Results 101 to 110 of about 28,540 (254)

Weight gain on tenofovir alafenamide fumarate‐based therapy compared to tenofovir disoproxil fumarate‐ and abacavir‐based therapy in children and young people living with HIV in Europe

HIV Medicine, EarlyView.
Abstract Objective To compare BMI‐for‐age z‐score (zBMI) changes in treatment‐experienced children and young people living with HIV aged 6 to <25 years on tenofovir alafenamide fumarate (TAF) to those on tenofovir disoproxil fumarate (TDF) and abacavir (ABC).
The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) Study Group, Siobhan Crichton, Hannah Castro, Katja Doerholt, Luminita Ene, Luisa Galli, Tessa Goetghebuer, Sannie Brit Nordly, Christoph Königs, Magdalena Marczynska, Andrea Marongiu, Lars Navér, Marisa Navarro, Antoni Noguera‐Julian, Paolo Paioni, Vana Spoulou, Vinicius Vieira, Charlotte Jackson, Intira Jeannie Collins, Ali Judd, Elizabeth Chappell, Laura Calle Miguel, Borja Guarch‐Ibáñez, John O'Rourke, Katia Prime, Beatriz Ruiz‐Saez, Sandra Soeria‐Atmadja, Anna Turkova   +27 more
wiley   +1 more source

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase [PDF]

, 2015
Background: Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an important new class of anti-HIV-1 agents. ALLINIs bind at the IN catalytic core domain (CCD) dimer interface occupying the principal binding pocket of its cellular cofactor LEDGF/p75.
Deng, Nanjie, Engelman, Alan, Fadel, Hind J, Feng, Lei, Fuchs, James R, Jena, Nivedita, Jurado, Kellie A, Kessl, Jacques J, Kvaratskhelia, Mamuka, Larue, Ross C, Levy, Ronald M, Patel, Pratiq A, Poeschla, Eric, Shkriabai, Nikoloz, Slaughter, Alison   +14 more
core   +1 more source

Metabolic dysfunction‐associated liver disease predicts incident liver fibrosis in people with HIV mono‐infection: A cohort study

HIV Medicine, EarlyView.
Abstract Introduction Metabolic dysfunction‐associated liver disease (MASLD) might progress to cirrhosis. We aimed to evaluate the association of MASLD with the risk of developing clinically significant fibrosis (CSF) in people living with HIV (PLWH).
Juliana Fittipaldi, Sandra W. Cardoso, Estevão Portela Nunes, Cristiane Fonseca De Almeida, Patricia Dias De Brito, Valdilea G. Veloso, Beatriz Grinsztejn, Hugo Perazzo   +7 more
wiley   +1 more source

The association between HIV drug resistance testing, viral suppression and mortality in Ontario: a retrospective cohort study

HIV Medicine, EarlyView.
Abstract Background Drug resistance compromises the effectiveness of antiretroviral therapy (ART). Resistance testing prior to initiating therapy is recommended in guidelines in many high‐income countries, and it has been shown to improve outcomes after first‐line ART regimen failure. There is limited evidence on its role in treatment‐naïve individuals.
Lawrence Mbuagbaw, Carmen H. Logie, Lehana Thabane, Fiona Smaill, Marek Smieja, Ann N. Burchell, Beth Rachlis, Jean Eric Tarride, Abigail E. Kroch, Tony Mazzulli, Elizabeth Alvarez, Francis Nguyen, Richard Perez, Cristian Garcia, Jessyca Matos Silva, Hsien Seow   +15 more
wiley   +1 more source

Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives

Molecules, 2010
Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide ...
Li-Ming Hu, Jian-Jun Tan, Cheng-Chu Zeng, Hong-Qiu He, Zi-Guo Jiao, Cun-Xin Wang   +5 more
doaj   +1 more source

A rapid and convergent synthesis of the integrastatin core [PDF]

, 2011
The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapidmanner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product ...
Bugga, Pradeep, Stoltz, Brian M., Tadross, Pamela M.   +2 more
core   +2 more sources

Cardiovascular risk knowledge stratified by predicted cardiovascular risk level among people living with HIV attending a tertiary HIV care centre in Gaborone, Botswana: A cross‐sectional study

HIV Medicine, EarlyView.
Abstract Objectives While people living with HIV are at an increased risk of cardiovascular disease (CVD), the level of awareness of CVD risk in this population is not well documented. This study aimed to assess the association between CVD risk factor knowledge and estimated CVD risk among people living with HIV.
Bernard Morapedi, Onkabetse Julia Molefe‐Baikai, Onkarabile Hiri, Kago Kebotsamang, Thato Moshomo, Mosepele Mosepele   +5 more
wiley   +1 more source

Frequency of Major Transmitted Integrase Resistance in Poland Remains Low Despite Change in Subtype Variability

Viruses
With the widespread use of integrase inhibitors and the expanding use of long-acting cabotegravir in both pre-exposure prophylaxis and antiretroviral treatment, molecular surveillance on the transmission of integrase resistance has regained clinical ...
Kaja Mielczak, Karol Serwin, Anna Urbańska, Bogusz Aksak-Wąs, Malwina Karasińska-Cieślak, Elżbieta Mularska, Adam Witor, Paweł Jakubowski, Maria Hlebowicz, Monika Bociąga-Jasik, Elżbieta Jabłonowska, Aleksandra Szymczak, Bartosz Szetela, Władysław Łojewski, Miłosz Parczewski   +14 more
doaj   +1 more source

Comparative replication capacity of raltegravir-resistant strains and antiviral activity of the new-generation integrase inhibitor dolutegravir in human primary macrophages and lymphocytes [PDF]

, 2014
To evaluate the replication capacity and phenotypic susceptibility to dolutegravir and raltegravir of wild-type and raltegravir-resistant HIV-1 strains in several cellular ...
Calvez, V, Ceccherini-Silberstein, F, Cortese, Mf, di Santo, F, Fabeni, L, Fedele, V, Malet, I, Marcelin, A-, Perno, CF, Pollicita, M, Surdo, M, Svicher, V   +11 more
core   +1 more source

Leukocyte count and new‐onset diabetes mellitus in people with HIV: A longitudinal study

HIV Medicine, EarlyView.
Abstract Objectives The risk of diabetes mellitus (DM) is increased in people with HIV. Chronic inflammation contributes to DM risk. High leukocytes are associated with DM in the general population, but in people with HIV, evidence of a leukocyte–DM association is limited. Methods We included participants of the Swiss HIV Cohort Study with new‐onset DM
Sophia C. Meyer, Zoe Klein, Isabella C. Schoepf, Christian W. Thorball, Marco Labarile, Neeltje A. Kootstra, Peter Reiss, Lene Ryom, Dominique L. Braun, Maria C. Thurnheer, Catia Marzolini, Christian R. Kahlert, Enos Bernasconi, Matthias Cavassini, Annalisa Marinosci, Jacques Fellay, Huldrych F. Günthard, Roger D. Kouyos, Bruno Ledergerber, Philip E. Tarr, the Swiss HIV Cohort Study, I Abela, K Aebi‐Popp, A Anagnostopoulos, M Battegay, E Bernasconi, DL Braun, HC Bucher, A Calmy, M Cavassini, A Ciuffi, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, CA Fux, HF Günthard, A Hachfeld, D Haerry, B Hasse, HH Hirsch, M Hoffmann, I Hösli, M Huber, D Jackson‐Perry, patient representatives, CR Kahlert, O Keiser, T Klimkait, RD Kouyos, H Kovari, K Kusejko, N Labhardt, K Leuzinger, B Martinez de Tejada, C Marzolini, KJ Metzner, N Müller, J Nemeth, D Nicca, J Notter, P Paioni, G Pantaleo, M Perreau, A Rauch, L Salazar‐Vizcaya, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, G Wandeler, M Weisser, S. Yerly   +75 more
wiley   +1 more source