Results 31 to 40 of about 136,889 (307)

No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial. [PDF]

PLoS ONE, 2013
Use of antiretroviral-based microbicides for HIV-1 prophylaxis could introduce a transmission barrier that inadvertently facilitates the selection of fitter viral variants among incident infections.
Denis R Chopera, Jaclyn K Mann, Philip Mwimanzi, Saleha Omarjee, Xiaomei T Kuang, Nonkululeko Ndabambi, Sarah Goodier, Eric Martin, Vivek Naranbhai, Salim Abdool Karim, Quarraisha Abdool Karim, Zabrina L Brumme, Thumbi Ndung'u, Carolyn Williamson, Mark A Brockman, CAPRISA 004 TRAPS Team   +15 more
doaj   +1 more source

Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration [PDF]

, 2005
Background The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate.Methods and ...
Wynhoven, B, Cane, P, Holguin, A, Pedro Cahn, Maria Belen Bouzas, Africa Holguin, Luis F Brigido, Sirivichayakul, S, Anne-Mieke Vandamme, Camacho, R, Efron, B, Koya Ariyoshi, Grossman, Z, Robert W Shafer, Shafer, RW, Bouzas, MB, Brian Wynhoven, Ricardo Camacho, Jonathan N Weber, Harrigan, PR, Ariyoshi, K, Ana Patricia Carvalho, Rosangela Rodrigues, Rudich, H, Candice Pillay, Soares, MA, Katzenstein, DA, Vandamme, AM, Clarke, J, Lynn Morris, Snoeck, J, Soriano, V, Rodrigues, R, Brigido, LF, Wataru Sugiura, Praphan Phanuphak, Kantor, R, Sugiura, W, John Clarke, Jonathan M Schapiro, Rami Kantor, David A Katzenstein, Carvalho, AP, P Richard Harrigan, Patricia Cane, Phanuphak, P, Brad Efron, Pillay, D, Pillay, C, Sunee Sirivichayakul, Joke Snoeck, Cahn, P, Hagit Rudich, Schapiro, JM, Morris, L, Zehava Grossman, Amilcar Tanuri, Tanuri, A, Weber, JN, Vincent Soriano, Deenan Pillay, Marcelo A Soares   +61 more
core   +1 more source

In silico prediction of mutant HIV-1 proteases cleaving a target sequence.

PLoS ONE, 2014
HIV-1 protease represents an appealing system for directed enzyme re-design, since it has various different endogenous targets, a relatively simple structure and it is well studied. Recently Chaudhury and Gray (Structure (2009) 17: 1636-1648) published a
Jan H Jensen, Martin Willemoës, Jakob R Winther, Luca De Vico   +3 more
doaj   +1 more source

Structural investigation of HIV-1 GP160 and gag-pol polyprotein recognition site with HIV-1 protease [PDF]

, 2022
HIV (human immunodeficiency virus) is an infectious virus that if left untreated can progress into AIDS (acquired immunodeficiency syndrome) and is a devastating and lethal disease with millions of related fatalities across the globe since its discovery.

core  

Prediction and molecular field view of drug resistance in HIV-1 protease mutants

Scientific Reports, 2022
Conquering the mutational drug resistance is a great challenge in anti-HIV drug development and therapy. Quantitatively predicting the mutational drug resistance in molecular level and elucidating the three dimensional structure-resistance relationships ...
Baifan Wang, Yinwu He, Xin Wen, Zhen Xi
doaj   +1 more source

Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection [PDF]

, 2004
The initial virus strains from as many as 12% of individuals with primary human immunodeficiency virus (HIV) infection have a 50% inhibitory concentration less than or equal to0.4-fold that of HIV type 1(NL4-3) (HIV-1(NL4-3)) to ritonavir ...
Joseph B. Margolick, Routy, JP, Susan J. Little, Frost, SDW, Leigh Brown, AJ, Connick, E, Little, SJ, Markowitz, M, Elizabeth Connick, Douglas D. Richman, Collier, AC, Richman, DD, Hellmann, NS, Brian Conway, Daar, ES, Good, B, Jacques Corbeil, Eric S. Daar, Margolick, JB, Simon D. W. Frost, Corbeil, J, Jean-Pierre Routy, Nicholas S. Hellmann, Benjamin Good, Viviana Simon, Simon, V, Ann C. Collier, Martin Markowitz, Conway, B, Andrew J. Leigh Brown   +29 more
core   +1 more source

Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]

, 2013
HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core   +1 more source

HIV-1 CRF 02 AG polymerase genes in Southern Ghana are mosaics of different 02 AG strains and the protease gene cannot infer subtypes

Virology Journal, 2009
Background Little is known about the detailed phylogeny relationships of CRF 02_AG HIV-1 polymerase genes in Ghana. The use of the protease gene of HIV-1 for subtyping has shown conflicting results. Methods The partial polymerase gene sequences of 25 HIV-
Sagoe Kwamena W, Dwidar Magda, Adiku Theophilus K, Arens Max Q   +3 more
doaj   +1 more source

Adaptive inhibitors of the HIV-1 protease

Progress in Biophysics and Molecular Biology, 2005
A significant obstacle to the efficacy of drugs directed against viral targets is the presence of amino acid polymorphisms in the targeted molecules. Amino acid polymorphisms may occur naturally due to the existence of variations within and between viral strains or as the result of mutations associated with drug resistance.
Hiroyasu, Ohtaka, Ernesto, Freire
openaire   +2 more sources

Antibacterial, Anti-HIV-1 Protease and Cytotoxic Activities of Aqueous Ethanolic Extracts from Combretum Adenogonium Steud. Ex A. Rich (Combretaceae). [PDF]

, 2012
\ud \ud Records have shown that Combretum adenogonium Steud. Ex A. Rich (Combretaceae) is used in traditional medicine systems of several tribes in Tanzania. This study focused on the investigation of antibacterial activity, anti-HIV-1 protease activity,
Innocent Ester, Mbwambo, Z.H., Mushi Novatus F, Mbwambo Zakaria H, Tewtrakul Supinya, Mushi, Novatus F, Mushi, N.F., Innocent, E., Innocent, Ester, Tewtrakul, Supinya, Tewtrakul, S., Mbwambo, Zakaria H   +11 more
core   +1 more source