Results 211 to 220 of about 136,889 (307)

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

New Insights Into the Role of Neutrophils in Lymphoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
Tissue‐resident neutrophils challenge conventional paradigms by actively infiltrating normal lymphoid organs, predominantly localizing in interstitial compartments, a spatial distribution distinct from their classical vascular positioning. Neutrophils in lymphoid organs exhibit unique phenotypic and functional signatures, suggesting they play roles in ...
Ling Gu
wiley   +1 more source

Synthesis of Levoglucosenone‐Based Amphiphilic Molecules via Microwave‐Assisted Michael Additions

Chemistry–Methods, Volume 6, Issue 6, June 2026.
Comparison between the conventional and the sustainable synthetic microwave‐based approach for Michael addition reactions on LGO developed in this work. Aligning with the objectives of the EU chemicals strategy for sustainability, an ultrarapid, safe and sustainable method for producing a library of levoglucosenone (LGO)‐based amphiphilic molecules was
Maria Jose Calandri, Barbara Benedetti, Léa Charrier, Dinis O. Abranches, James R. Sherwood, Gareth O. Lloyd, João A. P. Coutinho, Con Robert McElroy, Alessandro Pellis   +8 more
wiley   +1 more source

Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands. [PDF]

Eur J Med Chem
Ghosh AK, Shaktah R, Ghosh AK, Johnson ME, Bhandari D, Amano M, Aoki M, Kovalevsky A, Mitsuya H.   +8 more
europepmc   +1 more source

Hydrogen Sulfide Rescues Microglia From HIV Tat‐Driven Ferroptosis: Implications for HIV‐Associated Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
HIV Tat induces ferroptosis and proinflammatory activation in microglia through iron accumulation and oxidative stress. Hydrogen sulfide donor NaHS suppresses HIV Tat‐induced ferroptosis by restoring redox balance, reinforcing the SLC7A11‐GPX4 axis, and attenuating microglial inflammation, highlighting hydrogen sulfide as a potential therapeutic ...
Aitizaz Ul Ahsan, Frida L. Martínez‐Cuevas, Elias Horanieh, Seema Singh, Uma Maheswari Deshetty, Palsamy Periyasamy, Shilpa Buch   +6 more
wiley   +1 more source

Pathway Specific Unbinding Free Energy Profiles of Ritonavir Dissociation from HIV-1 Protease. [PDF]

Biochemistry
Vig E, Sun J, Chang CA.
europepmc   +1 more source

Safety, Pharmacokinetics, and Dose Recommendations for Nirmatrelvir/Ritonavir in Individuals with Mild to Moderate COVID‐19 and Severe Renal Impairment

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1604-1613, June 2026.
Patients with severe renal impairment and COVID‐19 are at high risk for severe disease and death. Nirmatrelvir/ritonavir, an antiviral therapy for COVID‐19, is eliminated by renal excretion and can accumulate in patients with severe renal impairment.
Jacqueline Gerhart, Candace R. Bramson, Michelle Goulding, Haihong Shi, Olayide Oladoyinbo, Phylinda L. S. Chan, Sunring Chime, Jennifer Hammond   +7 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Darunavir Analogs as HIV-1 Protease Inhibitors. [PDF]

ACS Bio Med Chem Au
Ur Rehman MA, Chuntakaruk H, Amphan S, Suroengrit A, Hengphasatporn K, Shigeta Y, Rungrotmongkol T, Krusong K, Boonyasuppayakorn S, Aonbangkhen C, Khotavivattana T.   +10 more
europepmc   +1 more source

Chloroplast Genome Insights of Gleditsia japonica var. velutina and Evolutionary Implications for Variation and Phylogeny in Gleditsia

Ecology and Evolution, Volume 16, Issue 6, June 2026.
This study presents the first comprehensive chloroplast genome analysis of the critically endangered G. japonica var. velutina, providing essential insights into its evolutionary divergence within the genus Gleditsia and offering a critical genomic foundation for its conservation.
Shiyu Hu, Naiwei Li, Xingjian Liu, Baocheng Wu, Yueqi Sun, Mimi Li   +5 more
wiley   +1 more source

Triterpene esters from Uncaria rhynchophylla hooks as potent HIV-1 protease inhibitors and their molecular docking study. [PDF]

Sci Rep
Lee J.
europepmc   +1 more source