Results 41 to 50 of about 45,597 (259)

Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication

Virology Journal, 2019
Background HIV-1 hijacks the cellular machinery for its own replication through protein-protein interactions between viral and host cell factors. One strategy against HIV-1 infection is thus to target these key protein complexes.
Fadila Larguet, Clément Caté, Benoit Barbeau, Eric Rassart, Elsy Edouard   +4 more
doaj   +1 more source

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
core   +1 more source

Fungal Phenalenones Inhibit HIV-1 Integrase [PDF]

The Journal of Antibiotics, 2005
A phenalenone compound, atrovenetinone methyl acetal, was isolated from a culture broth of Penicillium sp. FKI-1463 as an HIV-1 integrase inhibitor, and it showed anti-HIV activity in vitro. HIV-1 integrase inhibition and anti-HIV activity of two other natural phenalenones were also studied.
Kazuro, Shiomi, Ryosuke, Matsui, Miki, Isozaki, Harumi, Chiba, Takahiro, Sugai, Yuichi, Yamaguchi, Rokuro, Masuma, Hiroshi, Tomoda, Tomoko, Chiba, Hua, Yan, Yoshihiro, Kitamura, Wataru, Sugiura, Satoshi, Omura, Haruo, Tanaka   +13 more
openaire   +2 more sources

Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors

European Journal of Medicinal Chemistry Reports
Acquired immune deficiency syndrome (AIDS) diseases despite the efficacy of anti-HIV therapy, remain one of the human's most serious problems. Hence, the introduction of novel anti-HIV agents as first-line therapy is still required. HIV integrase lacking
Nafiseh Karimi, Amirreza Dowlati Beirami, Rouhollah Vahabpour Roudsari, Zahra Hajimahdi, Afshin Zarghi   +4 more
doaj   +1 more source

HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana

Viruses, 2021
There are limited real-world mutational and virological outcomes data of treatment-experienced persons diagnosed with HIV-1 subtype C (HIV-1 C) who are failing Integrase Strand Transfer Inhibitor-based regimens. Requisition forms sent for HIV-1 genotypic
Kaelo K. Seatla, Dorcas Maruapula, Wonderful T. Choga, Tshenolo Ntsipe, Nametso Mathiba, Mompati Mogwele, Max Kapanda, Bornapate Nkomo, Dinah Ramaabya, Joseph Makhema, Mompati Mmalane, Madisa Mine, Ishmael Kasvosve, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe   +15 more
doaj   +1 more source

Integrating transposable elements in the 3D genome [PDF]

, 2019
Chromosome organisation is increasingly recognised as an essential component of genome regulation, cell fate and cell health. Within the realm of transposable elements (TEs) however, the spatial information of how genomes are folded is still only rarely ...
A Bousios, A Bridier-Nahmias, A Buckle, A Ciuffi, A Cournac, A Le Rouzic, AE Hafner, AL Sanborn, AN Boettiger, AP Wolffe, ARW Schroder, B Bonev, B Charlesworth, B Marini, C Vara, C Xue, CA Brackley, CA Brackley, CA Brackley, CA Brackley, CM Caragine, CP Brangwynne, CP Brangwynne, D Jost, D Michieletto, D Michieletto, D Michieletto, D Michieletto, D Pruss, D Pruss, D Schmidt, DG Schatz, DH Sanchez, DJ Winter, E Lieberman-Aiden, E Orlandini, E Serrao, EB Chuong, EP Nora, F Benedetti, F Erdel, G Fudenberg, G Kunarso, GP Wang, H Zayed, HE Lee, Horng D. Ou, I Solovei, IM Flyamer, J Dekker, J Kind, J Nuebler, J Wang, JH Sun, JM Santos-Pereira, Jonathan D Halverson, JR Dixon, JS Lucas, K Roessler, KD Taganov, KG Alavattam, KL Chan, L Hilbert, L Lu, LA Mirny, Lindsay M. Payer, M Benleulmi, M Chiang, M Ciubotaru, M Di Pierro, M Eltsov, M Kvaratskhelia, M Naughtin, M Pasi, MN Choudhary, N Gilbert, N Khanna, P Dong, PJ Flory, PM Pryciak, PS Schnable, R Collepardo-Guevara, R Craigie, R Raviram, R Schrijvers, R Stadhouders, R Stadhouders, R-s Nozawa, S Bianco, S Cheung, S Grob, S Zhou, SSP Rao, SSP Rao, T Cremer, T Nagano, T Sultana, T Wicker, TH Eickbush, V Aidinis, W-K Cho, X Gao, Y Shin, Y Zhang, YAG Fosado, Özgen Deniz   +105 more
core   +5 more sources

Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART

Infectious Disease Reports, 2022
HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance.
Helene Mens, Lasse Fjordside, Jannik Fonager, Jan Gerstoft   +3 more
doaj   +1 more source

ING116070: a study of the pharmacokinetics and antiviral activity of dolutegravir in cerebrospinal fluid in HIV-1-infected, antiretroviral therapy-naive subjects. [PDF]

, 2014
BackgroundDolutegravir (DTG), a once-daily, human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, was evaluated for distribution and antiviral activity in cerebrospinal fluid (CSF).MethodsING116070 is an ongoing, single-arm, open-label ...
Chen, Shuguang, extended ING116070 study team, Letendre, Scott L, Mills, Anthony M, Min, Sherene S, Piscitelli, Stephen C, Song, Ivy H, Tashima, Karen T, Thomas, Deborah A   +8 more
core   +3 more sources

CoMFA and CoMSIA Studies on Inhibitors of HIV-1 Integrase - Bicyclic Pyrimidinones

E-Journal of Chemistry, 2010
To understand the structural requirements of HIV-1 integrase inhibitors and to design new ligands against human HIV-1 integrase with enhanced inhibitory potency, a 3D QSAR (quantitative structure-activity relationship) study with comparative molecular ...
V. Radhika, S. Sree Kanth, M. Vijjulatha
doaj   +1 more source

Integrase Inhibitor Prodrugs: Approaches to Enhancing the Anti-HIV Activity of β-Diketo Acids

Molecules, 2015
HIV integrase, encoded at the 3′-end of the HIV pol gene, is essential for HIV replication. This enzyme catalyzes the incorporation of HIV DNA into human DNA, which represents the point of “no-return” in HIV infection.
Vasu Nair, Maurice Okello
doaj   +1 more source