Results 121 to 130 of about 45,597 (259)
HIV Medicine, Volume 27, Issue 1, Page 86-95, January 2026.Abstract Objectives Alterations in lipids and apolipoproteins contribute to cardiovascular disease (CVD) and are common in people with HIV. The aim of our study was to compare lipid profiles and body composition between people with and without HIV and to explore whether any associations with HIV could be explained by socio‐demographic, clinical ...
S. Savinelli +11 more
wiley +1 more source
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase [PDF]
, 2019 Ping Gao +10 more
openalex +1 more source
Antiviral Chemistry and Chemotherapy, 2006 The mechanism of integrase is generally accepted to be dependant on the presence of two divalent metal ions in the active site. However, the only available crystal structures of HIV-1 integrase contain either one or no metal ions, hampering structure-based design studies of integrase inhibitors.
Arthur G, Cox, Vasu, Nair
openaire +2 more sources
Major revision version 13.0 of the European AIDS Clinical Society guidelines 2025
HIV Medicine, Volume 27, Issue 1, Page 18-32, January 2026.Abstract Background The European AIDS Clinical Society (EACS) guidelines were revised for the 21st time in 2025, with updates covering all aspects of HIV care. Key Points of the Guidelines Update The structure of the guidelines has been reorganized into two parts: Part I focuses on the management and prevention of HIV and related infections, and Part ...
Juan Ambrosioni +19 more
wiley +1 more source
Lipid abnormality correction by integrase inhibitor among children taking ARt
Журнал инфектологии, 2019 Goal. To estimate a possibility of correction laboratory abnormalities (increased level of cholesterol and/or triglycerides at blood of HIV-positive children) by switch the boosted PI on HIV integrase inhibitor (Raltegravir). Methods.
A. V. Samarina +5 more
doaj +1 more source
Impact on weight of a Doravirine switch in people living with HIV
HIV Medicine, Volume 27, Issue 1, Page 136-145, January 2026.Abstract Background and Objective Doravirine is among the first‐line recommended treatments for people living with HIV (PLHIV) in the 2025 EACS guidelines. As opposed to tenofovir alafenamide or anti‐integrase, its use was not associated with weight gain in clinical trials, but limited data are currently available in real life. In this cohort study, we
Nina Garofoli +7 more
wiley +1 more source
VirusesRetroviruses perpetuate their survival by incorporating a copy of their genome into the host cell, a critical step catalyzed by the virally encoded integrase.
Irene Wanjiru Kiarie +6 more
doaj +1 more source
Assessment of Integration-defective HIV-1 and EIAV Vectors In Vitro and In Vivo
Molecular Therapy: Nucleic Acids, 2012 The interest in integrase-defective lentiviral vectors (IDLVs) stems from their potential advantage of large cloning capacity and broad cell tropism while avoiding the possibility of insertional mutagenesis.
Scott Ellis +5 more
doaj +1 more source
Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures. [PDF]
Front Mol Neurosci, 2023 Monnerie H +6 more
europepmc +1 more source
Health Benefits and Therapeutic Potential of Quercetin
Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley +1 more source