Results 71 to 80 of about 136,889 (307)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Molecular Docking Study of HIV-1 Protease with Triterpenoides Compounds from Plants and Mushroom [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2015
Background: Because of the reported high ability of virulence and medicinal resistance of HIV-1 virus during the last decades, many investigations have been performed concerning discovery and the introduction of anti-HIV-1 drugs.
Mokhtar Nosrati, Mandana Behbahani
doaj  

Early structural and functional changes of the vasculature in HIV-infected children: Impact of disease and antiretroviral therapy

, 2005
Background - Premature cardiovascular disease is increasingly recognized in HIV-infected patients, but the mechanisms involved are unclear. The purpose of this study was to determine the impact of HIV infection and antiretroviral therapy (ART) on markers
Clapson, Margaret, Halcox, Julian P., Donald, Ann E., Green, H, Halcox, JP, Deanfield, John E., Muriel Caslake, Charakida, M, Klein, Nigel J., Clapson, M, Caslake, M, Gibb, Diana M., Dunn, DT, Storry, C, Margaret Clapson, David T. Dunn, Clare Storry, Donald, AE, In Hiv-infected Children, Storry, Clare, Hannah Green, Green, Hannah, Diana M. Gibb, Nigel J. Klein, Gibb, DM, Klein, NJ, Deanfield, JE, Charakida, Marietta, Julian P. Halcox, Marietta Charakida, Caslake, Muriel, Ann E. Donald, Dunn, David T., John E. Deanfield   +33 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study [PDF]

, 2013
BACKGROUND: Non-adherence is one of the strongest predictors of therapeutic failure in HIV-positive patients. Virologic failure with subsequent emergence of resistance reduces future treatment options and long-term clinical success. METHODS: Prospective
Jürg Böni (36157), Yerly, Sabine, von Wyl Viktor, Alexandra Calmy (36005), Dunja Nicca (336117), Glass, Tracy R, Swiss HIV Cohort Study,, Hansjakob Furrer (93994), Günthard Huldrych F., Vincent Aubert (297526), Jürg Böni, Aubert Vincent, Calmy, Alexandra, Bucher, Heiner C, Huldrych F. Günthard (173082), Böni, J., Cavassini Matthias, Viktor von Wyl, Swiss HIV Cohort Study, Günthard, Huldrych F., Enos Bernasconi (174329), Furrer, Hansjakob, Heiner C Bucher, Klimkait, Thomas, Hansjakob Furrer, Alexandra Calmy, Calmy Alexandra, Aubert, Vincent, Glass, T.R., Sabine Yerly (82534), Dunja Nicca, Yerly, S., Bucher, Heiner C., Tracy R. Glass (134725), Yerly Ferrillo, Sabine, Bucher Heiner C., Tracy R Glass, Nicca, D., Bernasconi, E., Wainberg, Mark, Thomas Klimkait (178911), Calmy, A., Günthard, Huldrych F, Enos Bernasconi, Heiner C. Bucher (134728), Cavassini, M., Matthias Cavassini (146654), Aubert, V., Glass, Tracy R., Böni, Jürg, Klimkait Thomas, Thomas Klimkait, Glass Tracy R., Bernasconi, Enos, Nicca Dunja, von Wyl, Viktor, Nicca, Dunja, von Wyl, V., Furrer Hansjakob, Bernasconi Enos, Sabine Yerly, Furrer, H., Viktor von Wyl (146506), Günthard, H.F., Böni Jürg, Klimkait, T., Yerly Sabine, Vincent Aubert, Bucher, H.C., Huldrych F Günthard, Cavassini, Matthias, Matthias Cavassini   +71 more
core   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses [PDF]

, 2000
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263-272, KR WIILGLNK).
Anthony D. Kelleher, Jamie Wilson, Wayne Dyer, Sunil Shaunak, Phillips, Rodney, Sullivan, JS, Ian Jones, Workman, C, Rodney E. Phillips, Edward C. Holmes, Kelleher, AD, Christopher Conlon, Rachel L. Allen, John S. Sullivan, Conlon, C, Shaunak, S, Christian Brander, Kara Olson, Goulder, Philip, Allen, RL, Dyer, W, Olson, K, Graham Ogg, Brander, C, Philip Goulder, Mcmichael, Andrew, Ogg, G, Andrew J. McMichael, Long, C, Holmes, EC, Wilson, J, Goulder, P, Cassy Workman, Sarah Rowland-Jones, Rowland-Jones, S, McMichael, AJ, Jones, I, Phillips, RE, Chad Long   +38 more
core   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Subtype diversity and emergence of drug resistance in HIV-1 in solapur district of Maharashtra, India

Iranian Journal of Microbiology, 2022
Background and Objectives: Even after four decades, HIV infection remains a global challenge and a leading cause of mortality in adults across the world.
Dilip D. Karad, Ravi Tandon, Ajay Arya, Kailash D. Sonawane, Anusaya S. Chavan, Arun S. Kharat   +5 more
doaj  

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source