Results 151 to 160 of about 15,684 (181)
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Journal of Biomolecular Structure and Dynamics, 1999
The model of spatial structure for the principal neutralizing determinant (PND) of the HIV-1 envelope protein gp120 is proposed in terms of two-dimensional nuclear Overhauser effect (NOE) spectroscopy data. To build the model, the NMR-based theoretical conformational analysis of synthetic PND peptides of length 40, 24, and 12 residues is carried out ...
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The model of spatial structure for the principal neutralizing determinant (PND) of the HIV-1 envelope protein gp120 is proposed in terms of two-dimensional nuclear Overhauser effect (NOE) spectroscopy data. To build the model, the NMR-based theoretical conformational analysis of synthetic PND peptides of length 40, 24, and 12 residues is carried out ...
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Journal of Neuroimmunology, 2001
Painful sensory neuropathy is a common and debilitating consequence of human immunodeficiency virus (HIV). The underlying causes of neuropathic pain are most likely not due to direct infection of the nervous system by active virus. The goal of this study was to determine whether epineural exposure to the HIV-1 envelope protein gp120 could lead to ...
U, Herzberg, J, Sagen
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Painful sensory neuropathy is a common and debilitating consequence of human immunodeficiency virus (HIV). The underlying causes of neuropathic pain are most likely not due to direct infection of the nervous system by active virus. The goal of this study was to determine whether epineural exposure to the HIV-1 envelope protein gp120 could lead to ...
U, Herzberg, J, Sagen
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Molecular Immunology, 1994
Jacalin is a multimeric plant lectin able to interact with the lymphocyte cell-surface molecule CD4, a known receptor for the human immunodeficiency virus type 1 (HIV-1). Moreover, jacalin is able to block HIV-1 infection of CD4+ lymphoblastoid cells. Here we studied whether jacalin prevents HIV-1 gp120-CD4 interactions.
P, Corbeau, M, Haran, H, Binz, C, Devaux
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Jacalin is a multimeric plant lectin able to interact with the lymphocyte cell-surface molecule CD4, a known receptor for the human immunodeficiency virus type 1 (HIV-1). Moreover, jacalin is able to block HIV-1 infection of CD4+ lymphoblastoid cells. Here we studied whether jacalin prevents HIV-1 gp120-CD4 interactions.
P, Corbeau, M, Haran, H, Binz, C, Devaux
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European Journal of Biochemistry, 2001
Based on experimental NMR data, a model was generated for the conformation of the disulfide‐bond‐closed cyclic peptide corresponding to the whole V3 loop of the consensus HIV‐1 strain in a 20% trifluoroethanol/water solution. The obtained family of structures shows a prominent and well‐defined amphipathic α helix at the C‐terminal end of the peptide ...
Vranken, W F +3 more
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Based on experimental NMR data, a model was generated for the conformation of the disulfide‐bond‐closed cyclic peptide corresponding to the whole V3 loop of the consensus HIV‐1 strain in a 20% trifluoroethanol/water solution. The obtained family of structures shows a prominent and well‐defined amphipathic α helix at the C‐terminal end of the peptide ...
Vranken, W F +3 more
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HIV-1 envelope protein gp120. Glycovirology of the V3 loop
2008The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5 ...
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The HIV Envelope Protein gp120 in the Nervous System
Biochemical Pharmacology, 1998M.Tiziana Corasaniti +3 more
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European Journal of Neuroscience, 1992
AbstractPrior studies with in vitro model systems have suggested that at least part of the neurological manifestations of AIDS may stem from neuronal injury involving the HIV‐1 coat protein gp120. This form of neuronal damage is most probably mediated indirectly by a complex set of cellular interactions among macrophages, astrocytes, and neurons ...
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AbstractPrior studies with in vitro model systems have suggested that at least part of the neurological manifestations of AIDS may stem from neuronal injury involving the HIV‐1 coat protein gp120. This form of neuronal damage is most probably mediated indirectly by a complex set of cellular interactions among macrophages, astrocytes, and neurons ...
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V3 loop region of the HIV-1 gp120 envelope protein is essential for virus infectivity.
Virology, 1992The mechanism by which HIV-1 mediates cell fusion and penetrates target cells, subsequent to receptor (CD4) binding, is not well understood. However, neutralizing antibodies, which recognize the principal neutralizing determinants of the gp120 envelope protein (the V3 loop region, residues 296 to 331), have been shown to effectively block cell fusion ...
L A, Ivanoff +8 more
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HIV-1 envelope protein gp120 impairs intracellular antifungal mechanisms in human monocytes.
1998The key to success of fungal opportunistic pathogens in the immunocompromised host is related to survival inside phagocytic cells, which represent the first line of defense against microorganisms. The contribution of human immunodeficiency virus-1 recombinant envelope protein gp120 on effector functions of peripheral blood monocytes (PBM) against ...
PIETRELLA, Donatella +5 more
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