Results 171 to 180 of about 25,017 (220)

Exceptionally broad HIV-1 neutralization via bispecific antibody-mediated prepositioning. [PDF]

open access: yesProc Natl Acad Sci U S A
Kim S   +6 more
europepmc   +1 more source
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HIV-1 gp120 envelope protein modulates proliferation of human glomerular epithelial cells

Journal of Cellular Biochemistry, 2000
Glomerular epithelial cells (GEC) have been demonstrated to undergo morphological alterations in human immunodeficiency virus (HIV)-associated focal glomerulosclerosis. In the present study, we evaluated the effect of HIV-1 gp120 envelope protein on the growth of cultured human (H) GEC.
P C, Singhal   +3 more
openaire   +2 more sources

The HIV-1 envelope protein GP120 induces neuronal apoptosis in hippocampal slices

NeuroReport, 1996
The HIV-1 envelope protein gp120 produces neuronal cell damage in primary cultures of a variety of cell types including hippocampal and retinal ganglion cell neurons. The properties of primary cell cultures are, however, often markedly different from those of cells living in their normal environment.
D, Aggoun-Zouaoui   +5 more
openaire   +2 more sources

Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons

NeuroReport, 1996
A new in vitro system comprising a pure population of neurons, human NT cells, was used to characterize the direct neurotoxic effect of HIV-1 envelope protein gp120. Cytotoxicity was monitored by a quantitative assay after exposure to recombinant gp120 in the presence or absence of other reagents.
P, Wu   +4 more
openaire   +2 more sources

HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro

Journal of Leukocyte Biology, 1994
Abstract We investigated the effect of human immunodeficiency virus type 1 (HIV-1) recombinant gp120 (rec.gp120) on phenotype and function of cultured monocytes. Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti-CD3, the Fc receptor–mediated chemiluminescence of monocytes ...
I, Dürrbaum-Landmann   +3 more
openaire   +2 more sources

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

The Journal of Immunology, 1988
Abstract The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing ...
D C, Diamond   +5 more
openaire   +2 more sources

The HIV-1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion

The Journal of Immunology, 1991
Abstract Results and conclusions concerning the ability of HIV glycoprotein (gp) 120 to stimulate monokine secretion have been equivocal, based on observations using natural gp120 derived from infected human cells and a Chinese hamster ovary (CHO) cell-derived recombinant fusion protein. Current studies were designed to determine whether
K A, Clouse   +7 more
openaire   +2 more sources

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