Results 181 to 190 of about 136,889 (307)

Exact reaction coordinates for flap opening in HIV-1 protease. [PDF]

Proc Natl Acad Sci U S A, 2022
Wu S, Li H, Ma A.
europepmc   +1 more source

Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: A EuroSIDA study

, 2004
BACKGROUND: Factors that determine the immunological response to highly active antiretroviral therapy (HAART) are poorly defined. OBJECTIVE: Our aim was to investigate predictors of immunological failure after initial CD4(+) response.
Horban, A, Mocroft, Amanda, Dragsted, Ulrik Bak, Vella, S, Viard, JP, Lundgren, JD, Vella, Stefano, Viard, Jean-Paul, Machala, Ladislav, Hansen, ABE, Panos, G, Horban, Andrzej, Panos, George, Dragsted, UB, Lundgren, Jens Dilling, Mercey, D, Mocroft, A, Hansen, Ann-Britt E, Machala, L, Mercey, Danielle   +19 more
core  

Guidelines for Comparing Circular Dichroism Spectroscopy and Molecular Dynamics Simulations for Biomolecules

ChemPhysChem, Volume 27, Issue 12, 26 June 2026.
A direct comparison is made between circular dichroism (CD) spectroscopy and molecular dynamics (MD) simulations for studying peptide partitioning through biological membranes. The assumptions and limitations of each method is discussed, and case studies are provided for their use.
Cinzia Campus, Marta Roldo, Charles H. Chen, Roja Hadianamrei, Elisabetta Gavini, Christian Jorgensen   +5 more
wiley   +1 more source

Unveiling the Impact of Drug-Sensitive Mutations on HIV-1 Protease Dynamics: A Molecular Dynamics Simulation Study of the T12A, L63Q, and H69N Variants. [PDF]

Int J Mol Sci
Srihi H, Abid N, Fabeni L, Precone C, Déméné H, Chillemi G.   +5 more
europepmc   +1 more source

Evolving Mutational Buildup in HIV-1 Protease Shifts Conformational Dynamics to Gain Drug Resistance. [PDF]

J Chem Inf Model, 2023
Souffrant M, Yao XQ, Hamelberg D.
europepmc   +1 more source

Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Kinetic profiling of 172 compounds across KIT conformations—including D816V—reveals kinetic fingerprints that predict efficacy, selectivity, resistance, and inhibitors’ ability to stabilize key regulatory elements. Far from a secondary metric, binding kinetics provide mechanistic insights beyond affinity, offering a powerful framework for rational drug
Ana Corrionero, Niall Prendiville, Tatiana Cazorla, Maria Baena‐Nuevo, Röhm Sandra, Emilio Camafeita, Stefan Knapp, Patricia Alfonso   +7 more
wiley   +1 more source

Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants. [PDF]

Eur J Med Chem
Kaur J, Spielvogel E, Nageswara Rao D, Rusere LN, Shaqra AM, Lockbaum GJ, Maryam A, Yilmaz NK, Swanstrom R, Schiffer CA, Ali A.   +10 more
europepmc   +1 more source

HIV-1 Protease as DNA Immunogen against Drug Resistance in HIV-1 Infection: DNA Immunization with Drug Resistant HIV-1 Protease Protects Mice from Challenge with Protease-Expressing Cells. [PDF]

Cancers (Basel), 2022
Petkov S, Kilpeläinen A, Bayurova E, Latanova A, Mezale D, Fridrihsone I, Starodubova E, Jansons J, Dudorova A, Gordeychuk I, Wahren B, Isaguliants M.   +11 more
europepmc   +1 more source

Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status

International Journal of Cancer, Volume 158, Issue 12, Page 3268-3278, 15 June 2026.
What's new? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Klaus W. Fagerstedt, Sami Kilpinen, Johanna Arola, Benjamin Z. Sundqvist, Tom Böhling, Leif C. Andersson, Harri Sihto   +6 more
wiley   +1 more source

High-throughput screening and characterization of novel inhibitors targeting HIV-1 protease precursor autoprocessing. [PDF]

Sci Rep
Jeep RH, Huang L, Ngo TA, Zeng FY, Boehlke J, Bennett L, Ashman S, Pass I, Chung TDY, Chen C.   +9 more
europepmc   +1 more source