Results 171 to 180 of about 116,043 (221)

HLA‐B27 and the pathogenesis of spondyloarthritis

Tissue Antigens, 2002
Abstract: The association of HLA‐B27 with ankylosing spondylitis and other spondyloarthropathies ranks among the strongest between any HLA antigen and a human disease. Yet, in spite of intense research and advanced knowledge of the biochemistry and biology of major histocompatibility complex molecules, the mechanism of this association remains unknown.
M, Ramos, J A, López de Castro
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HLA-B27 AND FROZEN SHOULDER

The Lancet, 1976
Histocompatibility antigens were determined in 38 patients with frozen shoulder and 216 normal blood-donors. HLA-B27 was significantly more common in patients with frozen shoulder (42%) than in the controls (10%). The distribution of the other 19 histocompatibility antigens was similar in the patient and control groups.
D Y, Bulgen, B L, Hazleman, D, Voak
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Neutrophil Function and HLA-B27

Rheumatology, 1983
The pathogenesis of HLA-B27 linked diseases, including reactive enteroarthritides, is not known. Differences in immune response, cross-reaction between microbial antigens and host cell structures, attachment of microbial components on the host cell surfaces with subsequent autoimmune reaction, and inflammatory responsiveness of the host may be involved.
H, Repo, M, Leirisalo, P, Koivuranta, T, Osterman, U, Kiistala, C G, Gahmberg, H, Vapaatalo, A, Tiilikainen, O, Laitinen   +8 more
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Non-HLA-B27 Genetic Factors in HLA-B27 Associated Diseases

Clinical Rheumatology, 1996
Family and twin studies showed that besides HLA-B27 other genetic factors are of significance for the pathogenesis of ankylosing spondylitis, reactive arthritis or acute anterior uveitis. There are up to now no strong indications that any subtype of B27 is especially associated with these diseases.
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HLA-B27 and the Seronegative Spondyloarthropathies

The American Journal of the Medical Sciences, 1998
In the 25 years since the initial reports of the association of HLA-B27 with ankylosing spondylitis (AS) and subsequently with Reiter's syndrome, psoriatic spondylitis, and the spondylitis of inflammatory bowel disease, the association of HLA-B27 with the seronegative spondyloarthropathies has remained one of the best examples of a disease association ...
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HLA-B27 and immunogenetics of spondyloarthropathies

Current Opinion in Rheumatology, 2000
The arthritogenic peptide hypothesis has inspired research aimed at defining the peptide-presenting properties of HLA-B27 subtypes and their relation to ankylosing spondylitis. Various studies have shed new light on the influence of HLA-B27 polymorphism in modulating peptide binding and T-cell antigen presentation.
I, Alvarez, J A, López de Castro
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The Role of HLA-B27 in Spondyloarthritis

The Journal of Rheumatology, 2010
This article summarizes the proceedings of a one-day international workshop held in July 2009 on the role of HLA-B27 in the pathogenesis of ankylosing spondylitis (AS) and related disorders. HLA-B27 is found in about 90% of patients with AS, with an odds ratio of about 100, but the mechanism underlying this association is not known. There are currently
openaire   +2 more sources

Monoclonal Antibodies to HLA-B27

Rheumatology, 1983
Because HLA-B27 is such an important genetic marker for susceptibility to spondyloarthropathies and other related diseases, study of this alloantigen was undertaken using murine monoclonal antibodies. The first monoclonal anti-B27 antibody, B27M1, is an IgG2a lymphocytotoxic antibody that reacts with all B27 antigens and cross-reacts to a lesser degree
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Immunogenetics, HLA-B27 and spondyloarthropathies

Current Opinion in Rheumatology, 1999
HLA-B27 is the strongest HLA molecule associated with a disease. However, the reason only a small fraction of HLA-B27 positive individuals develop spondyloarthropathies is still unknown. Recent advances in genetics support the fact that additional genetic factors influence the disease and that the environmental factors may be ubiquitous.
S, González, J, Martínez-Borra, C, López-Larrea   +2 more
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HLA-B27 polymorphism in the Malays

Tissue Antigens, 2003
Abstract:  The frequency of HLA‐B27 and its subtypes was determined in 878 Malay subjects. Thirty‐five of the subjects typed for HLA‐A, ‐B and ‐DR were found to be positive for HLA‐B27. The frequency of this allele in the Malay population was found to be 3.99%.
J S, Dhaliwal, C L, Too, M, Lisut, Y Y, Lee, S, Murad   +4 more
exaly   +3 more sources