Results 161 to 170 of about 136,889 (307)

Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro‐Inflammatory Responses via Modulation of JNK and NFkB Signaling

Glia, Volume 74, Issue 7, July 2026.
SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel, Rong Cheng, Christopher L. Cardona, Ellen Angeles, Gunjandeep Singh, Sabrina Miller, Archana Ashok, Andrew F. Teich, Angel Piriz, Aleyda Maldonado, Ivonne Z. Jiménez‐Velázquez, Richard Mayeux, Joseph H. Lee, Andrew A. Sproul   +13 more
wiley   +1 more source

Adherence to and effectiveness of Highly Active Antiretroviral Treatment for HIV infection: assessing the bidirectional relationship [PDF]

It is well-established that high adherence to HAART is a major determinant of virological and immunological success. Furthermore, psycho-social research has identified a wide range of adherence factors.
François Raffi, Bruno Spire, Maria Patrizia Carrieri, Christian Michelet, Luminita Schneider, Catherine Leport, Fidéline Collin, Karine Lamiraud, Jean-Paul Moatti, Camelia Protopopescu   +9 more
core  

Unintended Consequences of Life‐Saving Pharmaceutical Innovations: How HAART Led to the Resurgence of Syphilis

Health Economics, Volume 35, Issue 7, Page 1118-1130, July 2026.
ABSTRACT Syphilis, a sexually transmitted infection that can lead to serious health complications, was almost eliminated in the United States by 2000. But since then, its incidence began to increase, recently reaching a 60‐year peak. We suggest that the introduction of the highly active antiretroviral therapy (HAART) drug regimen, which transformed HIV
David Beheshti, Scott Cunningham, Nir Eilam   +2 more
wiley   +1 more source

Comparative study of armchair and zigzag graphene quantum dots as HIV-1 protease inhibitors. [PDF]

Sci Rep
Ibrahim A, Elhaes H, Ibrahim MA.
europepmc   +1 more source

HIV Care Retention and Cost Analysis in Multi‐Month ART Dispensing: A Randomized Controlled Trial in China

Journal of the International AIDS Society, Volume 29, Issue 7, July 2026.
ABSTRACT Introduction Multi‐month dispensing (MMD), as a differentiated service delivery model, can reduce the frequency of clinic visits, waiting time and travel costs for clinically stable people living with HIV. This study aimed to evaluate the impact of 6‐month MMD of antiretroviral therapy (ART) on retention and conduct a cost analysis in China ...
Wenqi Shang, Yanyan Zhu, Ying He, Xiaolin Li, Qinghai Hu, Hong Sun, Wenqing Geng, Hong Shang, Haibo Ding   +8 more
wiley   +1 more source

Mutational scan of self-cleavage by HIV-1 protease provides new views of a conformationally dynamic mechanism. [PDF]

J Virol
Nachum GS, Boucher JI, Flynn JM, Quansah P, Nachum S, Bolon DNA.   +5 more
europepmc   +1 more source

The evolution of the HIV-1 protease folding stability. [PDF]

Virus Evol, 2022
Ferreiro D, Khalil R, Gallego MJ, Osorio NS, Arenas M.   +4 more
europepmc   +1 more source

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity

MedComm, Volume 7, Issue 7, July 2026.
Regulatory B cells maintain immune homeostasis via suppressive cytokines and surface molecules like PD‐L1. While beneficially suppressing autoimmunity and promoting transplant tolerance, these identical mechanisms detrimentally attenuate antipathogen and antitumor immune responses.
Anni Feng, Qilong Li, Ning Jiang, Qijun Chen   +3 more
wiley   +1 more source

Structure-based pharmacophore modeling, high-throughput screening, and molecular dynamics identify a novel DrugBank-derived HIV-1 protease inhibitor. [PDF]

PLoS One
Khazaal Nazal AS, Rashid Alrashedi AM, Risan Al-Iessa LA, Ali Rabeea MAH.   +3 more
europepmc   +1 more source

Evolution of drug resistance drives destabilization of flap region dynamics in HIV-1 protease. [PDF]

Biophys Rep (N Y), 2023
Rajendran M, Ferran MC, Mouli L, Babbitt GA, Lynch ML.   +4 more
europepmc   +1 more source