Results 101 to 110 of about 28,079 (244)

Pyrone-based inhibitors of metalloproteinase types 2 and 3 may work as conformation-selective inhibitors. [PDF]

, 2011
Matrix metalloproteinases are zinc-containing enzymes capable of degrading all components of the extracellular matrix. Owing to their role in human disease, matrix metalloproteinase have been the subject of extensive study.
de Oliveira, César AF, Durrant, Jacob D, McCammon, J Andrew   +2 more
core   +1 more source

HIV drug resistance, early treatment outcomes and impact of guidelines compliance after protease inhibitor‐based second‐line failure in a dedicated resistance clinic in western Kenya: a retrospective cohort study

Journal of the International AIDS Society, Volume 28, Issue 6, June 2025.
Abstract Introduction Data on drug resistance, viral outcomes and guidelines compliance following protease inhibitor (PI)‐based second‐line failure in low‐ and middle‐income countries are limited, particularly in the era of dolutegravir‐containing antiretroviral therapy (ART). Methods We conducted a retrospective cohort study of people living with HIV (
John M. Humphrey, Shamim M. Ali, Allison DeLong, Vlad Novitsky, Edwin Sang, Bilal Jawed, Emmanuel Kemboi, Celia Ngetich, Suzanne Goodrich, Adrian Gardner, Joseph W. Hogan, Rami Kantor   +11 more
wiley   +1 more source

Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives

Molecules, 2010
Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide ...
Li-Ming Hu, Jian-Jun Tan, Cheng-Chu Zeng, Hong-Qiu He, Zi-Guo Jiao, Cun-Xin Wang   +5 more
doaj   +1 more source

Efficacy and safety of bictegravir/emtricitabine/tenofovir alafenamide in Black and Hispanic/Latine adults with HIV‐1 initiating first‐line therapy: 5‐year follow‐up from two phase III studies

HIV Medicine, Volume 26, Issue 6, Page 858-869, June 2025.
Abstract Introduction Black and Hispanic/Latine people are disproportionately affected by HIV‐1 and may have a greater risk of comorbidities than non‐Black and non‐Hispanic/Latine people with HIV. However, they have historically been underrepresented in HIV clinical studies.
C. Martorell, M. Ramgopal, D. Hagins, O. Osiyemi, J. R. Arribas, M. Berhe, Y. Yazdanpanah, C. Orkin, L. Santiago, C. Rosero, N. Unger, H. Liu, R. Rogers, J. T. Hindman, A. Wurapa   +14 more
wiley   +1 more source

First report of computational protein-ligand docking to evaluate susceptibility to HIV integrase inhibitors in HIV-infected Iranian patients. [PDF]

Biochem Biophys Rep, 2022
Ghasabi F, Hashempour A, Khodadad N, Bemani S, Keshani P, Shekiba MJ, Hasanshahi Z.   +6 more
europepmc   +1 more source

A rapid and convergent synthesis of the integrastatin core [PDF]

, 2011
The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapidmanner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product ...
Bugga, Pradeep, Stoltz, Brian M., Tadross, Pamela M.   +2 more
core   +2 more sources

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase [PDF]

, 2015
Background: Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an important new class of anti-HIV-1 agents. ALLINIs bind at the IN catalytic core domain (CCD) dimer interface occupying the principal binding pocket of its cellular cofactor LEDGF/p75.
Deng, Nanjie, Engelman, Alan, Fadel, Hind J, Feng, Lei, Fuchs, James R, Jena, Nivedita, Jurado, Kellie A, Kessl, Jacques J, Kvaratskhelia, Mamuka, Larue, Ross C, Levy, Ronald M, Patel, Pratiq A, Poeschla, Eric, Shkriabai, Nikoloz, Slaughter, Alison   +14 more
core   +1 more source

Rethinking HIV treatment: How non‐integrase strand regimens may hold the key to better immune health

HIV Medicine, Volume 26, Issue 6, Page 879-887, June 2025.
Abstract Purpose HIV outcome changed drastically with antiretroviral (ARV) therapy, especially after the introduction of second‐generation integrase strand transfer inhibitors (INSTIs). Despite these advances, however, chronic immune activation and exhaustion, marked by programmed cell death 1 (PD‐1) and programmed death ligand 1 (PD‐L1) upregulation ...
Bogusz Aksak‐Wąs, Karolina Skonieczna‐Żydecka, Miłosz Parczewski, Rafał Hrynkiewicz, Filip Lewandowski, Karol Serwin, Kaja Mielczak, Franciszek Lenkiewicz, Paulina Niedźwiedzka‐Rystwej   +8 more
wiley   +1 more source

Frequency of Major Transmitted Integrase Resistance in Poland Remains Low Despite Change in Subtype Variability

Viruses
With the widespread use of integrase inhibitors and the expanding use of long-acting cabotegravir in both pre-exposure prophylaxis and antiretroviral treatment, molecular surveillance on the transmission of integrase resistance has regained clinical ...
Kaja Mielczak, Karol Serwin, Anna Urbańska, Bogusz Aksak-Wąs, Malwina Karasińska-Cieślak, Elżbieta Mularska, Adam Witor, Paweł Jakubowski, Maria Hlebowicz, Monika Bociąga-Jasik, Elżbieta Jabłonowska, Aleksandra Szymczak, Bartosz Szetela, Władysław Łojewski, Miłosz Parczewski   +14 more
doaj   +1 more source

Inhibition of Adipose Tissue Beiging by HIV Integrase Inhibitors, Dolutegravir and Bictegravir, Is Associated with Adipocyte Hypertrophy, Hypoxia, Elevated Fibrosis, and Insulin Resistance in Simian Adipose Tissue and Human Adipocytes. [PDF]

Cells, 2022
Ngono Ayissi K, Gorwood J, Le Pelletier L, Bourgeois C, Beaupère C, Auclair M, Foresti R, Motterlini R, Atlan M, Barrail-Tran A, Le Grand R, Desjardins D, Fève B, Lambotte O, Capeau J, Béréziat V, Lagathu C.   +16 more
europepmc   +1 more source