Results 31 to 40 of about 206,002 (249)

Human leukocyte antigen B polymorphism and association between HLA‐B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh

Rheumatology & Autoimmunity, 2022
Objectives To determine the association of Human leukocyte antigen B (HLA‑B) alleles with ankylosing spondylitis and the allelic association of HLA‐B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single‐nucleotide polymorphism (SNP) rs30187 in ...
Md Kamrul H. Sajib, Shamim Ahmed, Syed A. Haq, Minhaj R. Choudhury, Mohammed Uddin, Furkan Uddin, Muhammad S. A. Khan, Mohammad M. Zaman   +7 more
doaj   +1 more source

Correlation of Interleukin-17 and 23 Inflammatory Markers with Genetically Transmitted Spondyloarthritis Patients at a Tertiary Care Facility, South India

Journal of Pure and Applied Microbiology, 2023
Human leukocyte antigens (HLA) are genetically derived proteins in the major histocompatibility complex. They help distinguish “self” and “non-self” antigens and are essential in interacting with the immune cells inside the body.
T. Jayaprakash, K.V. Leela, Balamurali Venkatesan, Sujith Ravi, Om Lokesh Muthamilan   +4 more
doaj   +1 more source

Original paper HLA-B27 detection – comparison of genetic sequence-based method and flow cytometry assay

Rheumatology, 2015
Objectives : The presence of human leukocyte antigen B27 (HLA-B27) is strongly associated with ankylosing spondylitis. HLA-B27 testing is routinely applied in the diagnosis of this disease.
Urszula Skalska, Anna Kozakiewicz, Włodzimierz Maśliński, Monika Jurkowska   +3 more
doaj   +1 more source

The Rate of Helicobacter pylori Seropositivity in a Group of Korean Patients with HLA-B27-Associated Acute Anterior Uveitis. [PDF]

PLoS ONE, 2015
To investigate an association between Helicobacter pylori seropositivity and HLA-B27-positive acute anterior uveitis (AAU) in Korean patients.Retrospective analysis was performed with data from 106 patients previously diagnosed with AAU without clinical ...
Jeong Hun Bae, Joon Mo Kim
doaj   +1 more source

Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis

Di-san junyi daxue xuebao, 2020
Objective To analyze the positivity of human leukocyte surface antigen-B27 (HLA-B27) in patients with suspected ankylosing spondylitis (AS) and their relatives in Chongqing to understand the gender-specific distribution of HLA-B27 genotypes in the ...
GAO Lenyu, WU Hong, YOU Qingxia, WANG Yong   +3 more
doaj   +1 more source

Human leukocyte Antigen-B*27 allele subtype prevalence and disease association of ankylosing spondylitis among south indian population

Indian Journal of Rheumatology, 2018
Aim: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis mainly affecting articular and extraarticular structures. AS clinical manifestations also involve sacroiliac joints and spine. Genetic factors play a key role in AS susceptibility.
Vikram Haridas, Praveenkumar Shetty, M Nirmal Kumar, K C Vasanthakumar, Kiran Haridas, Vitthal Khode, Anil Bargale   +6 more
doaj   +1 more source

HLA-B27 Negativity Is Associated With Renal Function Decline in Patients With Ankylosing Spondylitis and Secondary IgA Nephropathy

Frontiers in Medicine, 2020
This study aimed to determine the impact of HLA-B27 on clinical phenotype and renal function during follow-up periods in patients with ankylosing spondylitis (AS) and secondary IgA nephropathy (IgAN). This single-center retrospective study included 71 AS
Ti Zhang, Fan Yang, Ke Zuo, Jinquan Wang, Zhen Cheng, Jiong Zhang   +5 more
doaj   +1 more source

HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis.

Journal of Clinical Investigation, 2019
Ankylosing spondylitis (AS) is a type of axial inflammation. Over time, some patients develop spinal ankylosis and permanent disability; however, current treatment strategies cannot arrest syndesmophyte formation completely.
Chin-Hsiu Liu, S. Raj, Chun-Hsiung Chen, Kuo-Hsuan Hung, C. Chou, I. Chen, J. Chien, I-Ying Lin, Shii-Yi Yang, T. Angata, W. Tsai, J. Wei, I. Tzeng, S. Hung, Kuo-I Lin   +14 more
semanticscholar   +1 more source

Role of HLA-B27 in the pathogenesis of ankylosing spondylitis

Molecular Medicine Reports, 2017
The study of ankylosing spondylitis (AS) has made significant progress over the last decade. Genome-wide association studies have identified and further substantiated the role of susceptibility genes outside the major histocompatibility complex locus ...
Bin Chen, Jia Li, Chong-ru He, Dahe Li, W. Tong, Yuming Zou, Weidong Xu   +6 more
semanticscholar   +1 more source

Is a positive family history of spondyloarthritis relevant for diagnosing axial spondyloarthritis once HLA-B27 status is known?

Rheumatology, 2019
Objectives A positive family history (PFH) of spondyloarthritis, in particular a PFH of AS or acute anterior uveitis, is associated with HLA-B27 carriership in chronic back pain patients.
M. van Lunteren, D. M. van der Heijde, A. Sepriano, I. Berg, M. Dougados, L. Gossec, L. Jacobsson, R. Ramonda, M. Rudwaleit, J. Sieper, R. Landewé, F. V. van Gaalen   +11 more
semanticscholar   +1 more source