Results 1 to 10 of about 4,701 (92)
Relationship between the Occurrence of Genetic Variants of Single Nucleotide Polymorphism in microRNA Processing Genes and the Risk of Developing Multiple Sclerosis [PDF]
Biomedicines, 2022 Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS), which leads to disturbances in the conduction of nerve impulses, cognitive impairment, sensory and motor disturbances, as well as depressive symptoms. MS
Justyna Basak +3 more
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MEIS1 promotes expression of stem cell markers in esophageal squamous cell carcinoma [PDF]
BMC Cancer, 2020 Background MEIS1 (Myeloid ecotropic viral integration site 1) as a homeobox (HOX) transcription factor plays regulatory roles in a variety of cellular processes including development, differentiation, survival, apoptosis and hematopoiesis, as well as ...
Selma Zargari +3 more
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Hiwi mediated tumorigenesis is associated with DNA hypermethylation. [PDF]
PLoS ONE, 2012 Expression of Piwi proteins is confined to early development and stem cells during which they suppress transposon migration via DNA methylation to ensure genomic stability. Piwi's genomic protective function conflicts with reports that its human ortholog,
Sara Siddiqi +2 more
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HTS Teologiese Studies/Theological Studies, 2021 The biblical story on the miracle of the manna in the Sinai Desert aroused many discussions and interpretations over the generations. The current study focuses on Ibn Ezra’s controversy with Hiwi al-Balkhi on the question of whether the manna was a ...
Abraham O. Shemesh
doaj +1 more source
Egyptian Journal of Medical Human Genetics, 2022 Background SALL4 and HIWI are involved in the maintenance of self-renewal capacity of stem cells. Several scrutinizes have demonstrated that SALL4 and HIWI play a key role in cancer development.
Mohammad Mahdi Forghanifard +1 more
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Piwi genes are dispensable for normal hematopoiesis in mice. [PDF]
PLoS ONE, 2013 Hematopoietic stem cells (HSC) must engage in a life-long balance between self-renewal and differentiation to sustain hematopoiesis. The highly conserved PIWI protein family regulates proliferative states of stem cells and their progeny in diverse ...
Mona J Nolde +3 more
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Frontiers in Cell and Developmental Biology, 2021 P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a class of small non-coding RNA molecules that are 24–31 nucleotides in length. PiRNAs are thought to bind to PIWI proteins (PIWL1-4, a subfamily of Argonaute proteins), forming piRNA ...
Peixin Dong +8 more
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Genetic variations in key microRNA processing genes and risk of head and neck cancer: a case-control study in Chinese population. [PDF]
PLoS ONE, 2012 MicroRNAs (miRNAs) have been reported to play a key role in oncogenesis. Genetic variations in miRNA processing genes and miRNA binding sites may affect the biogenesis of miRNA and the miRNA-mRNA interactions, hence promoting tumorigenesis.
Hongxia Ma +8 more
doaj +1 more source
BMC Cancer, 2009 Background HIWI, the human homologue of Piwi family, is present in CD34+ hematopoietic stem cells and germ cells, but not in well-differentiated cell populations, indicating that HIWI may play an impotent role in determining or maintaining stemness of ...
Shou Chengcao +8 more
doaj +1 more source
Supported bilayers: combined specular and diffuse x-ray scattering [PDF]
, 2009 A new method is proposed for the analysis of specular and off-specular reflectivity from supported lipid bilayers. Both thermal fluctuations and the "static" roughness induced by the substrate are carefully taken into account.
Charitat, Thierry +2 more
core +2 more sources