Results 181 to 190 of about 5,218,351 (211)
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Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1996
A novel class of polyanionic proteins with potent anti-human immunodeficiency virus type 1 activity, the negatively charged albumins (NCAs), have been reported previously. In vitro antiviral assays established that these compounds preferentially inhibit virus-cell fusion and syncytium formation and that virus-cell binding is less affected.
Kuipers, M. E. +7 more
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A novel class of polyanionic proteins with potent anti-human immunodeficiency virus type 1 activity, the negatively charged albumins (NCAs), have been reported previously. In vitro antiviral assays established that these compounds preferentially inhibit virus-cell fusion and syncytium formation and that virus-cell binding is less affected.
Kuipers, M. E. +7 more
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Spatial Structure Model of the CD4 Receptor-Binding Site of the HIV Envelope Protein gp120
Journal of Biomolecular Structure and Dynamics, 1998In this study we have undertaken attempt to predict 3D structure of the CD4 receptor-binding site of the HIV envelope protein gp120. The structure of this site has been constructed by the analysis of low-energy conformers of peptide T, an HIV reproduction inhibitor with amino acid sequence corresponding to the fragment Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr ...
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Blood, 2004
Abstract Lymphoid organs are the major anatomical home of HIV, where the virus replicates during both the acute and chronic phases of infections. In this regard, there are significantly more infected cells in lymph nodes (LNs) than in circulating blood, and these infected cells are a major reservoir of infectious HIV.
Xuefeng Zhang +2 more
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Abstract Lymphoid organs are the major anatomical home of HIV, where the virus replicates during both the acute and chronic phases of infections. In this regard, there are significantly more infected cells in lymph nodes (LNs) than in circulating blood, and these infected cells are a major reservoir of infectious HIV.
Xuefeng Zhang +2 more
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Journal of Biomolecular Structure and Dynamics, 1999
The model of spatial structure for the principal neutralizing determinant (PND) of the HIV-1 envelope protein gp120 is proposed in terms of two-dimensional nuclear Overhauser effect (NOE) spectroscopy data. To build the model, the NMR-based theoretical conformational analysis of synthetic PND peptides of length 40, 24, and 12 residues is carried out ...
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The model of spatial structure for the principal neutralizing determinant (PND) of the HIV-1 envelope protein gp120 is proposed in terms of two-dimensional nuclear Overhauser effect (NOE) spectroscopy data. To build the model, the NMR-based theoretical conformational analysis of synthetic PND peptides of length 40, 24, and 12 residues is carried out ...
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Molecular Immunology, 1994
Jacalin is a multimeric plant lectin able to interact with the lymphocyte cell-surface molecule CD4, a known receptor for the human immunodeficiency virus type 1 (HIV-1). Moreover, jacalin is able to block HIV-1 infection of CD4+ lymphoblastoid cells. Here we studied whether jacalin prevents HIV-1 gp120-CD4 interactions.
P, Corbeau, M, Haran, H, Binz, C, Devaux
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Jacalin is a multimeric plant lectin able to interact with the lymphocyte cell-surface molecule CD4, a known receptor for the human immunodeficiency virus type 1 (HIV-1). Moreover, jacalin is able to block HIV-1 infection of CD4+ lymphoblastoid cells. Here we studied whether jacalin prevents HIV-1 gp120-CD4 interactions.
P, Corbeau, M, Haran, H, Binz, C, Devaux
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European Journal of Biochemistry, 2001
Based on experimental NMR data, a model was generated for the conformation of the disulfide‐bond‐closed cyclic peptide corresponding to the whole V3 loop of the consensus HIV‐1 strain in a 20% trifluoroethanol/water solution. The obtained family of structures shows a prominent and well‐defined amphipathic α helix at the C‐terminal end of the peptide ...
Vranken, W F +3 more
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Based on experimental NMR data, a model was generated for the conformation of the disulfide‐bond‐closed cyclic peptide corresponding to the whole V3 loop of the consensus HIV‐1 strain in a 20% trifluoroethanol/water solution. The obtained family of structures shows a prominent and well‐defined amphipathic α helix at the C‐terminal end of the peptide ...
Vranken, W F +3 more
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The HIV Envelope Protein gp120 in the Nervous System
Biochemical Pharmacology, 1998M.Tiziana Corasaniti +3 more
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European Journal of Neuroscience, 1992
AbstractPrior studies with in vitro model systems have suggested that at least part of the neurological manifestations of AIDS may stem from neuronal injury involving the HIV‐1 coat protein gp120. This form of neuronal damage is most probably mediated indirectly by a complex set of cellular interactions among macrophages, astrocytes, and neurons ...
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AbstractPrior studies with in vitro model systems have suggested that at least part of the neurological manifestations of AIDS may stem from neuronal injury involving the HIV‐1 coat protein gp120. This form of neuronal damage is most probably mediated indirectly by a complex set of cellular interactions among macrophages, astrocytes, and neurons ...
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V3 loop region of the HIV-1 gp120 envelope protein is essential for virus infectivity.
Virology, 1992The mechanism by which HIV-1 mediates cell fusion and penetrates target cells, subsequent to receptor (CD4) binding, is not well understood. However, neutralizing antibodies, which recognize the principal neutralizing determinants of the gp120 envelope protein (the V3 loop region, residues 296 to 331), have been shown to effectively block cell fusion ...
L A, Ivanoff +8 more
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HIV-1 envelope protein gp120 impairs intracellular antifungal mechanisms in human monocytes.
1998The key to success of fungal opportunistic pathogens in the immunocompromised host is related to survival inside phagocytic cells, which represent the first line of defense against microorganisms. The contribution of human immunodeficiency virus-1 recombinant envelope protein gp120 on effector functions of peripheral blood monocytes (PBM) against ...
PIETRELLA, Donatella +5 more
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