Results 41 to 50 of about 206,002 (249)
The role of HLA-B27 in spondyloarthritis
Immunogenetics, 1999 The human major histocompatibility complex (MHC) class I allele HLA-B27 bears a striking association with the spondylolarthritic group of inflammatory arthritides, yet despite extensive studies its role in the disease process remains obscure. As an MHC class I protein, the primary function of HLA-B27 is to complex with beta(2)-microglobulin forming a ...
Allen, R, Bowness, P, McMichael, A
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Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?
Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 2018 The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine.
Amal Akassou, Y. Bakri
semanticscholar +1 more source
Ultrasonographic assessment of enthesitis in HLA-B27 positive patients with rheumatoid arthritis, a matched case-only study. [PDF]
PLoS ONE, 2013 INTRODUCTION: HLA-B27 has a modifier effect on the phenotype of multiple diseases, both associated and non-associated with it. Among these effects, an increased frequency of clinical enthesitis in patients with Rheumatoid Arthritis (RA) has been reported
Antonio Mera-Varela +5 more
doaj +1 more source
BMC Genomics, 2010 Background Human leukocyte antigen (HLA)-B27 is strongly associated with the development of reactive arthritis (ReA) in humans after salmonellosis. Human monocytic U937 cells transfected with HLA-B27 are less able to eliminate intracellular Salmonella ...
Hinton Jay CD +4 more
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Clinical Spectrum of HLA-B27-associated Ocular Inflammation
Ocular immunology and inflammation, 2017 Human leukocyte antigen (HLA)-B27-associated anterior uveitis (AU) is the most commonly diagnosed form of AU and represents the largest entity of non-infectious uveitis around the world.
K. Pathanapitoon +3 more
semanticscholar +1 more source
Annual Review of Immunology, 2015 Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown. Two broad theories most likely explain the role of HLA-B27 in AS pathogenesis. The first is based on the natural immunological function of HLA-B27 of presenting antigenic peptides ...
openaire +2 more sources
Annals of the Rheumatic Diseases, 2019 Objectives The human leucocyte antigen (HLA)-B27 confers an increased risk of spondyloarthritis (SpA) by unknown mechanism. The objective of this work was to uncover HLA-B27 non-canonical properties that could explain its pathogenicity, using a new ...
Benjamin Grandon +11 more
semanticscholar +1 more source
Hitit Medical JournalObjective: The aim of this study was to research the frequency of Human Leukocyte Antigen (HLA)-B27 antigen positivity and relationship between HLA-B27 positivity and other autoantibodies and between HLA-B27 positivity and ...
Gülseren Demir Karakılıç +2 more
doaj +1 more source
THE ASSOCIATION OF ERAP2 GENE POLYMORPHISMS WITH SERONEGATIVE SPONDYLOARTHROPATHIES IN HLA-B27 NEGATIVE ROMANIANS [PDF]
Romanian Journal of Rheumatology, 2016 Objective. Our aim was to investigate whether two ERAP2 single nucleotide polymorphisms (rs2910686 and rs2248374) influence spondyloarthritis (SpA) susceptibility in Romanians. Methods.
Laura Ioana Cherciu +7 more
doaj +1 more source
Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication
Annals of the Rheumatic Diseases, 2018 Objective Salmonella enterica infections can lead to Reactive Arthritis (ReA), which can exhibit an association with human leucocyte antigen (HLA)-B*27:05, a molecule prone to misfolding and initiation of the unfolded protein response (UPR).
A. Antoniou +12 more
semanticscholar +1 more source