Results 231 to 240 of about 32,363 (272)

A macrophage-cell model of HIV latency reveals the unusual importance of the bromodomain axis. [PDF]

Virol J
Kisaka JK, Rauch D, Griffith M, Kyei GB.
europepmc   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Defining the Effects of PKC Modulator HIV Latency-Reversing Agents on Natural Killer Cells. [PDF]

Pathog Immun
Dimapasoc M, Moran JA, Cole SW, Ranjan A, Hourani R, Kim JT, Wender PA, Marsden MD, Zack JA.   +8 more
europepmc   +1 more source

French guidelines on systemic treatments for moderate‐to‐severe psoriasis in adults: Update 2025

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 6, Page 963-979, June 2026.
New 2025 French guidelines update psoriasis management with revised algorithms integrating recent systemic therapies. They recommend methotrexate, adalimumab or ustekinumab as first‐line treatments and provide guidance for special psoriasis forms, comorbidities, pregnancy and long‐term management.
Marie Masson Regnault, Emilie Brenaut, Marie‐Emeline Marniquet, Carla Berthault, Lea Canoen, Clarisse Marcombes, Audrey Melin, Raphaël Ouakrat, Julie Charles, Stephane Mouret, Olivier Potie, Laetitia Penso, Laura Pina Vegas, Guillaume Larid, Marine Roux, Colombe Bougeard, Sandy Sylvain, Clara Labonne, Tania Randriamiarana, Da Hee Pitaud, Floriane Etheve, Jeremy Gottlieb, Laurie Gouillon, Marine Chastagner, Emilie Sbidian, Hélène Aubert, on behalf of the Psoriasis Research Group of the French Society of Dermatology (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), Hélène Aubert, Marie Masson Regnault, Emilie Brenaut, Emilie Sbidian, Laura Pina Vegas, Laetitia Penso, Jeremy Gottlieb, Marine Roux, Clara Labonne, Tania Randriamiarana, Floriane Etheve, Da Hee Pitaud, Marie‐Emeline Marniquet, Carla Berthault, Clarisse Marcombes, Audrey Melin, Colombe Bougeard, Julie Charles, Olivier Potie, Léa Canoen, Laurie Gouillon, Marine Chastagner, Sandy Sylvain, Guillaume Larid, Raphaël Ouakrat   +51 more
wiley   +1 more source

Three novel epigenetic-modifying compounds identified as HIV latency-reversing agents in Ghana

Abana CZ, Boateng AT, Abaidoo-Myles A, Nartey PA, Bortey CB, Quansah DNK, Aboagye JO, Appiah-Opong R, Quaye O, Clark KM, Lamptey H, Shan L, Bonney EY, Kyei GB.   +13 more
europepmc   +1 more source

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

Integrating the In‐Laws: Class and Kin Support Within Marriage in Urban Kenya

Journal of Marriage and Family, Volume 88, Issue 3, Page 777-790, June 2026.
ABSTRACT Objective This study compares affinal kin relationships in low‐income and higher‐income families in Nairobi, Kenya. Background In most studies of kinship structure and relationships in sub‐Saharan Africa, culture serves as the basis upon which norms and expectations of kin are differentiated.
Kirsten Stoebenau, Nikita Viswasam, Estelle M. Sidze, Sangeetha Madhavan   +3 more
wiley   +1 more source

Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation. [PDF]

Genomics Proteomics Bioinformatics
Ashokkumar M, Mei W, Peterson JJ, Harigaya Y, Murdoch DM, Margolis DM, Kornfein C, Oesterling A, Guo Z, Rudin CD, Jiang Y, Browne EP.   +11 more
europepmc   +1 more source

Development and psychometric properties of a general cancer stigma scale

International Journal of Cancer, Volume 158, Issue 10, Page 2747-2759, 15 May 2026.
What's New? Cancer‐related stigma can fuel anxiety and depression and lead to self‐isolation, delayed treatment, and decreased quality of life. The extent to which stigma impacts cancer patients, however, remains uncertain. This study applied mixed methods in high‐ and low‐income settings, with cohorts in the U.S. state of Utah and Lilongwe, Malawi, to
Stephen M. Kimani, Gita Suneja, Agatha Bula, Chaorong Wu, Abhilasha Khatri, Nehal Bakshi, Olivia R. Hanson, Aparna Mangadu, Mercy Tsidya, Melissa A. Stockton, Brandon A. Knettel, Melissa H. Watt   +11 more
wiley   +1 more source

CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells. [PDF]

mBio
Rathore U, Haas P, Easwar Kumar V, Hiatt J, Haas KM, Bouhaddou M, Swaney DL, Stevenson E, Zuliani-Alvarez L, McGregor MJ, Turner-Groth A, Ochieng' Olwal C, Bediako Y, Braberg H, Soucheray M, Ott M, Eckhardt M, Hultquist JF, Marson A, Kaake RM, Krogan NJ.   +20 more
europepmc   +1 more source