Results 71 to 80 of about 206,002 (249)
Journal of Pure and Applied Microbiology, 2022 Human leukocyte antigens (HLA) are gene products found in the major histocompatibility complex, aiding in differentiation of “self” from “non-self” antigens, and is crucial for the communication between immune cells of the human body.
T. Jayaprakash +5 more
doaj +1 more source
Exploring the Cutaneous Associations of Crohn's Disease: A Retrospective Study of 108 Patients
JEADV Clinical Practice, EarlyView.ABSTRACT Background The integumentary system provides a window into the overall health of individuals and may display cutaneous manifestations of systemic disease. Crohn's Disease (CD) is a relapsing inflammatory bowel disease that exhibits a significant symptomatic burden on a global scale.
Max E. Oscherwitz +4 more
wiley +1 more source
Progression and topographic subtypes of Terrien marginal degeneration
Acta Ophthalmologica, EarlyView.Abstract Purpose To report long‐term outcomes and to search for immunological and genetic risk factors in Terrien marginal degeneration (TMD). Methods Retrospective, in part prospective, hospital‐based longitudinal follow‐up study of 32 eyes of 16 Finnish patients from 2012 to 2023. Median follow‐up was 7.3 years (range, 0.3–15.2).
Minna Ruutila +8 more
wiley +1 more source
Molecular & Cellular Proteomics, 2017 HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding
Eilon Barnea +10 more
semanticscholar +1 more source
Original paper Prevalence of HLA-B27 antigen in patients with juvenile idiopathic arthritis
Rheumatology, 2015 Introduction: Human leukocyte antigen B27 (HLA-B27) is considered as a risk factor for development of juvenile idiopathic arthritis (JIA). The aim of this study was to analyse the prevalence of HLA-B27 antigen in JIA categories and its influence on ...
Zbigniew Żuber +3 more
doaj +1 more source
Pediatric Dermatology, EarlyView.ABSTRACT Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive heterotopic ossification (HO) and congenital malformation of the great toes. This case describes a 5‐year‐old Caucasian girl who initially presented with painless neck and back swelling as well as severe limitation of movement in the neck and ...
Orhan Yilmaz, Loretta Fiorillo
wiley +1 more source
PLoS ONE, 2015 ObjectivesHLA-B27 is a common genetic risk factor for the development of Spondyloarthritides (SpA). HLA-B27 can misfold to form cell-surface heavy chain homodimers (B272) and induce pro-inflammatory responses that may lead to SpA pathogenesis.
Osiris Marroquin Belaunzaran +14 more
doaj +1 more source
Journal of Ophthalmology, 2020 Purpose. To report on patients who needed hospitalization due to acute anterior uveitis (AAU) and within this group to compare clinical features and outcomes of treatment of HLA-B27+ and HLA-B27− AAU in the population of Slovenian patients.
Katarina Vergot +3 more
doaj +1 more source
Acta Ophthalmologica, Volume 103, Issue 6, Page 684-690, September 2025.Abstract Purpose Uveitis‐associated macular edema (UME) is a significant cause of visual impairment in non‐infectious uveitis (NIU). However, the UME incidence remains unclear. Here, we evaluated the cumulative incidence of UME. Methods Medical records of patients registered with a uveitis diagnosis code between 2010 and2024 were assessed to validate ...
Bawan Halgurd +10 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 13, Issue 8, August 2025.B3GNT2, GPR35, and PSMG1genes are related to ankylosing spondylitis in the Chinese Han population. ABSTRACT Background Latest research on ankylosing spondylitis (AS) indicates a link between the B3GNT2, PSMG1 genes and susceptibility to AS among western populations.
Zijian Lian +8 more
wiley +1 more source