Results 121 to 130 of about 86,566 (299)

HIV/HCV-coinfection: which role can new antiretrovirals such as integrase inhibitors play?

European Journal of Medical Research, 2009
End-stage liver disease has become one of the most frequent causes of death in HIV/HCV-coinfected patients. The role of new antiretrovirals in the progression of liver fibrosis has yet to be defined.
Vogel Martin, Nelson Mark
doaj   +1 more source

Computational structure‐based drug design: Predicting target flexibility [PDF]

, 2018
The role of molecular modeling in drug design has experienced a significant revamp in the last decade. The increase in computational resources and molecular models, along with software developments, is finally introducing a competitive advantage in early
Ding X., Dreher J., Khago D., Li Y., Samuel G.   +4 more
core   +2 more sources

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source

From ligand to complexes: inhibition of HIV-1 Integrase by beta-diketo acid metal complexes [PDF]

, 2006
Recently, a class of compounds bearing a β-diketo acid moiety have emerged as the most promising lead in anti-HIV-1 IN drug discovery. It is believed that the β-diketo acid pharmacophoric motif could be involved in a functional sequestration of one or ...
Al-Mawsawi, Laith Q., Bacchi, Alessia, Carcelli, Mauro, Derudas, Marco, Fisicaro, Emilia, Gates, Paul, Neamati, Nouri, Rogolino, Dominga, Sechi, Mario   +8 more
core  

Synthesis, molecular modeling and biological evaluation of two new chicoric acid analogs [PDF]

, 2016
Two conformationally constrained compounds similar to chicoric acid but lacking the catechol and carboxyl groups were prepared. In these analogues, the single bond between the two caffeoyl fragments has been replaced with a chiral oxirane ring and both ...
Bovicelli, P, Dallocchio, R, Dessì, A, Frezza, C, Isoni, V, Macchi, B, Pelagalli, R, Righi, G, Rossetti, I, Tirotta, I   +9 more
core   +1 more source

Prevalence of Primary Drug Resistance Against HIV-1 Integrase Inhibitors in Canada

Journal of Acquired Immune Deficiency Syndromes, 2018
To the Editors: An estimated 36.9 million people are living with HIV-1 worldwide,1 of which there are approximately 75,500 infected people in Canada.2 Although varied prevention strategies have been successful in reducing the HIV-1 incidence,3 over 2000 ...
H. Ji, A. Patterson, Tracy Taylor, C. Rank, J. Halverson, R. Capina, J. Brooks, P. Sandstrom   +7 more
semanticscholar   +1 more source

Bee products as alternatives in the treatment of viral infections

Journal of the Science of Food and Agriculture, Volume 106, Issue 1, Page 33-54, 15 January 2026.
Abstract Medicines used in the treatment of viral infections usually reduce symptoms. There is a need to develop drugs that inhibit the viruses and do not merely relieve the symptoms. Natural bee products possess many pharmacological properties and are widely used in folk medicine. There are many studies on the antibacterial effects of bee products but
Michał Otręba, Łukasz Marek, Jerzy Stojko, Anna Rzepecka‐Stojko   +3 more
wiley   +1 more source

Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years and older: The AGING POSITIVE study. [PDF]

, 2018
OBJECTIVE: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC.
Abreu, R, Almeida, J, Castro, R, Coutinho, D, Lino, S, Lopes, MJ, Maltez, F, Mansinho, K, Miranda, AC, Neves, I, Pacheco, P, Piñero, C, Pássaro, L, Sarmento, E, Serrão, R, Tavares, AP, Velez, J   +16 more
core   +1 more source

Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa

Scientific Reports, 2018
HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to characterize the HIV-1 IN gene in a South African context and identify resistance-associated mutations (RAMs) against available first and second generation
Dominik Brado, A. Obasa, G. Ikomey, Ruben Cloete, Kamalendra Singh, S. Engelbrecht, U. Neogi, G. Jacobs   +7 more
semanticscholar   +1 more source

Blood‐based Alzheimer's disease biomarkers and cognitive trajectories in older people with HIV with undetectable viral loads

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Cognitive impairment among people with HIV (PWH) remains common, yet underlying mechanisms remain unclear. Alzheimer's disease (AD) is the leading cause of dementia, and blood‐based biomarkers offer a promising diagnostic alternative.
Akarin Hiransuthikul, Poosanu Thanapornsangsuth, Watayuth Luechaipanit, Thanaporn Haethaisong, Sasiwimol Ubolyam, Tanakorn Apornpong, Win Min Han, Stephen Kerr, Anchalee Avihingsanon, HIV‐NAT 006 and 207 study team   +9 more
wiley   +1 more source