Results 121 to 130 of about 36,030 (253)

Structural Insights From HIV-Antibody Co-Evolution And Related Immunization Studies [PDF]

, 2018
Human immunodeficiency virus type 1 (HIV-1) is a rapidly evolving pathogen and causes the acquired immunodeficiency syndrome (AIDS) in humans. There are ~30-35 million people infected with HIV around the world, and ~25 million have died since the first ...
Fera, Daniela, Morriss, Julia W., , \u2719, Nguyen, Diep, , \u2719, Ton, Therese, , \u2719, Zhou, Jeffrey O., , \u2719   +4 more
core   +1 more source

Anti-HIV therapy: pipeline approaches and future directions [PDF]

, 2011
Human immunodeficiency virus (HIV), with about 30 million deaths and double infections (in developing countries), is an open challenge today for global scientists.
Lavkush Dwivedi, Mansi Shrivastava
core   +2 more sources

Conversion of an immunogenic human immunodeficiency virus (HIV) envelope synthetic peptide to a tolerogen in chimpanzees by the fusogenic domain of HIV gp41 envelope protein

Journal of Experimental Medicine, 1993
The fusogenic (F) domain of human immunodeficiency virus (HIV) gp41 envelope (env) protein has sequence similarities to many virus and mediates the fusion of HIV-infected cells. During a survey of the immunogenicity of HIV env peptides in chimpanzees, we
B. Haynes, Larry O. Arthur, Patrice Frost, Thomas J. Matthews, A. J. Langlois, T. Palker, Mary Kate Hart, R. Scearce, Dawn M. Jones, C. McDanal, Janet S. Ottinger, D. P. Bolognesi, Kent J. Weinhold   +12 more
semanticscholar   +1 more source

Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity

Frontiers in Immunology
IntroductionHIV-1 envelope (Env) is the key target for antibodies (Abs) against the virus and thus an important HIV-1 vaccine component. Env is synthesized from a gp160 precursor with a signal peptide (SP) at its N-terminus.
Chitra Upadhyay, Priyanka Rao, Mohammad Amin Behzadi, Roya Feyznezhad, Gregory S. Lambert, Rajnish Kumar, Madhu Kumar, Weiming Yang, Xunqing Jiang, Christina C. Luo, Arthur Nadas, James Arthos, Xiang-Peng Kong, Hui Zhang, Catarina E. Hioe, Catarina E. Hioe, J. Andrew Duty   +16 more
doaj   +1 more source

A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques

Journal of Virology, 2017
Trimeric HIV-1 envelope (Env) immunogens are attractive due to their ability to display quaternary epitopes targeted by broadly neutralizing antibodies (bNAbs) while obscuring unfavorable epitopes.
Andrew T. Jones, V. Chamcha, S. Kesavardhana, Xiaoying Shen, David Beaumont, R. Das, L. Wyatt, C. Labranche, S. Stanfield-Oakley, G. Ferrari, D. Montefiori, B. Moss, G. Tomaras, R. Varadarajan, R. Amara   +14 more
semanticscholar   +1 more source

Wingless-type Mammary Tumor Virus Integration Site Family, Member 5A (Wnt5a) Regulates Human Immunodeficiency Virus Type 1 (HIV-1) Envelope Glycoprotein 120 (gp120)-induced Expression of Pro-Inflammatory Cytokines via the Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and c-Jun N-terminal Kina

Journal of Biological Chemistry, 2013
Background: HIV-1 infection causes chronic neuroinflammation in the central nervous system (CNS). Results: The spinal cytokine up-regulation induced by HIV-1 gp120 protein depends on Wnt5a/CaMKII and/or Wnt5a/JNK pathways.
Bei Li, Yuqiang Shi, J. Shu, Junling Gao, Ping Wu, Shao-Jun Tang   +5 more
semanticscholar   +1 more source

Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120

Virology, 2012
Feglymycin (FGM), a natural Streptomyces-derived 13mer peptide, consistently inhibits HIV replication in the lower μM range. FGM also inhibits HIV cell-to-cell transfer between HIV-infected T cells and uninfected CD4(+) T cells and the DC-SIGN-mediated viral transfer to CD4(+) T cells.
Férir, Geoffrey, Hänchen, Anne, François, Katrien O., Hoorelbeke, Bart, Huskens, Dana, Dettner, Frank, Süssmuth, Roderich D., Schols, Dominique   +7 more
openaire   +2 more sources

Protein–Protein Interaction between Surfactant Protein D and DC-SIGN via C-Type Lectin Domain Can Suppress HIV-1 Transfer

Frontiers in Immunology, 2017
Surfactant protein D (SP-D) is a soluble C-type lectin, belonging to the collectin (collagen-containing calcium-dependent lectin) family, which acts as an innate immune pattern recognition molecule in the lungs at other mucosal surfaces.
Eswari Dodagatta-Marri, Daniel A. Mitchell, Hrishikesh Pandit, Archana Sonawani, Valarmathy Murugaiah, Susan Idicula-Thomas, Béatrice Nal, Béatrice Nal, Maha M. Al-Mozaini, Anuvinder Kaur, Taruna Madan, Uday Kishore   +11 more
doaj   +1 more source

HbAHP-25, an In-Silico Designed Peptide, Inhibits HIV-1 Entry by Blocking gp120 Binding to CD4 Receptor.

PLoS ONE, 2015
Human Immunodeficiency Virus (HIV-1) poses a serious threat to the developing world and sexual transmission continues to be the major source of new infections.
Tahir Bashir, Mandar Patgaonkar, Selvaa C Kumar, Achhelal Pasi, Kudumula Venkata Rami Reddy   +4 more
doaj   +1 more source

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. [PDF]

, 2019
Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal models, suggesting that a vaccine that elicits these antibodies would be protective in humans.
Abernathy, Morgan E, Barnes, Christopher O, Bauer, Jens, Bjorkman, Pamela J, Cohen, Alexander A, Escolano, Amelia, Gao, Han, Gautam, Rajeev, Gazumyan, Anna, Golijanin, Jovana, Gristick, Harry B, Irvine, Darrell J, Keeffe, Jennifer R, Martin, Malcolm A, McGuire, Andrew T, Merkenschlager, Julia, Montefiori, David C, Nogueira, Lilian, Nussenzweig, Michel C, Oliveira, Thiago Y, Pai, Joy, Seaman, Michael S, Silva, Murillo, Stamatatos, Leonidas, Voll, Alisa V, Wang, Haoqing, Wang, Zijun, Wells, Lance, West, Anthony P, Yao, Kai-Hui, Yost, Daniel, Zhao, Peng   +31 more
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