Results 131 to 140 of about 15,684 (181)

Surface Plasmon Resonance as a Tool in Antiviral Drug Discovery Research. [PDF]

Biosensors (Basel)
Wegrzyn KE, Matsoukas JM.
europepmc   +1 more source

Targeting of specific CCR5-G protein complexes underlies biased signaling by HIV-1 envelope glycoproteins. [PDF]

Cell Commun Signal
Gasser R, Colin P, Jacquemard C, Montagné T, Zhou Z, Pons V, Kostenis E, Galés C, Kellenberger E, Lagane B.   +9 more
europepmc   +1 more source

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120 [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Significant heterogeneity exists in the structure and antigenicity of HIV-1 envelope protein (Env) gp120 due, in part, to various posttranslational modifications. Using glycan and antigenic analysis, we show that the signal peptide (SP) of HIV Env can impact the glycan profile of gp120, which in turn impacts antigenicity of the ...
Jason Yolitz, Donald Van Ryk, Fatima Nawaz   +2 more
exaly   +3 more sources

HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell [PDF]

Cancers, 2018
Patients infected with human immunodeficiency virus (HIV) are more prone to developing cancers, including glioblastomas (GBMs). The median survival for HIV positive GBM patients is significantly shorter than for those who are uninfected, despite the fact that they receive the same treatments.
Yuriy V Kucheryavykh, Nataliya Chorna, Mikhail Inyushin   +2 more
exaly   +3 more sources

Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist [PDF]

Brain Research, 1992
The external envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV) has been shown to be toxic to neurons in culture. To further investigate the neurological effects of gp120, the involvement of this protein with the acquisition of spatial discrimination was assessed.
John R Glowa, Douglas E Brenneman, Illana Gozes   +2 more
exaly   +4 more sources

An HIV Envelope gp120-Fc Fusion Protein Elicits Effector Antibody Responses in Rhesus Macaques

Vaccine Journal, 2017
ABSTRACT A goal for HIV prevention programs is to develop safe, effective vaccines that elicit durable and broadly protective antibodies. Many vaccine programs focus on the immune responses to critical epitopes in the gp120 portion of HIV envelope glycoprotein (Env) and seek to improve the quality and quantity of antibodies by ...
Zhanna Shubin, Bhawna Poonia, Guido Ferrari   +2 more
exaly   +3 more sources

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Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons

NeuroReport, 1996
A new in vitro system comprising a pure population of neurons, human NT cells, was used to characterize the direct neurotoxic effect of HIV-1 envelope protein gp120. Cytotoxicity was monitored by a quantitative assay after exposure to recombinant gp120 in the presence or absence of other reagents.
P, Wu, P, Price, B, Du, W C, Hatch, E F, Terwilliger   +4 more
openaire   +2 more sources

HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro

Journal of Leukocyte Biology, 1994
Abstract We investigated the effect of human immunodeficiency virus type 1 (HIV-1) recombinant gp120 (rec.gp120) on phenotype and function of cultured monocytes. Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti-CD3, the Fc receptor–mediated chemiluminescence of monocytes ...
I, Dürrbaum-Landmann, E, Kaltenhäuser, H D, Flad, M, Ernst   +3 more
openaire   +2 more sources

The HIV-1 envelope protein GP120 induces neuronal apoptosis in hippocampal slices

NeuroReport, 1996
The HIV-1 envelope protein gp120 produces neuronal cell damage in primary cultures of a variety of cell types including hippocampal and retinal ganglion cell neurons. The properties of primary cell cultures are, however, often markedly different from those of cells living in their normal environment.
D, Aggoun-Zouaoui, C, Charriaut-Marlangue, S, Rivera, I, Jorquera, Y, Ben-Ari, A, Represa   +5 more
openaire   +2 more sources

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

The Journal of Immunology, 1988
Abstract The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing ...
D C, Diamond, B P, Sleckman, T, Gregory, L A, Lasky, J L, Greenstein, S J, Burakoff   +5 more
openaire   +2 more sources