Results 31 to 40 of about 320,592 (205)

Potent functional antibody responses elicited by HIV-I DNA priming and boosting with heterologous HIV-1 recombinant MVA in healthy Tanzanian adults. [PDF]

PLoS ONE, 2015
UNLABELLED:Vaccine-induced HIV antibodies were evaluated in serum samples collected from healthy Tanzanian volunteers participating in a phase I/II placebo-controlled double blind trial using multi-clade, multigene HIV-DNA priming and recombinant ...
Agricola Joachim, Charlotta Nilsson, Said Aboud, Muhammad Bakari, Eligius F Lyamuya, Merlin L Robb, Mary A Marovich, Patricia Earl, Bernard Moss, Christina Ochsenbauer, Britta Wahren, Fred Mhalu, Eric Sandström, Gunnel Biberfeld, Guido Ferrari, Victoria R Polonis   +15 more
doaj   +1 more source

Semen IgM, IgG1, and IgG3 Differentially Associate With Pro-Inflammatory Cytokines in HIV-Infected Men

Frontiers in Immunology, 2019
Genital inflammation significantly increases the risk for HIV infection. The seminal environment is enriched in pro-inflammatory cytokines and chemokines.
Thevani Pillay, Parveen Sobia, Abraham Jacobus Olivier, Kapil Narain, Lenine J. P. Liebenberg, Lenine J. P. Liebenberg, Sinaye Ngcapu, Sinaye Ngcapu, Mesuli Mhlongo, Jo-Ann S. Passmore, Jo-Ann S. Passmore, Jo-Ann S. Passmore, Jo-Ann S. Passmore, Cheryl Baxter, Derseree Archary, Derseree Archary   +15 more
doaj   +1 more source

A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody. [PDF]

, 2015
The CCR5 receptor plays a role in several key physiological and pathological processes and is an important therapeutic target. Inhibition of the CCR5 axis by passive or active immunisation offers one very selective strategy for intervention.
Akthar, S, Arnold, J, Brandt, M, Chain, B, Chayen, NE, Davis, D, Govada, L, Ji, C, Lapp, T, Noursadeghi, M, Sankuratri, S, Saridakis, E, Zhang, Y   +12 more
core   +8 more sources

Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins

EBioMedicine, 2016
Human immunodeficiency virus type 1 (HIV-1) has evolved a sophisticated strategy to conceal conserved epitopes of its envelope glycoproteins (Env) recognized by antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies. These antibodies, which
Jonathan Richard, Beatriz Pacheco, Neelakshi Gohain, Maxime Veillette, Shilei Ding, Nirmin Alsahafi, William D. Tolbert, Jérémie Prévost, Jean-Philippe Chapleau, Mathieu Coutu, Manxue Jia, Nathalie Brassard, Jongwoo Park, Joel R. Courter, Bruno Melillo, Loïc Martin, Cécile Tremblay, Beatrice H. Hahn, Daniel E. Kaufmann, Xueling Wu, Amos B. Smith III, Joseph Sodroski, Marzena Pazgier, Andrés Finzi   +23 more
doaj   +1 more source

Identification of CD4-Binding Site Dependent Plasma Neutralizing Antibodies in an HIV-1 Infected Indian Individual. [PDF]

PLoS ONE, 2015
Dissecting antibody specificities in the plasma of HIV-1 infected individuals that develop broadly neutralizing antibodies (bNAbs) is likely to provide useful information for refining target epitopes for vaccine design.
Lubina Khan, Muzamil Ashraf Makhdoomi, Sanjeev Kumar, Ambili Nair, Raiees Andrabi, Brenda E Clark, Kate Auyeung, Jayanta Bhattacharya, Madhu Vajpayee, Naveet Wig, Ralph Pantophlet, Kalpana Luthra   +11 more
doaj   +1 more source

Quantifying Anti-HIV Envelope-Specific Antibodies in Plasma from HIV Infected Individuals

Viruses, 2019
Quantifying HIV Envelope (Env)-specific antibodies in HIV+ plasma is useful for interpreting antibody dependent cellular cytotoxicity assay results. HIV Env, the only viral protein expressed on the surface of infected cells, has a native trimeric closed ...
Sanket Kant, Ningyu Zhang, Jean-Pierre Routy, Cécile Tremblay, Réjean Thomas, Jason Szabo, Pierre Côté, Benoit Trottier, Roger LeBlanc, Danielle Rouleau, Marianne Harris, Franck P. Dupuy, Nicole F. Bernard   +12 more
doaj   +1 more source

Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses

iScience, 2023
Summary: Mycobacterium tuberculosis (Mtb) is the most common infection among people with HIV (PWH). Mtb disease-associated inflammation could affect HIV-directed immune responses in PWH.
Bukola Adeoye, Lydia Nakiyingi, Yvetane Moreau, Ethel Nankya, Alex J. Olson, Mo Zhang, Karen R. Jacobson, Amita Gupta, Yukari C. Manabe, Mina C. Hosseinipour, Johnstone Kumwenda, Manish Sagar   +11 more
doaj   +1 more source

Humoral immune responses to Pneumocystis jirovecii antigens in HIV-infected and uninfected young children with pneumocystis pneumonia.

PLoS ONE, 2013
BackgroundHumoral immune responses in human immunodeficiency virus (HIV)-infected and uninfected children with Pneumocystis pneumonia (PcP) are poorly understood.MethodsConsecutive children hospitalized with acute pneumonia, tachypnea, and hypoxia in ...
Kpandja Djawe, Kieran R Daly, Linda Levin, Heather J Zar, Peter D Walzer   +4 more
doaj   +1 more source

Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals [PDF]

, 2014
Background The MPER region of the HIV-1 envelope glycoprotein gp41 is targeted by broadly neutralizing antibodies. However, the localization of this epitope in a hydrophobic environment seems to hamper the elicitation of these antibodies in HIV infected
Blanco, Julià, Carrillo, Jorge, Clotet, Bonaventura, Curriu, Marta, García, Elisabet, Marfil, Sílvia, Molinos-Albert, Luis M., Rodríguez de la Concepción, Maria L.   +7 more
core   +2 more sources

Sub-inhibitory concentrations of human α-defensin potentiate neutralizing antibodies against HIV-1 gp41 pre-hairpin intermediates in the presence of serum. [PDF]

PLoS Pathogens, 2013
Human defensins are at the forefront of the host responses to HIV and other pathogens in mucosal tissues. However, their ability to inactivate HIV in the bloodstream has been questioned due to the antagonistic effect of serum.
Lusine Demirkhanyan, Mariana Marin, Wuyuan Lu, Gregory B Melikyan   +3 more
doaj   +1 more source