Results 251 to 260 of about 260,498 (362)

Clinical Safety and Tolerability of Bifidobacterium bifidum BBi32: An 8‐Week Randomized, Double‐Blind, Placebo‐Controlled Trial With Genomic and In Vitro Corroboration

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
An 8‐week randomized, double‐blind, placebo‐controlled trial found BBi32 well tolerated with no hematologic or hepatic abnormalities. Versus placebo, BBi32 reduced uric acid/urea/creatinine, increased LL‐37, and lowered gastrointestinal symptom scores.
Shuguang Fang, Shanni Wang, Yinhua Liu, Chengsheng Zhu, Sijia Wang, Fei Xu   +5 more
wiley   +1 more source

HIV protease inhibitors saquinavir and nelfinavir are potent inhibitors of cathepsin L activity: A potential treatment for COVID-19 patients

, 2020
Montenegro MF, Al-Abed Y, He M, Tracey KJ, Billiar TR.   +4 more
europepmc   +1 more source

Synthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals:  Stereocontrolled Synthetic Approach to the Key Mother Spiroketals

, 2001
Jia Yan, Bin Wu, Xin Li, Shi Kuo Ren, Yong Tu, Albert S. C. Chan, William Kitching   +6 more
openalex   +2 more sources

Efficacy, Effectiveness, and Safety of Treatment Regimens for Histoplasmosis and Tuberculosis Coinfection in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: A Systematic Review With Meta‐Analysis Protocol

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims While previous publications have briefly pointed out a few alternative therapeutic interventions for the treatment of histoplasmosis and tuberculosis coinfections in patients with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), there are no reviews evaluating the efficacy, effectiveness ...
Beatriz Bernava Sarinho, Inajara Rotta, Tácio de Mendonça Lima, Brígida Dias Fernandes, Patricia Melo Aguiar, Marília Berlofa Visacri   +5 more
wiley   +1 more source

Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors. [PDF]

Protein Sci, 2017
Clark KM, Jenkins JL, Fedoriw N, Dumont ME.   +3 more
europepmc   +1 more source

Development of a Next‐Generation Sequencing Protocol for Assessing Lenacapavir Resistance in HIV‐1 Capsid

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Lenacapavir (LEN) is a first‐in‐class capsid inhibitor (CAI) that targets multiple stages of the HIV‐1 lifecycle, showing efficacy in heavily treatment‐experienced (HTE) individuals with multidrug‐resistance (MDR) and in pre‐exposure prophylaxis (PrEP). This study aimed to characterize a novel in‐house next‐generation sequencing (NGS) protocol
Omar El Khalili, Collins Ambe Chenwi, Daniele Spalletta, Greta Marchegiani, Luca Carioti, Hossein Eizadi Moghadam, Ada Bertoli, Vincenzo Spagnuolo, Maria Mercedes Santoro, Francesca Ceccherini‐Silberstein, Maria Concetta Bellocchi   +10 more
wiley   +1 more source

Aminodiol HIV Protease Inhibitors. Synthesis And Structure−Activity Relationships Of P₁/P₁‘ Compounds:  Correlation between Lipophilicity and Cytotoxicity

, 1996
Ping Chen, Peter T. W. Cheng, Masud Alam, Barbara D. Beyer, Gregory S. Bisacchi, Tamara Dejneka, Adelaide J. Evans, Jill A. Greytok, Mark A. Hermsmeier, W. Griffith Humphreys, G. A. JACOBS, Octavian Kocy, Pin‐Fang Lin, Karen A. Lis, Michael A. Marella, Denis E. Ryono, Amy K. Sheaffer, Steven H. Spergel, Chong‐Qing Sun, Joseph A. Tino, Gregory D. Vite, Richard J. Colonno, Robert Zahler, Joel C. Barrish   +23 more
openalex   +1 more source

HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophages.

Journal of Clinical Investigation, 2003
James L Dressman, J. Kincer, S. Matveev, Ling Guo, R. Greenberg, T. Guerin, David Meade, Xiang-An Li, Weifei Zhu, Annette M. Uittenbogaard, M. Wilson, E. Smart   +11 more
semanticscholar   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo.

Cancer Research, 2005
Anjali K. Gupta, G. Cerniglia, R. Mick, W. McKenna, R. Muschel   +4 more
semanticscholar   +1 more source