Results 31 to 40 of about 15,677 (158)

Correlation of Interleukin-17 and 23 Inflammatory Markers with Genetically Transmitted Spondyloarthritis Patients at a Tertiary Care Facility, South India

Journal of Pure and Applied Microbiology, 2023
Human leukocyte antigens (HLA) are genetically derived proteins in the major histocompatibility complex. They help distinguish “self” and “non-self” antigens and are essential in interacting with the immune cells inside the body.
T. Jayaprakash, K.V. Leela, Balamurali Venkatesan, Sujith Ravi, Om Lokesh Muthamilan   +4 more
doaj   +1 more source

Human leukocyte Antigen-B*27 allele subtype prevalence and disease association of ankylosing spondylitis among south indian population

Indian Journal of Rheumatology, 2018
Aim: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis mainly affecting articular and extraarticular structures. AS clinical manifestations also involve sacroiliac joints and spine. Genetic factors play a key role in AS susceptibility.
Vikram Haridas, Praveenkumar Shetty, M Nirmal Kumar, K C Vasanthakumar, Kiran Haridas, Vitthal Khode, Anil Bargale   +6 more
doaj   +1 more source

The Rate of Helicobacter pylori Seropositivity in a Group of Korean Patients with HLA-B27-Associated Acute Anterior Uveitis. [PDF]

PLoS ONE, 2015
To investigate an association between Helicobacter pylori seropositivity and HLA-B27-positive acute anterior uveitis (AAU) in Korean patients.Retrospective analysis was performed with data from 106 patients previously diagnosed with AAU without clinical ...
Jeong Hun Bae, Joon Mo Kim
doaj   +1 more source

Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis

Di-san junyi daxue xuebao, 2020
Objective To analyze the positivity of human leukocyte surface antigen-B27 (HLA-B27) in patients with suspected ankylosing spondylitis (AS) and their relatives in Chongqing to understand the gender-specific distribution of HLA-B27 genotypes in the ...
GAO Lenyu, WU Hong, YOU Qingxia, WANG Yong   +3 more
doaj   +1 more source

Microarray Analysis of Response of Salmonella during Infection of HLA-B27- Transfected Human Macrophage-Like U937 Cells

BMC Genomics, 2010
Background Human leukocyte antigen (HLA)-B27 is strongly associated with the development of reactive arthritis (ReA) in humans after salmonellosis. Human monocytic U937 cells transfected with HLA-B27 are less able to eliminate intracellular Salmonella ...
Hinton Jay CD, He Qiushui, Danino Vittoria, Ge Shichao, Granfors Kaisa   +4 more
doaj   +1 more source

Ultrasonographic assessment of enthesitis in HLA-B27 positive patients with rheumatoid arthritis, a matched case-only study. [PDF]

PLoS ONE, 2013
INTRODUCTION: HLA-B27 has a modifier effect on the phenotype of multiple diseases, both associated and non-associated with it. Among these effects, an increased frequency of clinical enthesitis in patients with Rheumatoid Arthritis (RA) has been reported
Antonio Mera-Varela, Aida Ferreiro-Iglesias, Eva Perez-Pampin, Marisol Porto-Silva, Juan J Gómez-Reino, Antonio Gonzalez   +5 more
doaj   +1 more source

Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients

Frontiers in Medicine, 2020
Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China.Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA ...
Shangzhu Zhang, Yanhong Wang, Linyi Peng, Jinmei Su, Xiaofeng Zeng, Mengtao Li, Zhenbiao Wu, Jian Xu, Min Yang, Lijun Wu, Cheng Zhao, Xinwang Duan, Qin Li, Jing Zhu, Wenqiang Fan   +14 more
doaj   +1 more source

The Frequency of HLA-B27 Antigen Positivity in Patients with Rheumatoid Arthritis and Anklylosing Spondylitis and The Relationship Between HLA-B27 Antigen and Other Autoantibodies

Hitit Medical Journal
Objective: The aim of this study was to research the frequency of Human Leukocyte Antigen (HLA)-B27 antigen positivity and relationship between HLA-B27 positivity and other autoantibodies and between HLA-B27 positivity and ...
Gülseren Demir Karakılıç, Esra Şahingöz Bakırcı, Ferda Büyük   +2 more
doaj   +1 more source

THE ASSOCIATION OF ERAP2 GENE POLYMORPHISMS WITH SERONEGATIVE SPONDYLOARTHROPATHIES IN HLA-B27 NEGATIVE ROMANIANS [PDF]

Romanian Journal of Rheumatology, 2016
Objective. Our aim was to investigate whether two ERAP2 single nucleotide polymorphisms (rs2910686 and rs2248374) influence spondyloarthritis (SpA) susceptibility in Romanians. Methods.
Laura Ioana Cherciu, Marius Cherciu, Luis Ovidiu Popa, Mihai Bojinca, Monica Irina Dutescu, Violeta Bojinca, Constantin Bara, Olivia Mihaela Popa   +7 more
doaj   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source