Results 31 to 40 of about 1,212,195 (296)

Potent functional antibody responses elicited by HIV-I DNA priming and boosting with heterologous HIV-1 recombinant MVA in healthy Tanzanian adults. [PDF]

PLoS ONE, 2015
UNLABELLED:Vaccine-induced HIV antibodies were evaluated in serum samples collected from healthy Tanzanian volunteers participating in a phase I/II placebo-controlled double blind trial using multi-clade, multigene HIV-DNA priming and recombinant ...
Agricola Joachim, Charlotta Nilsson, Said Aboud, Muhammad Bakari, Eligius F Lyamuya, Merlin L Robb, Mary A Marovich, Patricia Earl, Bernard Moss, Christina Ochsenbauer, Britta Wahren, Fred Mhalu, Eric Sandström, Gunnel Biberfeld, Guido Ferrari, Victoria R Polonis   +15 more
doaj   +1 more source

High Potential of Escalating HIV Transmission in a Low Prevalence Setting in Rural Tanzania. [PDF]

, 2007
Previous surveillance among antenatal clinic (ANC) attendees within the remote rural Manyara and Singida regions in Tanzania identified an imminent but still, relatively low HIV epidemic. We conducted a population-based HIV study to identify risk factors
Matee, Mecky I., Khadija I Yahya-Malima, Evjen-Olsen, Bjørg, Yahya-Malima, Khadija I., Yahya-Malima, Khadija I, Bjørg Evjen-Olsen, Knut Fylkesnes, Matee, Mecky I, Fylkesnes, Knut, Mecky I Matee   +9 more
core   +2 more sources

Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins

EBioMedicine, 2016
Human immunodeficiency virus type 1 (HIV-1) has evolved a sophisticated strategy to conceal conserved epitopes of its envelope glycoproteins (Env) recognized by antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies. These antibodies, which
Jonathan Richard, Beatriz Pacheco, Neelakshi Gohain, Maxime Veillette, Shilei Ding, Nirmin Alsahafi, William D. Tolbert, Jérémie Prévost, Jean-Philippe Chapleau, Mathieu Coutu, Manxue Jia, Nathalie Brassard, Jongwoo Park, Joel R. Courter, Bruno Melillo, Loïc Martin, Cécile Tremblay, Beatrice H. Hahn, Daniel E. Kaufmann, Xueling Wu, Amos B. Smith III, Joseph Sodroski, Marzena Pazgier, Andrés Finzi   +23 more
doaj   +1 more source

Quantifying Anti-HIV Envelope-Specific Antibodies in Plasma from HIV Infected Individuals

Viruses, 2019
Quantifying HIV Envelope (Env)-specific antibodies in HIV+ plasma is useful for interpreting antibody dependent cellular cytotoxicity assay results. HIV Env, the only viral protein expressed on the surface of infected cells, has a native trimeric closed ...
Sanket Kant, Ningyu Zhang, Jean-Pierre Routy, Cécile Tremblay, Réjean Thomas, Jason Szabo, Pierre Côté, Benoit Trottier, Roger LeBlanc, Danielle Rouleau, Marianne Harris, Franck P. Dupuy, Nicole F. Bernard   +12 more
doaj   +1 more source

Humoral immune responses to Pneumocystis jirovecii antigens in HIV-infected and uninfected young children with pneumocystis pneumonia.

PLoS ONE, 2013
BackgroundHumoral immune responses in human immunodeficiency virus (HIV)-infected and uninfected children with Pneumocystis pneumonia (PcP) are poorly understood.MethodsConsecutive children hospitalized with acute pneumonia, tachypnea, and hypoxia in ...
Kpandja Djawe, Kieran R Daly, Linda Levin, Heather J Zar, Peter D Walzer   +4 more
doaj   +1 more source

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]

, 2013
The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Ramos, Alejandra, Alexandre M. J. J. Bonvin (18079), David Lutje Hulsik, Verrips, C. Theo, Ying-ying Liu, Liu, Ying-ying, Battella, Simone, Jean-Pierre Simorre, C. Theo Verrips (200972), Miriam Hock, Miriam Hock (386536), Lucy Rutten (386540), Nika M. Strokappe (386532), Davis, David, Hinz, Andreas, Alejandra Ramos, Mohamed El Khattabi (386534), Bonvin, Alexandre M. J. J., Michael S Seaman, Rutten, Lucy, Alexandre M J J Bonvin, Simone Battella, Marlén M. I. Aasa-Chapman (208291), Pascal Poignard (244468), Sabin, Charles, Pascal Poignard, Seaman, Michael S., Anna Forsman Quigley, Pauline Macheboeuf, Seaman, Michael, Andreas Hinz (237046), Forsman Quigley, Anna, Anna Forsman Quigley (177474), Strokappe, Nika M, C Theo Verrips, Simorre, Jean-Pierre, Mohamed El Khattabi, Hulsik, David Lutje, Andreas Hinz, Winfried Weissenhorn (214542), McCoy, Laura E., Langedijk, Johannes P M, Johannes P. M. Langedijk (254439), Pauline Macheboeuf (386537), Charles Sabin, Marlén M I Aasa-Chapman, David Davis (190113), Robin A. Weiss (254468), Johannes P M Langedijk, Favier, Adrien, Lucy Rutten, Laura E. McCoy (386535), Adrien Favier (386539), Hock, Miriam, Alejandra Ramos (386538), Weiss, Robin A., Nika M Strokappe, David Lutje Hulsik (177480), Winfried Weissenhorn, Macheboeuf, Pauline, Lutje Hulsik, David, David Davis, Robin A Weiss, Aasa-Chapman, Marlén M. I., Strokappe, Nika M., Ying-ying Liu (386531), Weissenhorn, Winfried, Adrien Favier, Weiss, Robin A, Simone Battella (386533), Langedijk, Johannes P. M., Bonvin, Alexandre M J J, Michael S. Seaman (155998), Jean-Pierre Simorre (177519), El Khattabi, Mohamed, Seaman, Michael S, Aasa-Chapman, Marlén M I, Laura E McCoy, Poignard, Pascal, Verrips, C Theo, Charles Sabin (75940), Weissenhorn W, Poignard P, Hulsik, D.L., Biomolecular Imaging, el Khattabi, M., Hock M, McCoy, Laura E, McCoy LE, Simorre JP, Rutten L., Aasa-Chapman Marlén M. I., Hock Miriam, Davis David, Bonvin, A.M.J.J., Rutten Lucy, Macheboeuf P, Battella, S., Rutten, L., El Khattabi M, Battella Simone, Hinz A, Forsman Quigley A, Weiss Robin A., Langedijk JP, Lutje Hulsik D, Liu YY, Sub NMR Spectroscopy, Celbiologie, Aasa Chapman MM, Liu, Y.Y., Ramos Alejandra, Simorre Jean-Pierre, Verrips C. Theo, Ramos A, Liu Ying-ying, Sabin C, Favier A, Macheboeuf Pauline, Weiss RA, Verrips, C.T., Weissenhorn Winfried, Sub Biomolecular Imaging, Sub Cell Biology, Poignard Pascal, Davis D, Langedijk Johannes P. M., Hinz Andreas, Bonvin Alexandre M. J. J., Seaman Michael S., El Khattabi Mohamed, Bonvin AM, Dep Scheikunde, Strokappe NM, NMR Spectroscopy, Strokappe, N.M., Sabin Charles, Strokappe Nika M., Seaman MS, Lutje Hulsik David, McCoy Laura E., Verrips CT, Forsman Quigley Anna, Favier Adrien   +143 more
core   +3 more sources

Identification of CD4-Binding Site Dependent Plasma Neutralizing Antibodies in an HIV-1 Infected Indian Individual. [PDF]

PLoS ONE, 2015
Dissecting antibody specificities in the plasma of HIV-1 infected individuals that develop broadly neutralizing antibodies (bNAbs) is likely to provide useful information for refining target epitopes for vaccine design.
Lubina Khan, Muzamil Ashraf Makhdoomi, Sanjeev Kumar, Ambili Nair, Raiees Andrabi, Brenda E Clark, Kate Auyeung, Jayanta Bhattacharya, Madhu Vajpayee, Naveet Wig, Ralph Pantophlet, Kalpana Luthra   +11 more
doaj   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

Evaluation of the potency of the anti-idiotypic antibody Ab2/3H6 mimicking gp41 as an HIV-1 vaccine in a rabbit prime/boost study.

PLoS ONE, 2012
The HIV-1 envelope protein harbors several conserved epitopes that are recognized by broadly neutralizing antibodies. One of these neutralizing sites, the MPER region of gp41, is targeted by one of the most potent and broadly neutralizing monoclonal ...
Alexander Mader, Renate Kunert
doaj   +1 more source

Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses. [PDF]

PLoS ONE, 2011
Understanding the antibody response to HIV-1 in humans that show broad neutralizing serologic activity is a crucial step in trying to reproduce such responses by vaccination.
Hugo Mouquet, Florian Klein, Johannes F Scheid, Malte Warncke, John Pietzsch, Thiago Y K Oliveira, Klara Velinzon, Michael S Seaman, Michel C Nussenzweig   +8 more
doaj   +1 more source