Results 21 to 30 of about 136,889 (307)

Protease mediated maturation of HIV: Inhibitors of protease and the maturation process [PDF]

, 2012
Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol ...
Catherine S. Adamson, Adamson, Catherine S   +1 more
core   +1 more source

Mangiferin, an Anti-HIV-1 Agent Targeting Protease and Effective against Resistant Strains

Molecules, 2011
The anti-HIV-1 activity of mangiferin was evaluated. Mangiferin can inhibit HIV-1ⅢB induced syncytium formation at non-cytotoxic concentrations, with a 50% effective concentration (EC50) at 16.90 μM and a therapeutic index (TI) above 140. Mangiferin also
Rui-Rui Wang, Yue-Dong Gao, Chun-Hui Ma, Xing-Jie Zhang, Cheng-Gang Huang, Jing-Fei Huang, Yong-Tang Zheng   +6 more
doaj   +1 more source

Drug Resistance Mechanism of M46I-Mutation-Induced Saquinavir Resistance in HIV-1 Protease Using Molecular Dynamics Simulation and Binding Energy Calculation

Viruses, 2022
Drug-resistance-associated mutation in essential proteins of the viral life cycle is a major concern in anti-retroviral therapy. M46I, a non-active site mutation in HIV-1 protease has been clinically associated with saquinavir resistance in HIV patients.
Nilottam Rana, Atul Kumar Singh, Mohd Shuaib, Sanjay Gupta, Mahmoud M. Habiballah, Mustfa F. Alkhanani, Shafiul Haque, Mohd Salim Reshi, Shashank Kumar   +8 more
doaj   +1 more source

Towards designing of a potential new HIV-1 protease inhibitor using QSAR study in combination with Molecular docking and Molecular dynamics simulations

PLoS ONE, 2023
Human Immunodeficiency Virus type 1 protease (HIV-1 PR) is one of the most challenging targets of antiretroviral therapy used in the treatment of AIDS-infected people. The performance of protease inhibitors (PIs) is limited by the development of protease
Mouna Baassi, Mohamed Moussaoui, Hatim Soufi, Sanchaita Rajkhowa, Ashwani Sharma, Subrata Sinha, Said Belaaouad   +6 more
doaj   +2 more sources

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1 [PDF]

, 2005
Increased susceptibility to the protease inhibitors saquinavir and amprenavir has been observed in human immunodeficiency virus type 1 (HIV-1) with specific mutations in protease (V82T and N88S).
Wrin, T, Ruiz, L, Petropoulos, CJ, Clotet, B, Frost, SDW, Martinez-Picado, J, Leigh Brown, AJ, Parkin, NT   +7 more
core   +1 more source

Analysis of the conformations of the HIV-1 protease from a large crystallographic data set

Data in Brief, 2017
The HIV-1 protease performs essential roles in viral maturation by processing specific cleavage sites in the Gag and Gag-Pol precursor polyproteins to release their mature forms.
Luigi Leonardo Palese
doaj   +1 more source

Comparative analysis of the unbinding pathways of antiviral drug Indinavir from HIV and HTLV1 proteases by supervised molecular dynamics simulation.

PLoS ONE, 2021
Determining the unbinding pathways of potential small molecule compounds from their target proteins is of great significance for designing efficacious treatment solutions.
Farzin Sohraby, Hassan Aryapour
doaj   +1 more source

Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein

Viruses, 2021
Fullerene derivatives with hydrophilic substituents have been shown to exhibit a range of biological activities, including antiviral ones. For a long time, the anti-HIV activity of fullerene derivatives was believed to be due to their binding into the ...
Ivana Křížová, Alžběta Dostálková, Edison Castro, Jan Prchal, Romana Hadravová, Filip Kaufman, Richard Hrabal, Tomáš Ruml, Manuel Llano, Luis Echegoyen, Michaela Rumlová   +10 more
doaj   +1 more source

Cell Killing by HIV-1 Protease [PDF]

Journal of Biological Chemistry, 2003
The human immunodeficiency virus protease (HIV-1 PR) was expressed both in the yeast Saccharomyces cerevisiae and in mammalian cells. Inducible expression of HIV-1 PR arrested yeast growth, which was followed by cell lysis. The lytic phenotype included loss of plasma membrane integrity and cell wall breakage leading to the release of cell content to ...
Raquel, Blanco, Luis, Carrasco, Iván, Ventoso   +2 more
openaire   +2 more sources

The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage? [PDF]

, 2011
Background: Although being considered as a rarely observed HIV-1 protease mutation in clinical isolates, the L76V-prevalence increased 1998-2008 in some European countries most likely due to the approval of Lopinavir, Amprenavir and Darunavir which can ...
Braun, Patrick, Ehret Robert, Naeth, Gudrun, Frank Wiesmann, Tappe André, Tappe, André, Rolf Kaiser, Martin Stürmer, Hauke Walter, Jan Vachta, Walter, Hauke, André Tappe, Ehret, Robert, Stürmer Martin, Thomas Berg, Kaiser Rolf, Robert Ehret, Berg Thomas, Naeth Gudrun, Knechten Heribert, Gudrun Naeth, Patrick Braun, Knechten, Heribert, Stürmer, Martin, Wiesmann, Frank, Vachta, Jan, Heribert Knechten, Kaiser, Rolf, Berg, Thomas, Walter Hauke, Martin Däumer, Braun Patrick, Däumer Martin, Wiesmann Frank, Vachta Jan, Däumer, Martin   +35 more
core   +1 more source