Results 11 to 20 of about 2,450,636 (325)

Adaptive HIV-specific B cell-derived humoral immune defenses of the intestinal mucosa in children exposed to HIV via breast-feeding. [PDF]

PLoS ONE, 2013
BACKGROUND: We evaluated whether B cell-derived immune defenses of the gastro-intestinal tract are activated to produce HIV-specific antibodies in children continuously exposed to HIV via breast-feeding. METHODS: Couples of HIV-1-infected mothers (n = 14)
Sandrine Moussa, Mohammad-Ali Jenabian, Jean Chrysostome Gody, Josiane Léal, Gérard Grésenguet, Alain Le Faou, Laurent Bélec   +6 more
doaj   +1 more source

Rapid Point-of-Care Tests Using Staphylococcal Protein A Can Detect Early IgM Responses in HIV-1 and Treponema pallidum Infections

Microbiology Spectrum, 2022
Serological assays detecting IgM antibodies in addition to IgG antibodies have a diagnostic advantage in finding early infections. Staphylococcal protein A (SpA), widely used as an antibody-detecting reagent in various immunoassays, is considered to have
Valentina A. Schmidt, Victoria Rose Stevens, Javan Esfandiari, Konstantin P. Lyashchenko   +3 more
doaj   +1 more source

Post-Immune Antibodies in HIV-1 Infection in the Context of Vaccine Development: A Variety of Biological Functions and Catalytic Activities

Vaccines, 2022
Unlike many other viruses, HIV-1 is highly variable. The structure of the viral envelope changes as the infection progresses and is one of the biggest obstacles in developing an HIV-1 vaccine.
Anna Timofeeva, Sergey Sedykh, Georgy Nevinsky   +2 more
doaj   +1 more source

Bactericidal Immunity to Salmonella in Africans and Mechanisms Causing Its Failure in HIV Infection. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Nontyphoidal strains of Salmonella are a leading cause of death among HIV-infected Africans. Antibody-induced complement-mediated killing protects healthy Africans against Salmonella, but increased levels of anti-lipopolysaccharide (LPS ...
Yun Shan Goh, Francesca Necchi, Colette M O'Shaughnessy, Francesca Micoli, Massimiliano Gavini, Stephen P Young, Chisomo L Msefula, Esther N Gondwe, Wilson L Mandala, Melita A Gordon, Allan J Saul, Calman A MacLennan   +11 more
doaj   +1 more source

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Frontiers in Immunology, 2022
IntroductionInfants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions.MethodsIn this study, we evaluated Fc
Brittani M. Barrows, Brittani M. Barrows, Brittani M. Barrows, Shelly J. Krebs, Shelly J. Krebs, Ningbo Jian, Ningbo Jian, Michelle Zemil, Michelle Zemil, Bonnie M. Slike, Bonnie M. Slike, Vincent Dussupt, Vincent Dussupt, Ursula Tran, Ursula Tran, Letzibeth Mendez-Rivera, Letzibeth Mendez-Rivera, David Chang, David Chang, Anne Marie O’Sullivan, Anne Marie O’Sullivan, Brendan Mann, Brendan Mann, Eric Sanders-Buell, Eric Sanders-Buell, Zhanna Shubin, Zhanna Shubin, Matt Creegan, Matt Creegan, Dominic Paquin-Proulx, Dominic Paquin-Proulx, Philip Ehrenberg, Philip Ehrenberg, Agnes Laurence-Chenine, Agnes Laurence-Chenine, Kriengkrai Srithanaviboonchai, Rasmi Thomas, Michael A. Eller, Michael A. Eller, Guido Ferrari, Merlin Robb, Merlin Robb, Venigalla Rao, Sodsai Tovanabutra, Sodsai Tovanabutra, Victoria R. Polonis, Lindsay Wieczorek, Lindsay Wieczorek   +47 more
doaj   +1 more source

HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities. [PDF]

PLoS ONE, 2014
Many participants in microbicide trials remain uninfected despite ongoing exposure to HIV-1. Determining the emergence and nature of mucosal HIV-specific immune responses in such women is important, since these responses may contribute to protection and ...
Kelly E Seaton, Lamar Ballweber, Audrey Lan, Michele Donathan, Sean Hughes, Lucia Vojtech, M Anthony Moody, Hua-Xin Liao, Barton F Haynes, Christine G Galloway, Barbra A Richardson, Salim Abdool Karim, Charlene S Dezzutti, M Juliana McElrath, Georgia D Tomaras, Florian Hladik   +15 more
doaj   +1 more source

HIV-1/2 differentiation in a South African public laboratory

Southern African Journal of HIV Medicine, 2021
Background: The human immunodeficiency virus type-2 (HIV-2) prevalence in South Africa (SA) is unknown, however, sporadic cases have been reported.
Rendani T. Mafuyeka, Lynne M. Webber, Piet Becker, Simnikiwe H. Mayaphi   +3 more
doaj   +1 more source

Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies

Nature reviews. Immunology, 2022
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its ...
B. Haynes, K. Wiehe, P. Borrow, K. Saunders, Bette Korber, K. Wagh, A. McMichael, G. Kelsoe, B. Hahn, F. Alt, G. Shaw   +10 more
semanticscholar   +1 more source

Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition.

New England Journal of Medicine, 2021
BACKGROUND Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear. METHODS We enrolled at-risk cisgender men and transgender persons in the Americas and Europe in the ...
L. Corey, P. Gilbert, M. Juraska, D. Montefiori, L. Morris, S. Karuna, Srilatha Edupuganti, N. Mgodi, Allan C. deCamp, Erika Rudnicki, Yunda Huang, P. Gonzales, R. Cabello, C. Orrell, J. Lama, F. Laher, E. Lazarus, Jorge Sanchez, I. Frank, J. Hinojosa, M. Sobieszczyk, Kyle Marshall, P. Mukwekwerere, J. Makhema, L. Baden, J. Mullins, C. Williamson, J. Hural, M. McElrath, Carter Bentley, Simbarashe Takuva, Margarita M Gomez Lorenzo, D. Burns, Nicole Espy, A. Randhawa, Nidhi Kochar, E. Piwowar-Manning, D. Donnell, N. Sista, P. Andrew, J. Kublin, G. Gray, J. Ledgerwood, J. Mascola, M. Cohen   +44 more
semanticscholar   +1 more source

Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier

mBio, 2020
HIV-1 can cross the blood-brain barrier (BBB) to penetrate the brain and infect target cells, causing neurocognitive disorders as a result of neuroinflammation and brain damage.
Valérie Lorin, Anne Danckaert, Françoise Porrot, Olivier Schwartz, Philippe V. Afonso, Hugo Mouquet   +5 more
doaj   +1 more source