Original paper Prevalence of HLA-B27 antigen in patients with juvenile idiopathic arthritis [PDF]
Rheumatology, 2015 Introduction: Human leukocyte antigen B27 (HLA-B27) is considered as a risk factor for development of juvenile idiopathic arthritis (JIA). The aim of this study was to analyse the prevalence of HLA-B27 antigen in JIA categories and its influence on ...
Zbigniew Żuber +3 more
doaj +8 more sources
HLA B27 antigen in Middle Eastern and Arab countries: systematic review of the strength of association with axial spondyloarthritis and methodological gaps [PDF]
BMC Musculoskeletal Disorders, 2017 Background Axial spondyloarthritis (AxSpA) is a relatively frequent and debilitating disease, with a prevalence ranging from 0.1 to 2% in the Caucasian population.
Nelly Raymond Ziade
doaj +3 more sources
The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion * [PDF]
Molecular & Cellular Proteomics, 2017 HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding
Eilon Barnea +10 more
semanticscholar +4 more sources
Human leukocyte antigen B polymorphism and association between HLA‐B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh [PDF]
Rheumatology & Autoimmunity, 2022 Objectives To determine the association of Human leukocyte antigen B (HLA‑B) alleles with ankylosing spondylitis and the allelic association of HLA‐B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single‐nucleotide polymorphism (SNP) rs30187 in ...
Md Kamrul H. Sajib +7 more
doaj +2 more sources
Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis
RMD Open, 2023 The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility.
Joachim Sieper, Juergen Braun
doaj +2 more sources
Expanding the Genetic Framework: Insights into Non-HLA-B27 Contributions to Axial Spondylarthritis [PDF]
MedicinaBackground and Objectives: Spondylarthritis is a complex group of inflammatory diseases closely associated with the HLA-B27 antigen. However, the role of non-HLA-B27 alleles in the disease’s pathogenesis has gained significant scholarly attention in ...
Ruxandra-Elena Nagit +5 more
doaj +2 more sources
Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B27 [PDF]
, 2005 Spondyloarthropathies are inflammatory diseases closely associated with human leukocyte antigen (HLA)-B27 by unknown mechanisms. One of these diseases is reactive arthritis (ReA), which is typically triggered by Gram-negative bacteria, which have ...
Granfors, Kaisa +2 more
core +4 more sources
Bangladesh Medical Research Council Bulletin, 2015 Human leukocyte antigen B27 (HLA-B27), a class I molecules of the major histocompatibility complex has a strong disease association with different types of spondarthropathies (SpA).
A. Nessa, S. Tabassum, S. Sultana
semanticscholar +3 more sources
CD28 and CTLA4 polymorphisms associated with ankylosing spondylitis: a study in the context of HLA-B27 [PDF]
BMC ImmunologyBackground The human leukocyte antigen (HLA)-B27 gene is highly associated with ankylosing spondylitis (AS). However, not everyone who carries the HLA-B27 antigen develops AS, indicating that factors beyond the HLA-B27 gene contribute to the disease’s ...
Kuang-Hui Yu +5 more
doaj +2 more sources
Predictive values of inflammatory back pain, positive HLA B27 antigen and acute and chronic magnetic resonance changes in early diagnosis of Spondyloarthritis. A study of 133 patients. [PDF]
PLoS One, 2020 Komsalova LY +2 more
europepmc +3 more sources