Results 61 to 70 of about 206,002 (249)

Autoantibody response towards chromatin in patients with juvenile idiopathic arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Juvenile idiopathic arthritis (JIA) patients frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in JIA patients remains elusive. Methods Plasma samples from 110 untreated patients with active JIA, as well as from 14 children with ...
Viola Pitkänen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Anna‐Mari Schroderus, Liisa Kröger, Tuure Kinnunen   +13 more
wiley   +1 more source

The Associations of rs1799724 and rs361525 With the Risk of Ankylosing Spondylitis Are Dependent on HLA-B27 Status in a Chinese Han Population

Frontiers in Immunology, 2022
ObjectivesHuman leucocyte antigen B27 (HLA-B27) is an important biomarker for ankylosing spondylitis (AS). However, delay in the diagnosis of AS is still common in clinical practice.
Nan Sheng, Nan Sheng, Nan Sheng, Yingying Gao, Hui Li, Wenwen Wang, Linyu Geng, Bo Zhang, Qiang Huang, Xueqin Wang, Lingyun Sun   +10 more
doaj   +1 more source

Late‐Onset Spondylarthritis Presenting as Glucocorticoid‐Resistant Polymyalgia Rheumatica: A hitherto underappreciated entity where TNF or IL‐17 Blockade may have a Therapeutic Role

Arthritis &Rheumatology, Accepted Article.
Background Polymyalgia rheumatica (PMR) is an age‐related inflammatory disease with shoulder‐hip girdle involvement. Magnetic resonance imaging (MRI) reveals extracapsular/entheseal soft tissue involvements in both PMR and spondyloarthritis (SpA) with sacroiliac joint and peri‐entheseal spinal bone marrow oedema (BMO) being characteristic of SpA ...
Kerem Abacar, Gabriele De Marco, Jake Weddell, Katya Meridor, Tom Macleod, Andrew Scarsbrook, Kulveer Mankia, Edward Vital, Andrew Barr, Colin Pease, Helena Marzo‐Ortega, Sarah L. Mackie, Dennis McGonagle   +12 more
wiley   +1 more source

Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker

Kurdistan Journal of Applied Research
Rheumatoid arthritis (RA) is a predominant inflammatory arthritis in human. The function of HLA-B27 gene in other types of arthritis has been studied, however, its function in RA is unclear. This study investigated the relative expression of HLA-B27 gene
Karzan Ghafur Khidhir, Baban Ahmad, Dana Khdr Sabir   +2 more
doaj   +1 more source

HLA-B27 modulates intracellular growth of Salmonella pathogenicity island 2 mutants and production of cytokines in infected monocytic U937 cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Salmonella enterica serovar Enteritidis PT4 KS8822/88 replicates rapidly in HLA-B27-transfected human monocytic U937 cells. In this process, Salmonella pathogenicity island 2 (SPI-2) genes play a crucial role.
Shichao Ge, Qiushui He, Kaisa Granfors
doaj   +1 more source

Mutations in GFAP Alter Early Lineage Commitment of Organoids

Glia, EarlyView.
Mutations in GFAP alter lineage commitment of organoids. The severity of this commitment defect is dependent on the method of embryoid body formation. GFAP is expressed in iPSCs and during early stages of organoid development. Graphical abstract was created with BioRender.com .
Werner Dykstra, Zuzana Matusova, Rachel A. Battaglia, Pavel Abaffy, Nuria Goya‐Iglesias, Dolores Pérez‐Sala, Henrik Ahlenius, Mikael Kubista, R. Jeroen Pasterkamp, Li Li, Jianfei Chao, Yanhong Shi, Lukas Valihrach, Milos Pekny, Elly M. Hol   +14 more
wiley   +1 more source

Clinical features of HLA-B27-positive acute anterior uveitis with or without ankylosing spondylitis in a Chinese cohort

British Journal of Ophthalmology, 2017
Aims To characterise the clinical features of human leucocyte antigen (HLA)-B27+acute anterior uveitis (AAU) patients with or without ankylosing spondylitis (AS) and investigate the retinal vascular involvement in these patients.
Peizeng Yang, Wenjuan Wan, L. Du, Qingyun Zhou, Jian-Yan Qi, L. Liang, Chaokui Wang, Lili Wu, A. Kijlstra   +8 more
semanticscholar   +1 more source

The anti‐aging Klotho protects glioblastoma macrophages from radiotherapy‐induced inflammation and predicts immunotherapy response

International Journal of Cancer, EarlyView.
What's New? The anti‐aging protein klotho (KL) is a potential tumor suppressor and prognostic marker in glioblastoma. Little is known, however, about its mechanism of action and clinical relevance. This study examined KL expression in the setting of persistent inflammation and other stressors, including radiotherapy.
Andrea Galluzzo, Martina Maffezzini, Maria Luisa Fumagalli, Irene Sambruni, Silvia Musio, Monica Patanè, Rosina Paterra, Erika Salvi, Manuel Facciolla, Micaela Milani, Marco Schiariti, Luca Mattei, Alessandra Rossi, Marica Eoli, Luigi Poliani, Antonio Silvani, Bianca Pollo, Laura Fariselli, Natalia Di Ianni, Serena Pellegatta   +19 more
wiley   +1 more source

CHOP-mediated IL-23 overexpression does not drive colitis in experimental spondyloarthritis

Scientific Reports
HLA-B27 is a major risk factor for spondyloarthritis (SpA), yet the underlying mechanisms remain unclear. HLA-B27 misfolding-induced IL-23, which is mediated by endoplasmic reticulum (ER) stress has been hypothesized to drive SpA pathogenesis. Expression
Fatemeh Navid, Tejpal Gill, Lilah Fones, Jules D. Allbritton-King, Kelly Zhou, Isabel Shen, Jinny Van Doorn, Francesca LiCausi, Antony Cougnoux, Davide Randazzo, Stephen R. Brooks, Robert A. Colbert   +11 more
doaj   +1 more source

Association of Tralokinumab and Adalimumab: Good Tolerance and Efficacy in a Case of Severe Atopic Dermatitis and Juvenile Idiopathic Arthritis

JEADV Clinical Practice, EarlyView.
ABSTRACT Atopic dermatitis is a chronic inflammatory and pruritic skin disease. The combination of tralokinumab with adalimumab in the treatment of inflammatory diseases had not yet been documented. It appears promising for treating severe atopic dermatitis in patients with juvenile idiopathic arthritis, offering significant improvement in skin ...
F. Rakotonandrasana, E. Puzenat, A. Ducournau, D. Popescu   +3 more
wiley   +1 more source