Results 171 to 180 of about 141,660 (219)
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The Lancet, 1976
Histocompatibility antigens were determined in 38 patients with frozen shoulder and 216 normal blood-donors. HLA-B27 was significantly more common in patients with frozen shoulder (42%) than in the controls (10%). The distribution of the other 19 histocompatibility antigens was similar in the patient and control groups.
D Y, Bulgen, B L, Hazleman, D, Voak
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Histocompatibility antigens were determined in 38 patients with frozen shoulder and 216 normal blood-donors. HLA-B27 was significantly more common in patients with frozen shoulder (42%) than in the controls (10%). The distribution of the other 19 histocompatibility antigens was similar in the patient and control groups.
D Y, Bulgen, B L, Hazleman, D, Voak
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Neutrophil Function and HLA-B27
Rheumatology, 1983The pathogenesis of HLA-B27 linked diseases, including reactive enteroarthritides, is not known. Differences in immune response, cross-reaction between microbial antigens and host cell structures, attachment of microbial components on the host cell surfaces with subsequent autoimmune reaction, and inflammatory responsiveness of the host may be involved.
H, Repo +8 more
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Non-HLA-B27 Genetic Factors in HLA-B27 Associated Diseases
Clinical Rheumatology, 1996Family and twin studies showed that besides HLA-B27 other genetic factors are of significance for the pathogenesis of ankylosing spondylitis, reactive arthritis or acute anterior uveitis. There are up to now no strong indications that any subtype of B27 is especially associated with these diseases.
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HLA-B27 and the Seronegative Spondyloarthropathies
The American Journal of the Medical Sciences, 1998In the 25 years since the initial reports of the association of HLA-B27 with ankylosing spondylitis (AS) and subsequently with Reiter's syndrome, psoriatic spondylitis, and the spondylitis of inflammatory bowel disease, the association of HLA-B27 with the seronegative spondyloarthropathies has remained one of the best examples of a disease association ...
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HLA-B27 and pathogenesis of spondyloarthropathies
Current Opinion in Rheumatology, 2002Although the influence of HLA-B27 on the development of spondyloarthropathies is undisputed, its role in pathogenesis remains unclear. New ideas have focused on abnormal characteristics of HLA-B27 resulting from aberrant folding, disulfide bond formation, or both, rather than a predilection for selecting arthritogenic peptides.
Matthew J, Turner, Robert A, Colbert
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HLA-B27: To Type or Not to Type?
Annals of Internal Medicine, 1980The association between the histocompatibility antigen HLA-B27 and the seronegative spondylarthritides such as ankylosing spondylitis and Reiter's syndrome is dramatic. A question that arises in practice is, when should a clinician request HLA-B27 typing in the assessment of a patient with a rheumatologic complaint?
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HLA-B27 and immunogenetics of spondyloarthropathies
Current Opinion in Rheumatology, 2000The arthritogenic peptide hypothesis has inspired research aimed at defining the peptide-presenting properties of HLA-B27 subtypes and their relation to ankylosing spondylitis. Various studies have shed new light on the influence of HLA-B27 polymorphism in modulating peptide binding and T-cell antigen presentation.
I, Alvarez, J A, López de Castro
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Ophthalmology Clinics of North America, 2002
HLA-B27--associated acute anterior uveitis, a relatively common form of uveal inflammation, has a sufficiently characteristic presentation that the diagnosis is often suggested by clinical assessment, although testing for HLA-B27 status provides strong support for the diagnosis. This condition usually responds readily to topical corticosteroid therapy,
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HLA-B27--associated acute anterior uveitis, a relatively common form of uveal inflammation, has a sufficiently characteristic presentation that the diagnosis is often suggested by clinical assessment, although testing for HLA-B27 status provides strong support for the diagnosis. This condition usually responds readily to topical corticosteroid therapy,
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Immunogenetics, HLA-B27 and spondyloarthropathies
Current Opinion in Rheumatology, 1999HLA-B27 is the strongest HLA molecule associated with a disease. However, the reason only a small fraction of HLA-B27 positive individuals develop spondyloarthropathies is still unknown. Recent advances in genetics support the fact that additional genetic factors influence the disease and that the environmental factors may be ubiquitous.
S, González +2 more
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HLA-B27 Is Necessary But Not Sufficient
Scandinavian Journal of Rheumatology, 1990It is discussed why some, but not all HLA-B27-positive persons get disease when triggered by certain infections. The conclusions are that a possible modifying gene may be found on the other HLA haplotype or outside the HLA complex. Given an epidemic infection afflicting a family, it is the possible differences of other environmental factors which may ...
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