Junjun Li   +14 more
wiley   +1 more source

Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants. [PDF]

Eur J Med Chem
Kaur J, Spielvogel E, Nageswara Rao D, Rusere LN, Shaqra AM, Lockbaum GJ, Maryam A, Yilmaz NK, Swanstrom R, Schiffer CA, Ali A.   +10 more
europepmc   +1 more source

Prediction of HIV-1 protease resistance using genotypic, phenotypic, and molecular information with artificial neural networks. [PDF]

PeerJ, 2023
Tunc H, Dogan B, Darendeli Kiraz BN, Sari M, Durdagi S, Kotil S.   +5 more
europepmc   +1 more source

Dengue Virus Capsid Protein Interaction With Nucleic Acids

BioFactors, Volume 52, Issue 3, May/June 2026.
Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva, Ana S. Martins, Nina E. Karguth, Maria J. Sarmento, Francisco J. Enguita, Roland G. Huber, Ivo C. Martins, Nuno C. Santos   +7 more
wiley   +1 more source

High-throughput screening and characterization of novel inhibitors targeting HIV-1 protease precursor autoprocessing. [PDF]

Sci Rep
Jeep RH, Huang L, Ngo TA, Zeng FY, Boehlke J, Bennett L, Ashman S, Pass I, Chung TDY, Chen C.   +9 more
europepmc   +1 more source

Effectively predicting HIV-1 protease cleavage sites by using an ensemble learning approach. [PDF]

BMC Bioinformatics, 2022
Hu L, Li Z, Tang Z, Zhao C, Zhou X, Hu P.   +5 more
europepmc   +1 more source

Methods of Inner Filter Effect Correction in Fluorescence Measurements of Protein–Ligand Association: A Re‐Examination of the Association of Anti‐HIV Drugs to Serum Albumin

Chemistry–Methods, Volume 6, Issue 5, May 2026.
Fluorescence experiments to estimate the association constant avoiding the Inner Filter Effect on HSA titration with ligand. An excursus of the principal methodologies to identify and correct the IFE artifact. Fluorescence‐based methods are widely used to assess protein–ligand and protein–protein interactions.
Filippo Savini, Sara Bobone, Lorenzo Stella, Daniela Roversi, Alessio Bocedi   +4 more
wiley   +1 more source