Bactericidal Immunity to Salmonella in Africans and Mechanisms Causing Its Failure in HIV Infection. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:Nontyphoidal strains of Salmonella are a leading cause of death among HIV-infected Africans. Antibody-induced complement-mediated killing protects healthy Africans against Salmonella, but increased levels of anti-lipopolysaccharide (LPS ...
Yun Shan Goh +11 more
doaj +1 more source
A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]
, 2013 The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I. +23 more
core +19 more sources
HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities. [PDF]
PLoS ONE, 2014 Many participants in microbicide trials remain uninfected despite ongoing exposure to HIV-1. Determining the emergence and nature of mucosal HIV-specific immune responses in such women is important, since these responses may contribute to protection and ...
Kelly E Seaton +15 more
doaj +1 more source
HIV-1/2 differentiation in a South African public laboratory
Southern African Journal of HIV Medicine, 2021 Background: The human immunodeficiency virus type-2 (HIV-2) prevalence in South Africa (SA) is unknown, however, sporadic cases have been reported.
Rendani T. Mafuyeka +3 more
doaj +1 more source
Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier
mBio, 2020 HIV-1 can cross the blood-brain barrier (BBB) to penetrate the brain and infect target cells, causing neurocognitive disorders as a result of neuroinflammation and brain damage.
Valérie Lorin +5 more
doaj +1 more source
Anti-HIV-1 ADCC and HIV-1 Env Can Be Partners in Reducing Latent HIV Reservoir
Frontiers in Immunology, 2021 BackgroundPersistence of HIV reservoir even in suppressive ART is the key obstacle in HIV-1 cure. We evaluated the ability of HIV-1 C Env to reactivate the latently infected resting memory CD4 cells and the ability of polyclonal HIV antibodies mediating ...
Poonam Suryawanshi +4 more
doaj +1 more source
Phage display selection of HIV specific conserved mimotopes with IgG from long-term non-progressors [PDF]
, 2005 Poster presentation Background The aim of this study is to identify conserved epitopes of HIV-1 neutralizing antibodies in polyclonal plasma from LTNP to finally derive vaccine candidates.
Antoni, Sascha +6 more
core +1 more source
HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells
Cell Reports, 2019 Summary: Mucosal immune responses to HIV-1 involve the recognition of the viral envelope glycoprotein (gp)160 by tissue-resident B cells and subsequent secretion of antibodies.
Cyril Planchais +15 more
doaj +1 more source
Detection of HIV-1 infection in dried blood spots from a 12-year-old ABO bedside test card [PDF]
, 1998 Background and Objectives: We tested dried blood from an ABO bedside test card which had been stored at room temperature for 12 years, to prove that a patient with HIV-1 infection had been infected by blood transfusion. Materials and Methods: Immunoblots
Eberle, J. +4 more
core +1 more source
Bispecific Antibodies Against HIV [PDF]
Cell, 2016 Synergistic bispecific antibodies against HIV exhibit extraordinary potency and breadth of neutralization as promising candidates for treatment and prevention.
openaire +2 more sources