Hiv integrase inhibitors - Open Access .click

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Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors

Molecules, 2011
Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). In recent years our research group has been engaged in the stucture-function study of this enzyme and in the development
Alba Chimirri +6 more
doaj +1 more source

Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric Carboxy-Terminal Domain Interactions. [PDF]

Structure, 2021
Gupta K +10 more
europepmc +1 more source

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors

Journal of Medicinal Chemistry, 2017
Integrase mutations can reduce the effectiveness of the first-generation FDA-approved integrase strand transfer inhibitors (INSTIs), raltegravir (RAL) and elvitegravir (EVG).
X. Zhao +10 more
semanticscholar +1 more source

HIV Medicine, Volume 26, Issue 4, Page 606-620, April 2025.
Abstract Objectives We aimed to describe health‐related quality of life (HRQoL), overall and across its dimensions, identify associated factors, and assess changes over time among people with HIV (PWH) from the Spanish multicentre CoRIS cohort.
Rebeca Izquierdo +429 more
wiley +1 more source

Impact of HBV serological status on HIV virological efficacy of two‐drug antiretroviral regimens: A retrospective observational study on virologically suppressed people with HIV switching to lamivudine/dolutegravir

HIV Medicine, Volume 26, Issue 4, Page 650-653, April 2025.
Abstract Objectives This study aimed to evaluate the HIV virological efficacy of two‐drug regimens (2DR) with lamivudine (3TC) and dolutegravir (DTG) in people with HIV (PWH), classified by their hepatitis B virus (HBV) serological status. Specifically, it explored whether isolated anti‐hepatitis B core (anti‐HBc) positivity impacts virological ...
Pierluigi Francesco Salvo +6 more
wiley +1 more source

Potential benefit of dolutegravir once daily: efficacy and safety

HIV/AIDS: Research and Palliative Care, 2013
Alessandra Fantauzzi,1 Ombretta Turriziani,2 Ivano Mezzaroma11Department of Clinical Medicine, 2Department of Molecular Medicine, Sapienza, University of Rome, Rome, ItalyAbstract: The viral integrase enzyme has recently emerged as a primary alternative ...
Fantauzzi A, Turriziani O, Mezzaroma I
doaj

In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors

Advances in Virology, 2012
Most antiretroviral medical treatments were developed and tested principally on HIV-1 B nonrecombinant strain, which represents less than 10% of the worldwide HIV-1-infected population.
Xiaoju Ni +8 more
doaj +1 more source

Primary resistance to integrase strand transfer inhibitors in patients infected with diverse HIV-1 subtypes in sub-Saharan Africa

Journal of Antimicrobial Chemotherapy, 2018
Objectives To investigate the prevalence and patterns of major and accessory resistance mutations associated with integrase strand transfer inhibitors (INSTIs), across diverse HIV-1 subtypes in sub-Saharan Africa.
S. Inzaule +6 more
semanticscholar +1 more source

The Coalescence of Intrahost HIV Lineages Under Symmetric CTL Attack [PDF]

arXiv, 2011
Cytotoxic T lymphocytes (CTLs) are immune system cells that are thought to play an important role in controlling HIV infection. We develop a stochastic ODE model of HIV-CTL interaction that extends current deterministic ODE models. Based on this stochastic model, we consider the effect of CTL attack on intrahost HIV lineages assuming CTLs attack ...
arxiv

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase [PDF]

, 2000
Amy S. Espeseth +11 more
openalex +1 more source

medicine
biology
integrase

chemistry
antiretroviral therapy
human immunodeficiency virus hiv

integrase inhibitor
viral load
virology