Results 21 to 30 of about 1,023 (128)

Reconstructing prehistoric demography: What role for extant hunter‐gatherers?

Evolutionary Anthropology: Issues, News, and Reviews, Volume 29, Issue 6, Page 332-345, November/December 2020., 2020
Abstract Demography is central to biological, behavioral, and cultural evolution. Knowledge of the demography of prehistoric populations of both Homo sapiens and earlier members of the genus Homo is, therefore, key to the study of human evolution.
Abigail E. Page, Jennifer C. French
wiley   +1 more source

Reversing Lanmodulin's Metal‐Binding Sequence in Short Peptides Surprisingly Increases the Lanthanide Affinity

Angewandte Chemie, Volume 137, Issue 46, November 10, 2025.
Accidentally reversing the lanthanide‐binding sequences of lanmodulin‐inspired short peptides lead to the serendipitous discovery of a set of peptides with a one order of magnitude higher lanthanide‐binding affinity than the uncapped peptides synthesised in the correct direction.
Sophie M. Gutenthaler‐Tietze, Jerome Kretzschmar, Satoru Tsushima, Robin Steudtner, Björn Drobot, Lena J. Daumann   +5 more
wiley   +2 more sources

Genetic disorders and male infertility

Reproductive Medicine and Biology, Volume 19, Issue 4, Page 314-322, October 2020., 2020
Abstract Background At present, one out of six couples is infertile, and in 50% of cases, infertility is attributed to male infertility factors. Genetic abnormalities are found in 10%‐20% of patients showing severe spermatogenesis disorders, including non‐obstructive azoospermia.
Shinnosuke Kuroda, Kimitsugu Usui, Hiroyuki Sanjo, Teppei Takeshima, Takashi Kawahara, Hiroji Uemura, Yasushi Yumura   +6 more
wiley   +1 more source

Epidemiological evidence for associations between variants in microRNA or biosynthesis genes and lung cancer risk

Cancer Medicine, Volume 9, Issue 5, Page 1937-1950, March 2020., 2020
Our study evaluated the cumulative evidence of significant associations between SNPs in miRNA or biosynthesis genes and lung cancer (LC) risk by combining Venice Criteria and false‐positive report probability test. Two variants with four associations were rated as demonstrating strong evidence with risk of LC, three associations were moderate, and ...
Guanchu Liu, Jie Tian, Chunjian Zuo, Yufu Li, Kui Fu, Huanwen Chen   +5 more
wiley   +1 more source

Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells

Cell Reports, 2012
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been shown to differentiate into primordial germ cells (PGCs) but not into spermatogonia, haploid spermatocytes, or spermatids.
Charles A. Easley, IV, Bart T. Phillips, Megan M. McGuire, Jennifer M. Barringer, Hanna Valli, Brian P. Hermann, Calvin R. Simerly, Aleksander Rajkovic, Toshio Miki, Kyle E. Orwig, Gerald P. Schatten   +10 more
doaj   +1 more source

Common genetic polymorphisms of microRNA biogenesis pathway genes and breast cancer survival

BMC Cancer, 2012
Background Although the role of microRNA’s (miRNA’s) biogenesis pathway genes in cancer development and progression has been well established, the association between genetic variants of this pathway genes and breast cancer survival is still unknown ...
Sung Hyuna, Jeon Sujee, Lee Kyoung-Mu, Han Sohee, Song Minkyo, Choi Ji-Yeob, Park Sue K, Yoo Keun-Young, Noh Dong-Young, Ahn Sei-Hyun, Kang Daehee   +10 more
doaj   +1 more source

HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection [PDF]

Cancer, 2011
AbstractBACKGROUND:PIWI protein family was found to play an important role in stem cell self‐renewal. Overexpression of HIWI, the human homolog of PIWI family proteins, was found in several solid tumors, although the role of HIWI in hepatocellular carcinoma (HCC) and its prognostic value remain unclear.METHODS:HIWI expression was measured in stepwise ...
Yi-Ming, Zhao, Jia-Min, Zhou, Long-Rong, Wang, Hong-Wei, He, Xi-Long, Wang, Zhong-Hua, Tao, Hui-Chuan, Sun, Wei-Zhong, Wu, Jia, Fan, Zhao-You, Tang, Lu, Wang   +10 more
openaire   +2 more sources

Silencing HIWI suppresses the growth, invasion and migration of glioma cells

International Journal of Oncology, 2014
The HIWI gene is one of the members of the PIWI gene family that is important for stem cell self‑renewal and expressed highly in certain human tumors. Some studies have demonstrated that HIWI plays a key role in the development of tumors in cervical, colon and liver cancer.
Xiuyu, Wang, Xiaoguang, Tong, Hongmei, Gao, Xiaoling, Yan, Xinnv, Xu, Shupeng, Sun, Qiong, Wang, Jinhuan, Wang   +7 more
openaire   +3 more sources

Overexpression of Argonaute HIWI Gene in Colorectal Cancer Stem Cells and Colorectal Cancerous Tissue [PDF]

, 2022
Abstract Background: Recent studies have shown that Hiwi has a crucial role in stem cell self-renewal in various organisms and it is also associated with some cancers. In the present study, Hiwi expression was examined in different grades of primary human colorectal cancer (CRC), colorectal cancer stem cells (CRCSCs) and HT-29 CRC cell line ...
Soheila Moeini, Eisa Tahmasbpour Marzouni, Asghar Beigi Harchegani, Mahdi Ghatrehsamani, Saeid Rahmanzadeh   +4 more
openaire   +1 more source

PIWIL1 suppresses circadian rhythms through GSK3β‐induced phosphorylation and degradation of CLOCK and BMAL1 in cancer cells

Journal of Cellular and Molecular Medicine, Volume 23, Issue 7, Page 4689-4698, July 2019., 2019
Abstract Circadian rhythms are maintained by series of circadian clock proteins, and post‐translation modifications of clock proteins significantly contribute to regulating circadian clock. However, the underlying upstream mechanism of circadian genes that are responsible for circadian rhythms in cancer cells remains unknown.
Hao Tan, Yingchuan Zhu, Xulei Zheng, Yilu Lu, Dachang Tao, Yunqiang Liu, Yongxin Ma   +6 more
wiley   +1 more source