Results 241 to 250 of about 32,363 (272)
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Epigenetic regulation of HIV latency
Current Opinion in HIV and AIDS, 2011A reservoir of latently infected cells remains in HIV-infected patients treated with highly active antiretroviral therapy treatment. Persistence of HIV in this latent reservoir has prevented full viral eradication. In order to understand and develop rational therapeutics to flush out HIV latency, the molecular mechanisms governing the phenomena of HIV ...
Shweta, Hakre +3 more
openaire +2 more sources
HIV replication and latency in monocytes and macrophages
Seminars in Immunology, 2021The relevance of monocyte and macrophage reservoirs in virally suppressed people with HIV (vsPWH) has previously been debatable. Macrophages were assumed to have a moderate life span and lack self-renewing potential. However, recent studies have challenged this dogma and now suggest an important role of these cell as long-lived HIV reservoirs ...
Rebecca T. Veenhuis +4 more
openaire +2 more sources
AIDS, 1992
This review describes some of the virus-cell relationships that might contribute to the state of latency observed in HIV infection. Viruses use many mechanisms to persist in their host, and the molecular interactions evoked by the virus and the cell on each other can influence the outcome of an infection.
D P, Bednarik, T M, Folks
openaire +2 more sources
This review describes some of the virus-cell relationships that might contribute to the state of latency observed in HIV infection. Viruses use many mechanisms to persist in their host, and the molecular interactions evoked by the virus and the cell on each other can influence the outcome of an infection.
D P, Bednarik, T M, Folks
openaire +2 more sources
The Molecular Biology of HIV Latency
2018HIV remains incurable due to the existence of a reservoir of cells that harbor intact integrated genomes of the virus in the absence of viral replication. This population of infected cells remains invisible to the immune system and is not targeted by the drugs used in the current antiretroviral therapies (cART).
Khoury, Georges +6 more
openaire +4 more sources
Cellular Latency in HIV-1 Infection
Clinics in Laboratory Medicine, 1994There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1 LTR.
M A, Laughlin, R J, Pomerantz
openaire +2 more sources
A unified concept of HIV latency
Expert Opinion on Biological Therapy, 2006The introduction of highly active antiretroviral therapy (HAART) combining potent drugs that can inhibit reverse transcriptase, integrase and protease activities has changed the natural history of the human immunodeficiency virus (HIV) type 1 disease. Unfortunately, poor penetrability into different anatomic compartments, toxicity and drug resistance ...
openaire +2 more sources