Results 211 to 220 of about 32,363 (272)

PACS2 Alleviates Sepsis‐Induced Myopathy by Activating ERK–MAPK Signalling Pathway to Suppress ER‐Phagy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Sepsis‐induced myopathy (SIM) is a common and life‐threatening complication, but its underlying mechanisms remain poorly understood. PACS2, a key resident protein at mitochondria‐associated endoplasmic reticulum membranes (MAMs), regulates ER homeostasis under various pathological conditions.
Xuexin Li, Zu‐an Shi, Fei He, Guo Mu, Feixiang Wang, Bowen Sun, Xiaobin Wang, Li Liu   +7 more
wiley   +1 more source

Comprehensive SUMO Proteomic Analyses Identify HIV Latency-Associated Proteins in Microglia. [PDF]

Cells
Imbert F, Langford D.
europepmc   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Phytochemicals from <i>Euclea natalensis</i> Modulate Th17 Differentiation, HIV Latency, and Comorbid Pathways: A Systems Pharmacology and Thermodynamic Profiling Approach. [PDF]

Microorganisms
Oduro-Kwateng E, Abo-Dya NE, Soliman ME, Mkhwanazi NP.   +3 more
europepmc   +1 more source

Trajectories of Treatment Disruption for Chronic Outpatient Medications for U.S. Veterans During Drug Shortages

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.
ABSTRACT Introduction Although drug shortages for outpatient chronic conditions commonly occur, population‐level data on how they impact patients' ability to refill prescriptions is scarce. We sought to identify distinct patterns of refill adherence following drug shortages and patient‐ and prescription‐level factors associated with adherence ...
Katie J. Suda, Xinhua Zhao, Sherrie L. Aspinall, Yaming Li, Katherine Callaway Kim, Francesca E. Cunningham, Taylor L. Boyer, Tate W. Miner, Clara Kima, Walid F. Gellad, Peter A. Glassman, Chester B. Good, Felicia Skelton, Mina Tadrous, Carolyn T. Thorpe   +14 more
wiley   +1 more source

Commentary on LRAs targeting NF-κB with epigenetic and mutational impacts on HIV latency. [PDF]

IMetaOmics
Chen S.
europepmc   +1 more source

Public Health Implications of High Cytomegalovirus Seroprevalence in Pregnancy: A Cross‐Sectional Study in Western Uganda

Public Health Challenges, Volume 5, Issue 2, June 2026.
Among immediate postpartum women in western Uganda, maternal CMV seroprevalence was high (81.2%) and was predominantly chronic or non‐primary infection. Older age, rural residence, lower education, and prior spontaneous abortion were associated with seropositivity, supporting targeted maternal CMV education and evaluation of context‐appropriate ...
Bashir Mohamed Naima, Marie Pascaline Sabine Ishimwe, Theodore Nteziyaremye, Jean de Dieu Rukamba, Musa Kasujja, Theoneste Hakizimana   +5 more
wiley   +1 more source

A high-throughput, microplate reader-based method to monitor in vitro HIV latency reversal in the absence of flow cytometry. [PDF]

Virology
Nkwelle CE, Stephens U, Liang K, Cassel J, Salvino JM, Montaner LJ, Ndip RN, Esemu SN, Ntie-Kang F, Tietjen I.   +9 more
europepmc   +1 more source

Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications

Small, Volume 22, Issue 33, 12 June 2026.
Particle shape is a key design parameter governing biological interactions. Advances in fabrication enable precise control over anisotropy and compartmentalization, allowing modulation of cellular uptake, transport, and biodistribution, ultimately enhancing therapeutic performance. ABSTRACT Polymer geometry is a primary determinant of physical behavior
Francisca G. Perfeito, Mariana B. Oliveira, João F. Mano   +2 more
wiley   +1 more source

The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2. [PDF]

JCI Insight
Howard JN, Zaikos TD, Levinger C, Rivera E, McMahon EK, Holmberg CS, Terao J, Sanz M, Copertino DC, Wang W, Soriano-Sarabia N, Jones RB, Bosque A.   +12 more
europepmc   +1 more source