Subtype-Specific HIV-1 Protease and the Role of Hinge and Flap Dynamics in Drug Resistance: A Subtype C Narrative [PDF]
VirusesThe HIV-1 aspartic protease is an effective target for the treatment of HIV/AIDS. Current therapy utilizes a selection of nine protease inhibitors (PIs) in combination with other classes of antiretroviral drugs.
Dean Sherry +3 more
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Mechanism and Kinetics of HIV-1 Protease Activation [PDF]
VirusesThe HIV-1 protease is a critical enzyme for viral replication. Because protease activity is necessary to generate mature infectious virions, it is a primary target of antiretroviral treatment.
Caroline O. Tabler, John C. Tilton
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Dynamozones are the most obvious sign of the evolution of conformational dynamics in HIV-1 protease [PDF]
Scientific Reports, 2023 Proteins are not static but are flexible molecules that can adopt many different conformations. The HIV-1 protease is an important target for the development of therapies to treat AIDS, due to its critical role in the viral life cycle.
Mohammad Rahimi +2 more
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Towards designing of a potential new HIV-1 protease inhibitor using QSAR study in combination with Molecular docking and Molecular dynamics simulations [PDF]
PLoS ONE, 2023 Human Immunodeficiency Virus type 1 protease (HIV-1 PR) is one of the most challenging targets of antiretroviral therapy used in the treatment of AIDS-infected people. The performance of protease inhibitors (PIs) is limited by the development of protease
Mouna Baassi +6 more
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Premature Activation of the HIV-1 Protease Is Influenced by Polymorphisms in the Hinge Region [PDF]
VirusesHIV-1 protease inhibitors are an essential component of antiretroviral therapy. However, drug resistance is a pervasive issue motivating a persistent search for novel therapies.
Caroline O. Tabler +4 more
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Viruses, 2021 Fullerene derivatives with hydrophilic substituents have been shown to exhibit a range of biological activities, including antiviral ones. For a long time, the anti-HIV activity of fullerene derivatives was believed to be due to their binding into the ...
Ivana Křížová +10 more
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Low prevalence of hepatitis C co-infection in recently HIV-infected minority men who have sex with men in Los Angeles: a cross-sectional study. [PDF]
, 2015 BackgroundGeographic and sociodemographic characterization of hepatitis C virus (HCV) transmission amongst men who have sex with men (MSM) has been limited.
Bhattacharya, Debika +7 more
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Analysis of the conformations of the HIV-1 protease from a large crystallographic data set
Data in Brief, 2017 The HIV-1 protease performs essential roles in viral maturation by processing specific cleavage sites in the Gag and Gag-Pol precursor polyproteins to release their mature forms.
Luigi Leonardo Palese
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Viruses, 2022 Drug-resistance-associated mutation in essential proteins of the viral life cycle is a major concern in anti-retroviral therapy. M46I, a non-active site mutation in HIV-1 protease has been clinically associated with saquinavir resistance in HIV patients.
Nilottam Rana +8 more
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In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. [PDF]
, 2005 Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g ...
Back, DJ +9 more
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