Results 171 to 180 of about 58,529 (279)

Counteracting Akt Activation by HIV Protease Inhibitors in Monocytes/Macrophages. [PDF]

Viruses, 2018
Pasquereau S, Kumar A, Abbas W, Herbein G.   +3 more
europepmc   +1 more source

Thermodynamic dissection of the binding energetics of KNI‐272, a potent HIV‐1 protease inhibitor [PDF]

, 2000
Adrián Velázquez‐Campoy, Irene Luque, Matthew J. Todd, Mark Milutinovich, Yoshiaki Kiso, Ernesto Freire   +5 more
openalex   +1 more source

Duration of Nucleos(t)ide Analogue Treatments in Patients With Chronic Hepatitis B Virus Infection in the United States

Journal of Viral Hepatitis, Volume 32, Issue 8, August 2025.
ABSTRACT Viral hepatitis caused by hepatitis B virus accounts for a significant disease burden. Nucleos(t)ide analogues (NAs) are the standard of care for chronic hepatitis B (CHB) infection; however, treatment is long‐term, and viral eradication resulting in cure is rare. Adherence to NAs is vital for disease control.
Seth Anderson, Vera Gielen, Anna D. Coutinho, Laura Clark, Christopher Bell, Shayon Salehi, Renee Gennarelli, Eileen Farrelly, Dana Stafkey, Robert Gish   +9 more
wiley   +1 more source

HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes. [PDF]

Biochem Biophys Res Commun, 2019
Schwake C, Baldwin MR, Bachovchin W, Hegde S, Schiemer J, Okure C, Levin AE, Vannier E, Hanada T, Chishti AH.   +9 more
europepmc   +1 more source

Trp42 rotamers report reduced flexibility when the inhibitor acetyl‐pepstatin is bound to HIV‐1 protease [PDF]

, 2000
Beáta Ullrich, Monique Laberge, F. Tölgyesi, Judit Fidy, Zoltán Szeltner, László Polgár   +5 more
openalex   +1 more source

NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
NKp30 is a crucial activating receptor on the surface of NK cells, mediating NK cell activation or the release of regulatory factors to exert cytotoxic effects by recognizing and binding to corresponding ligands. This article discusses the glycosylation of NKp30 and its pivotal role in antitumor and anti‐infection responses.
Yushu Shao, Yang Zhang, Jiaying Cao, Junyu He, Qian He, Yan Lei, Ning Tang, Yanhong Zhou   +7 more
wiley   +1 more source

Protease inhibitor-containing regimens compared with nucleoside analogues alone in the suppression of persistent HIV-1 replication in lymphoid tissue

, 1999
Lidia Ruíz, Jan van Lunzen, Albert Goday, Hans‐Jürgen Stellbrink, Claus M. Schneider, Miquel Rull, E. Castellà, Isabel Ojanguren, Douglas D. Richman, Bonaventura Clotet, Klara Tenner‐Racz, Paul Rácz   +11 more
openalex   +1 more source

Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
SARS‐CoV‐2 nsp13 is a promising target to develop effective antivirals. Pursuing the studies, new indolyl derivatives to deepen SARs are designed. The newly synthesized N‐aryl indoles are active vs both nsp13‐associated activities. They exert antiviral activity vs SARS‐CoV‐2 infected cells with no cytotoxicity.
Valentina Noemi Madia, Roberta Emmolo, Elisa Patacchini, Donatella Amatore, Stefania Maloccu, Davide Ialongo, Aurora Albano, Giuseppe Ruggieri, Emanuele Cara, Laura Zarbo, Antonella Messore, Riccardo De Santis, Alessandra Amoroso, Florigio Lista, Francesca Esposito, Enzo Tramontano, Angela Corona, Roberto Di Santo, Roberta Costi   +18 more
wiley   +1 more source

Phase I/II Study of the Toxicity, Pharmacokinetics, and Activity of the HIV Protease Inhibitor SC-52151

, 1997
Margaret A. Fischl, Douglas D. Richman, Charles Flexner, M F Para, Richard Haubrich, Aziz Karim, Patrick Yeramian, Jeanne Holden‐Wiltse, Patricia M. Meehan   +8 more
openalex   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, Volume 8, Issue 7, July 2025.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source