Results 271 to 280 of about 260,498 (362)

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Highly Potent Phosphinic HIV‑1 Protease Inhibitors: Synthesis, In Vitro Evaluation, and Docking Studies. [PDF]

ACS Omega
Hayat K, Qiu D, Wang Y, Imbenzi PS, Khan FI, Matziari M.   +5 more
europepmc   +1 more source

Extracellular Vesicles Favor Early Peripheral Immunosenescence Through Modulation of the Senescence‐Associated Secretory Phenotype in HIV Infection

Aging Cell, Volume 25, Issue 1, January 2026.
The senescence‐associated secretory phenotype (SASP) is one of the main factors contributing to immunosenescence in chronic HIV infection. Extracellular vesicles (EVs) present in the plasma of chronically infected people living with HIV (PLWH) represent an important mechanism for inducing SASP, particularly IL‐6 expression in peripheral cells.
Ricardo Cardoso Castro, Humberto Doriguetto Gravina, Fabrícia Heloísa Cavicchioli Sugiyama, Yann Lamarre, Caroline Fontanari, Bonita Powell, Olesia Gololobova, Zhaohao Liao, Fausto Almeida, Simone Kashima, Kenneth Witwer, Fabiani Gai Frantz   +11 more
wiley   +1 more source

Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure

, 2018
Raza M. Alvi, Anne M. Neilan, Noor Tariq, Magid Awadalla, Maryam Afshar, Dahlia Banerji, Adam Rokicki, Connor P. Mulligan, Virginia A. Triant, Markella V. Zanni, Tomas G. Neilan   +10 more
openalex   +2 more sources

Systemic LINE‐1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS‐STING Pathway in Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Plasma extracellular vesicle‐derived LINE‐1 RNA increases with age and crosses the blood–brain barrier to activate microglial cGAS‐STING signaling, driving neuroinflammation and cognitive decline. Inhibition of LINE‐1 reverse transcription or STING signaling ameliorates these aging‐related deficits.
Shuyi Yu, Qian Cheng, Qian Yu, Zhikang Cui, Hang Chen, Shuang Wu, Yan Jin, Yunshan Wang, Ming Li, Zhiming Lu   +9 more
wiley   +1 more source

Designing Potent HIV‑1 Protease Inhibitors Using Machine Learning and QSAR Approaches. [PDF]

ACS Omega
Ali S, Dwi Putra I, Chuntakaruk H, Wolschann P, Maitarad P, Rungrotmongkol T, Hannongbua S.   +6 more
europepmc   +1 more source

Comparative Binding Energy Analysis of HIV-1 Protease Inhibitors:  Incorporation of Solvent Effects and Validation as a Powerful Tool in Receptor-Based Drug Design

, 1998
Carlos A. Perez, Manuel Pastor, Ángel R. Ortíz, Federico Gago   +3 more
openalex   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source

A Highly Sensitive BRET-Based Reporter for Live-Cell Detection of HIV-1 Protease Activity and Inhibitor Screening. [PDF]

Viruses
Centazzo M, Djossou AV, Pavan S, Alvisi G.   +3 more
europepmc   +1 more source

Design, Synthesis,and Biological Evaluation of NovelCore Scaffold-Modified HIV‑1 Protease Inhibitors for OvercomingDrug Resistance

Huiyu Zhou (535329), Yu Gao (69071), Qingqing Yang (1628146), Qi Shan (10516950), Sihan Meng (14507207), Ling Ma (107282), Biao Dong (519216), Juxian Wang (2039833), Guoning Zhang (7417700), Minghua Wang (37199), Shan Cen (107285), Yucheng Wang (154813), Yongsheng Che (131901), Mei Zhu (224674)   +13 more
openalex   +1 more source