Results 181 to 190 of about 4,391,067 (296)

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

Post-market surveillance of antiretroviral drug quality in Tanzania in the context of rising HIV drug resistance. [PDF]

Sci Rep
Mlugu EM, Mhagama JB, Sangeda RZ, Kunambi PP, Samwel T, Shiletiwa N, Gotora G, Chambiri SM, Matiko D, Hipolite D, Mwalwisi YH, Fimbo AM.   +11 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Utilizing HIV Proviral DNA to Assess for the Presence of HIV Drug Resistance. [PDF]

Clin Infect Dis
Wensing AM, Charpentier C, Calvez V, Ceccherini-Silberstein F, Günthard HF, Jacobsen DM, Paredes R, Shafer RW, Richman DD.   +8 more
europepmc   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Notable transmitted HIV drug resistance among people who inject drugs in Pakistan. [PDF]

J Antimicrob Chemother
Melnychuk S, Thompson LH, Archibald C, Blanchard JF, Emmanuel F, Reza T, Dar N, Sandstrom P, Shaw SY, Becker ML, Cholette F.   +10 more
europepmc   +1 more source

New drug for multidrug-resistant HIV [PDF]

Nature Biotechnology, 2018
openaire   +2 more sources

Investigating Tuberculosis Dynamics Under Various Control Strategies: A Comprehensive Analysis Using Real Statistical Data

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In the present investigation, a mathematical model with vaccination, treatment, and environmental impact under real data is presented. Initially, we present the model without any interventions, followed by an examination of its equilibrium points.
Bashir Al‐Hdaibat, Mahmoud H. DarAssi, Irfan Ahmad, Muhammad Altaf Khan, Reem Algethamie   +4 more
wiley   +1 more source

Nationwide patterns of HIV drug resistance and high viral load in Sub-Saharan African countries. [PDF]

J Antimicrob Chemother
Elbur AI, Gandla S, Nakka R, Khan R, Ghebremichael M.   +4 more
europepmc   +1 more source

Frequent Versus Single Active Bouts Differentially Affect Movement Behavior and Energy Balance in Adults With Overweight/Obesity

Obesity, EarlyView.
ABSTRACT Objective This study aimed to investigate the effects of breaking up sedentary behavior (SB) on daily movement behavior and energy balance in adults with overweight/obesity. Methods Thirty participants (16F/14M; 34.2 ± 7.3 years; 29.5 ± 3.2 kg/m2) were randomized to either BREAK (multiple 5‐min brisk walking bouts) or a duration‐matched ...
Heloisa C. Santo Andre, Elisa Le Roux, Nathan P. De Jong, Patricia R. Smith, Andrew H. Lange, Carlos Mendez, Alexandre Zahariev, Melissa L. Mamele, Ginger Johnson, Zhaoxing Pan, Chantal Simon, Daniel H. Bessesen, Ana J. Pinto, Audrey Bergouignan   +13 more
wiley   +1 more source