Results 141 to 150 of about 118,257 (252)

Hyperlipidaemia - a risk factor for femoral head osteonecrosis (Legg-Calvè-Perthes-Like disease) in children with AIDS: case report

Brazilian Journal of Infectious Diseases
Although treatment of children infected with HIV with protease inhibitors has improved the survival of these patients, various adverse side effects have been reported, including metabolic abnormalities, such as hyperlipidaemia.
Paula Aguiar de Aragão, Renata B. P. Lemos, Maria Zilda Aquino, Heloísa Helena Souza Marques   +3 more
doaj   +1 more source

Combining Small‐Molecular Compounds With CAR T‐Cell Therapy: Novel Strategies for Enhanced Cancer Immunotherapy

Cancer Innovation, Volume 5, Issue 2, April 2026.
Chimeric antigen receptor (CAR) T‐cell therapy, although revolutionary for haematological malignancies, faces significant challenges, including T‐cell exhaustion, limited persistence, and treatment‐related toxicity. The integration of small‐molecule compounds offers a promising strategy to overcome these limitations.
Rangzi Yi, Zijian Zhang, Yang Yang, Haichuan Zhu   +3 more
wiley   +1 more source

Frailty Transition Among Older Adults Living With HIV in Thailand: A 5‐Year Longitudinal Study

Journal of the International AIDS Society, Volume 29, Issue 4, April 2026.
ABSTRACT Introduction Frailty is highly prevalent among older people with HIV (PWH), driven by multimorbidity and HIV‐associated accelerated ageing. We investigated frailty transitions and associated factors over a 5‐year follow‐up period in an ageing cohort of PWH in Thailand. Methods We conducted a prospective cohort study among PWH aged ≥50 years in
Tanakorn Apornpong, Win Min Han, Akarin Hiransuthikul, Hay Mar Su Lwin, Napon Hiranburana, Sasiwimol Ubolyam, Stephen J. Kerr, Thira Woratanarat, Anchalee Avihingsanon, HIV‐NAT 006 and 207 study team   +9 more
wiley   +1 more source

The Flavivirus NS3 Protein: Its Multifaceted Roles and Therapeutic Potential

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
Abstract Mosquito‐borne flaviviruses are important human pathogenic viruses and can cause an array of symptoms ranging from asymptomatic to mild illness but can progress to severe disease conditions. Prominent members of the family Flaviviridae include Dengue virus, Zika virus, and West Nile virus, whose spread has increased globally due to the ...
Haejeong Lee, Hee Cho, Michaela U. Gack
wiley   +1 more source

Decoding HIV‐1 Next Move Through Matrix Protein p17 Quasi‐Species

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
HIV‐1 mutants expressing clonogenic HIV‐1 matrix protein p17 variants (vp17s) are spreading, increasing their prevalence worldwide. In RNA viruses, quasi‐species are transmitted among hosts, leading to the generation of new master sequences. We developed a next‐generation sequence approach to evaluate the frequency of vp17 quasi‐species in people ...
Serena Messali, Anna Bertelli, Marta Giovanetti, Leonardo Sclavi, Massimo Ciccozzi, Mark Slevin, Arnaldo Caruso, Francesca Caccuri   +7 more
wiley   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

HIV Protease Inhibitor [PDF]

, 2020
openaire   +1 more source

Real‐world relationship between blood biomarker‐based PhenoAge, metformin, and Alzheimer's disease

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract INTRODUCTION The biological aging process could be an important Alzheimer's disease (AD) pathogenesis. Metformin might be beneficial in anti‐aging and cognition and has mixed associations with AD and/or dementia. METHODS We used a US nationwide insurance claims dataset. We used Cox models to investigate the relationship between blood biomarker‐
Yi Shi, Anna Sun, Jing Xu, Yuedi Yang, Andrew J. Saykin, Feixiong Cheng, Pengyue Zhang   +6 more
wiley   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Treatment Outcome and Regimens of Lipid-Lowering Drugs among HIV-Infected Patients Receiving Protease Inhibitors

Journal of Health Science and Medical Research (JHSMR), 2016
Objective: To determine treatment outcome and regimens among human immunodeficiency virus (HIV)-infected patients receiving protease inhibitors treated with lipid-lowering drugs.
Krisda Boonthos, Weerawatwat Manosuthi, Thitima Pengsuparp, Chankit Puttilerpong   +3 more
doaj