Novel Approaches for Investigating Host Responses to HIV Infection in Ex Vivo Human Genital Tissues
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Understanding local immune responses and the structural integrity of the genital mucosal barrier is essential for advancing knowledge of both susceptibility to sexual HIV transmission and the pathogenesis of chronic HIV infection. This review highlights innovative methodologies for investigating host responses to HIV infection using ex vivo ...
Mathias Franzén Boger +2 more
wiley +1 more source
Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies. [PDF]
Org Biomol ChemGhosh AK +10 more
europepmc +1 more source
Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik +3 more
wiley +1 more source
FMO-guided design of darunavir analogs as HIV-1 protease inhibitors. [PDF]
Sci RepChuntakaruk H +7 more
europepmc +1 more source
Anaerobe‐Driven Inflammation and Epithelial Barrier Disruption in Genital HIV Acquisition
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Background Genital microbiome dysbiosis is an important risk factor for the sexual acquisition of human immunodeficiency virus (HIV) in both the male and female genital tracts. The vaginal, penile and urethral mucosae are distinct microenvironments with characteristic microbiome compositions.
Shirley Constable +6 more
wiley +1 more source
Mechanism of drug resistance in HIV-1 protease subtype C in the presence of Atazanavir. [PDF]
Curr Res Struct BiolSankaran SV +3 more
europepmc +1 more source
Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Background Antiretroviral therapy (ART) suppresses HIV replication and protects people living with HIV (PLWH) from progressing to AIDS. However, despite ART, many PLWH experience chronic immune activation, which contributes to premature aging and non‐AIDS‐related comorbidities. One reason for this chronic immune activation (CIA) is HIV and its
Florian Hladik +5 more
wiley +1 more source
Liquid Chromatography-Mass Spectrometry Metabolomic Analysis of <i>Terminalia ferdinandiana</i> Exell. Fruit Extracts That Inhibit HIV-1 Cell Infection, HIV-1 Reverse Transcriptase and HIV-1 Protease. [PDF]
MoleculesCock IE, Matthews B, Basson AE.
europepmc +1 more source
The Clinical Respiratory Journal, Volume 20, Issue 5, May 2026.This case reports a 25‐year‐old allo‐HCT recipient with severe HCoV‐OC43 pneumonia who responded well to off‐label nirmatrelvir/ritonavir. It is the first such report that show the drug may benefit immunocompromised patients with this infection, though further studies are needed to confirm efficacy.
Mingzhou Zhang +5 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT In accordance with the Centers for Disease Control and Prevention recommendations, pregnant women and those with a recent pregnancy (i.e., lactating) are considered at high risk of developing severe COVID‐19 and qualify for treatment with nirmatrelvir/ritonavir.
Jacqueline Gerhart +7 more
wiley +1 more source