Results 61 to 70 of about 136,889 (307)

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Detection of HIV-1 resistant to antiretroviral drugs among tomsk oblast population with newly diagnosed HIV-infection

Журнал инфектологии, 2020
The purpose of this paper is to evaluate the spreading of HIV-1 resistant to antiretroviral drugs among Tomsk Oblast population with newly diagnosed HIV-infection.Materials and methods.
D. P. Zyryanova, E. M. Astakhova, M. P. Gashnikova, T. N. Ismailova, E. F. Bocharov, A. S. Chernov, A. V. Totmenin, M. N. Gashnikova   +7 more
doaj   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Frequent intra-subtype recombination among HIV-1 circulating in Tanzania. [PDF]

, 2013
The study estimated the prevalence of HIV-1 intra-subtype recombinant variants among female bar and hotel workers in Tanzania. While intra-subtype recombination occurs in HIV-1, it is generally underestimated.
Kiwelu, Ireen E, Baca Jeannie, Vladimir Novitsky, Essex, M., Baca, Jeannie, Mary F McLane, Kapiga, Saidi H., Novitsky, Vladimir, Saidi H Kapiga, McLane, Mary F, M Essex, Ireen E Kiwelu, McLane, Mary, Essex, M, Jeannie Baca, Kiwelu Ireen E., Novitsky Vladimir, Manongi, Rachel, Manongi Rachel, Rachel Manongi, Kapiga, Saidi H, Margolin Lauren, Essex M., John Shao, Kiwelu, Ireen E., Noel Sam, Sam Noel, Lauren Margolin, McLane Mary F., Margolin, Lauren, Sam, Noel, Shao John, Kapiga Saidi H., Shao, John   +33 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Piperidine scaffold as the novel P2-ligands in cyclopropyl-containing HIV-1 protease inhibitors: Structure-based design, synthesis, biological evaluation and docking study.

PLoS ONE, 2020
A series of potent HIV-1 protease inhibitors, containing diverse piperidine analogues as the P2-ligands, 4-substituted phenylsulfonamides as the P2'-ligands and a hydrophobic cyclopropyl group as the P1'-ligand, were designed, synthesized and evaluated ...
Huiyu Zhou, Mei Zhu, Ling Ma, Jinming Zhou, Biao Dong, Guoning Zhang, Shan Cen, Yucheng Wang, Juxian Wang   +8 more
doaj   +1 more source

Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease

, 2013
Chemical enhancement: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates.
Hudson, H.R., Matthews, R.W., Nick J. Wardle, S. W. Annie Bligh, Ray W. Matthews, Wardle, N.J., Nunn, C., Vella, C., Bligh, S.W.A., Christine M. Nunn, Cherelyn Vella, Harry R. Hudson   +11 more
core   +1 more source

Adaptation to Different Human Populations by HIV-1 Revealed by Codon-Based Analyses [PDF]

, 2006
Several codon-based methods are available for detecting adaptive evolution in protein-coding sequences, but to date none specifically identify sites that are selected differentially in two populations, although such comparisons between populations have ...
Gravenor Michael B, Kosakovsky Pond, Sergei L., Sergei L Kosakovsky Pond, Michael B Gravenor, Michael Gravenor, Douglas D Richman, Frost Simon D. W, Richman Douglas D, Brown Andrew J. Leigh, Simon D W Frost, Zehava Grossman, Kosakovsky Pond Sergei L, Leigh Brown, Andrew J., Gravenor, Michael B., Andrew J Leigh Brown, Grossman, Z., Richman, D. D., Frost, S. D. W., Grossman Zehava   +18 more
core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Potential Associations of Mutations within the HIV-1 Env and Gag Genes Conferring Protease Inhibitor (PI) Drug Resistance

Microbiology Research, 2021
An increasing number of patients in Africa are experiencing virological failure on a second-line antiretroviral protease inhibitor (PI)-containing regimen, even without resistance-associated mutations in the protease region, suggesting a potential role ...
Ntombikhona F. Maphumulo, Michelle L. Gordon   +1 more
doaj   +1 more source