Results 171 to 180 of about 5,218,351 (211)

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

The Journal of Immunology, 1988
Abstract The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing ...
D C, Diamond, B P, Sleckman, T, Gregory, L A, Lasky, J L, Greenstein, S J, Burakoff   +5 more
openaire   +2 more sources

An HIV Envelope gp120-Fc Fusion Protein Elicits Effector Antibody Responses in Rhesus Macaques.

Vaccine Journal, 2017
ABSTRACT A goal for HIV prevention programs is to develop safe, effective vaccines that elicit durable and broadly protective antibodies. Many vaccine programs focus on the immune responses to critical epitopes in the gp120 portion of HIV envelope glycoprotein (Env) and seek to improve the quality and quantity of antibodies by ...
Guido Ferrari, Bhawna Poonia, C David Pauza   +2 more
exaly   +3 more sources

Assembly, Structure, and Antigenic Properties of Virus-Like Particles Rich in HIV-1 Envelope gp120

Virology, 2004
In order to improve the immunogenicity of HIV-1 envelope glycoproteins, we have fused gp120 to a carrier protein, hepatitis B surface antigen (HBsAg), which is capable of spontaneous assembly into virus-like particles.
Raymond, Megan, Aberdeen, Anne, Spadaccini, Angelo, Berkower, Ira, Muller, Jacqueline   +4 more
exaly   +2 more sources

Interaction of several complement proteins with gp120 and gp41, the two envelope gycoproteins of HIV-1

AIDS, 1995
To study the binding of human complement proteins to gp41 and gp120 of HIV-1.The interaction of complement proteins with gp41 and gp120 and their effect on the gp41-gp120 complex in enzyme-linked immunosorbent assays (ELISA) and on stably transfected Schneider-2 cells expressing a gp41-gp120 complex was investigated.
H, Stoiber, C, Ebenbichler, R, Schneider, J, Janatova, M P, Dierich   +4 more
openaire   +2 more sources

The HIV-1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion

The Journal of Immunology, 1991
Abstract Results and conclusions concerning the ability of HIV glycoprotein (gp) 120 to stimulate monokine secretion have been equivocal, based on observations using natural gp120 derived from infected human cells and a Chinese hamster ovary (CHO) cell-derived recombinant fusion protein. Current studies were designed to determine whether
K A, Clouse, L M, Cosentino, K A, Weih, S W, Pyle, P B, Robbins, H D, Hochstein, V, Natarajan, W L, Farrar   +7 more
openaire   +2 more sources

HIV-1 gp120 envelope protein modulates proliferation of human glomerular epithelial cells

Journal of Cellular Biochemistry, 2000
Glomerular epithelial cells (GEC) have been demonstrated to undergo morphological alterations in human immunodeficiency virus (HIV)-associated focal glomerulosclerosis. In the present study, we evaluated the effect of HIV-1 gp120 envelope protein on the growth of cultured human (H) GEC.
P C, Singhal, K, Reddy, N, Franki, G, Ding   +3 more
openaire   +2 more sources

Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120

NeuroReport, 1992
HIV-1-related neuronal injury may involve a complex web of viral proteins and cytokines, but neurons themselves are not infected. The HIV envelope protein gp120 has been shown to engender an early increase in neuronal free calcium followed by delayed excitotoxic-like damage, which is prevented by N-methyl-D-aspartate (NMDA) antagonists.
openaire   +2 more sources

Potent and Broadly Neutralizing Antibodies Targeting HIV Envelope Protein gp120

Future Virology, 2012
Evaluation of: Pejchal R, Doores KJ, Walker LM et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science 334(6059), 1097–1103 (2011). A dense glycan shield of HIV Env protein gp120 protects gp120 from antibody recognition.
openaire   +1 more source

Antibody-dependent cellular cytotoxicity is directed against both the gp120 and gp41 envelope proteins of HIV

Aids, 1989
To define the target antigens for antibody-dependent cellular cytotoxicity (ADCC), assays were performed using affinity-purified human immunoglobulin (Ig) or polyclonal rabbit sera directed against specific proteins of HIV. ADCC was not found using affinity-purified anti-core (p25) human Ig or sera obtained from rabbits hyper-immunized with recombinant
L A, Evans, G, Thomson-Honnebier, K, Steimer, E, Paoletti, M E, Perkus, H, Hollander, J A, Levy   +6 more
openaire   +2 more sources

Use of Human CD4 Transgenic Mice for Studying Immunogenicity of HIV-1 Envelope Protein gp120

Transgenic Research, 2001
HIV-1 envelope protein, gp120, is a major immunogenic protein of the AIDS virus. A specific feature of this protein is its interaction with the receptor protein, human CD4, an important component of the immune system. This interaction might affect the immunogenic properties of the gp 120 and modulate the immune response towards HIV.
J, Seagal, E, Spectorman, J M, Gershoni, G F, Denisova   +3 more
openaire   +2 more sources