Results 101 to 110 of about 71,892 (273)

A Fluorescent Assay to Search for Inhibitors of HIV-1 Integrase Interactions with Human Ku70 Protein, and Its Application for Characterization of Oligonucleotide Inhibitors

Biomolecules, 2020
The search for compounds that can inhibit the interaction of certain viral proteins with their cellular partners is a promising trend in the development of antiviral drugs.
Simon Galkin, Anna Rozina, Arthur Zalevsky, Marina Gottikh, Andrey Anisenko   +4 more
doaj   +1 more source

Agreement between an in‐house replication competent and a reference replication defective recombinant virus assay for measuring phenotypic resistance to HIV‐1 protease, reverse transcriptase, and integrase inhibitors

Journal of clinical laboratory analysis (Print), 2018
Although clinical management of drug resistance is routinely based on genotypic methods, phenotypic assays remain necessary for the characterization of novel HIV‐1 inhibitors, particularly against common drug‐resistant variants.
F. Saladini, Alessia Giannini, A. Boccuto, I. Vicenti, M. Zazzi   +4 more
semanticscholar   +1 more source

HIV and Non‐HIV Patients Have Similar Rates of Neoplastic Findings on Screening Colonoscopy Within a Predominantly African American Cohort

Cancer Medicine, Volume 14, Issue 8, April 2025.
ABSTRACT Introduction With the reduction in human immunodeficiency virus (HIV)–related mortality secondary to antiretroviral therapy, chronic medical conditions and age‐related cancers account for a larger proportion of mortality among those with HIV. Cancer risk overall remains elevated in HIV patients, and cancer screening data in this population is ...
Pooja Mude, Alexandra E. Thomson, Lavannya Atri, Samantha Newman, Carlos Palacio, John Erikson L. Yap, Christian S. Jackson, Kenneth J. Vega   +7 more
wiley   +1 more source

Maraviroc (Celsentri) in HIV treatment

Farmeconomia: Health Economics and Therapeutic Pathways, 2008
Since 1996, the prognosis of people living with immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) has improved significantly, due to highly active antiretroviral therapies (HAART) based on a combination of 3-4 anti-HIV drugs; the
Viola Sacchi
doaj   +1 more source

Application of Bootstrap Re-sampling Method to a Categorical Data of HIV/AIDS Spread across different Social-Economic Classes [PDF]

, 2016
This research reports on the relationship and significance of social-economic factors (age, sex, employment status) and modes of HIV/AIDS transmission to the HIV/AIDS spread. Logistic regression model, a form of probabilistic function for binary response was used to relate social-economic factors (age, sex, employment status) to HIV/AIDS spread.
arxiv   +1 more source

HIV-1 Integrase Inhibitors That Are Broadly Effective against Drug-Resistant Mutants

Antimicrobial Agents and Chemotherapy, 2018
Integrase strand transfer inhibitors (INSTIs) have emerged as clinically effective therapeutics that inhibit HIV-1 replication by blocking the strand transfer reaction catalyzed by HIV-1 integrase (IN). Of the three FDA-approved INSTIs, dolutegravir (DTG)
Steven J. Smith, X. Zhao, T. Burke, S. Hughes   +3 more
semanticscholar   +1 more source

Addressing Cardiometabolic Challenges in HIV: Insights, Impact, and Best Practices for Optimal Management—A Narrative Review

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Introduction Since the advent of highly active antiretroviral therapy (HAART), morbidity and mortality rates associated with human immunodeficiency virus (HIV) have significantly decreased leading to prolonged life span of Individuals living with HIV due to the effectiveness of antiretroviral therapy.
Nadine Mugisha, Laura Ghanem, Omar A. I. Komi, Rawan Noureddine, Sanobar Shariff, Magda Wojtara, Mahlagha Mousavi Nanehkeran, Olivier Uwishema   +7 more
wiley   +1 more source

A remarkable emergent property of spontaneous (amino acid content) symmetry breaking [PDF]

arXiv, 2012
Learning how proteins fold will hardly have any impact in the way conventional -- active site centered -- drugs are designed. On the other hand, this knowledge is proving instrumental in defining a new paradigm for the identification of drugs against any target protein: folding inhibition.
arxiv  

Tangle Solutions for a Family of DNA-Rearranging Proteins [PDF]

, 2004
We study two systems of tangle equations that arise when modeling the action of the Integrase family of proteins on DNA. These two systems--direct and inverted repeats--correspond to two different possibilities for the initial DNA sequence. We present one new class of solutions to the tangle equations.
arxiv   +1 more source

Differences in clinical characteristics between adolescents and young adults with perinatally and sexually acquired HIV in the Asia‐Pacific region

Journal of the International AIDS Society, Volume 28, Issue 4, April 2025.
Abstract Introduction We assessed the long‐term HIV‐related health outcomes of young adults with perinatally acquired HIV (PHIV) compared with those who acquired HIV through sexual transmission in the Asia‐Pacific region. Methods We conducted a cross‐sectional study using data from three paediatric and adult cohorts within the International ...
Phatharajit Phatharodom, Alan Maleesatharn, Tavitiya Sudjaritruk, Suwimon Khusuwan, Kathy Petoumenos, Linda Aurpibul, Romanee Chaiwarith, Michelle L. Giles, Du Tuan Quy, Smita Nimkar, Alvina Widhani, Junko Tanuma, Matthew Law, Annette H. Sohn, Kulkanya Chokephaibulkit, IeDEA Asia‐Pacific   +15 more
wiley   +1 more source