Results 71 to 80 of about 73,667 (245)

Time to treatment disruption in children with HIV-1 randomized to initial antiretroviral therapy with protease inhibitors versus non-nucleoside reverse transcriptase inhibitors.

PLoS ONE, 2020
BackgroundChoice of initial antiretroviral therapy regimen may help children with HIV maintain optimal, continuous therapy. We assessed treatment-naïve children for differences in time to treatment disruption across randomly-assigned protease inhibitor ...
Dwight E Yin, Christina Ludema, Stephen R Cole, Carol E Golin, William C Miller, Meredith G Warshaw, Ross E McKinney, PENPACT-1 (PENTA 9 / PACTG 390) Study Team   +7 more
doaj   +1 more source

Association Between HIV Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross‐Sectional Study Using Cardiac MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Antiretroviral therapy has transformed HIV into a chronic condition, yet cardiac injury remains a major issue. Purpose To assess the ability of cardiac MR imaging markers to predict cardiac injury and disease progression in HIV‐infected individuals. Study Type Prospective.
Chunyan Deng, Wei Sun, Tianhu Gao, Haixia Chen, Lu Liu, Ran Li   +5 more
wiley   +1 more source

Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis [PDF]

, 2013
Includes bibliographical references.Sub-Saharan Africa is overwhelmed by dual epidemics of human immunodeficiency virus (HIV) and tuberculosis (TB) infection.
Cohen, Karen
core  

Designing Novel Hydrazinecarbothioamides as Potential HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Proceedings, 2017
Reverse transcriptase (RT), the key enzyme in the HIV life cycle of HIV, is one of the main targets for the antiretroviral chemotherapy. [...]
Hong Yin, Zhengyong Wan, Ge Meng, Fen-Er Chen, Erik De Clercq, and Christophe Pannecouque   +5 more
doaj   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Telomerase promoter mutations in human immunodeficiency virus-related conjunctiva neoplasia

Journal of Translational Medicine, 2018
Background Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection.
Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello   +3 more
doaj   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

Liquid Chromatography-Mass Spectrometry Metabolomic Analysis of Terminalia ferdinandiana Exell. Fruit Extracts That Inhibit HIV-1 Cell Infection, HIV-1 Reverse Transcriptase and HIV-1 Protease [PDF]

The emergence of HIV strains resistant to the current anti-retroviral drugs has necessitated the search for new anti-retroviral medications. Methanolic and aqueous T.
Cock, Ian Edwin, Matthews, Benjamin, Adriaan Erasmus Basson, Basson, Adriaan Erasmus, Ian Edwin Cock, Benjamin Matthews   +5 more
core   +2 more sources

HIV-1 Drug Resistance mutations against nucleotide reverse transcriptase inhibitors (NRTI), non-nucleotide reverse transcriptase inhibitors (NNRTI) and protease inhibitors (PI) identified by the ATCC assay versus the ViroSeq assay for those individual patients harbouring drug resistance mutations. [PDF]

, 2018
HIV-1 Drug Resistance mutations against nucleotide reverse transcriptase inhibitors (NRTI), non-nucleotide reverse transcriptase inhibitors (NNRTI) and protease inhibitors (PI) identified by the ATCC assay versus the ViroSeq assay for those individual ...
Okpokwu Jonathan (5464964), Imade Godwin (5465006), Okwuraiwe Azuka (5465009), DeVos Joshua (5464994), Ahmed Mukhtar (5464982), Musa Zaidat (5465015), Raizes Elliot (5464973), Onwuamah Chika (5464961), Agbaji Oche (5464988), Yang Chunfu (5464985), Idigbe Emmanuel (5465018), Odaibo Georgina (5464997), Chaplin Beth (5465003), Ezechi Oliver (5464976), Kanki Phyllis (5465000), Samuel Jay (5464967), Olaleye David (5464979), Audu Rosemary (5464970), Dalhatu Ibrahim (5465012), Chebu Philippe (5464991)   +19 more
core   +1 more source

Discovery of Biphenyl-Substituted Diarylpyrimidines as New Non-Nucleoside HIV-1 Reverse Transcripttase Inhibitors

Proceedings, 2017
Reverse transcriptase (RT), the key enzyme in the HIV life cycle of HIV, is one of the main targets for the antiretroviral chemotherapy. [...]
Kaijun Jin, Ge Meng, Fen-Er Chen, Erik De Clercq, Christophe Pannecouque   +4 more
doaj   +1 more source