Sponyloarthritis features forecasting the presence of HLA-B27 or sacroiliitis on magnetic resonance imaging in patients with suspected axial spondyloarthritis: Results from a cross-sectional study in the ESPeranza Cohort [PDF]
, 2015 Introduction: Chronic back pain (CBP) is frequently the presenting symptom in patients with suspected axial spondyloarthritis (axSpA). Presence of sacroiliitis on magnetic-resonance-imaging (MRI) or HLA-B27 adds to diagnostic certainty.
Almodóvar, Raquel +7 more
core +8 more sources
Human Leukocyte Antigen-B27 and Disease Susceptibility in Vojvodina, Serbia
Balkan Journal of Medical Genetics, 2012 There are numerous studies showing the role of human leukocyte antigens (HLAs) related with susceptibility or resistance to certain diseases.
Vojvodić S. +2 more
doaj +1 more source
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells [PDF]
, 2017 Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Abdelaal, Rawan +13 more
core +3 more sources
Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition
Immunology, Volume 175, Issue 3, Page 300-322, July 2025.Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen +14 more
wiley +1 more source
Identification of HLA‐B27–restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigen [PDF]
International Journal of Cancer, 2001 AbstractCharacterization of epitopes recognized by cytotoxic T lymphocytes (CTLs) in the sequence of tumor antigens is an important step in the development of tumor therapies. Because carcinoembryonic antigen (CEA) is a protein expressed in a high number of epithelial tumors, it is an interesting target to study. We screened for the presence of HLA‐B27–
Borras-Cuesta, F. (Francisco) +6 more
openaire +4 more sources
Determination of HLA-B27 Subtypes in Iranian Patients with Ankylosing Spondylitis
Iranian Journal of Allergy, Asthma and Immunology, 2008 The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS).
Mohamad Hossein Nicknam +10 more
doaj
Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication
Annals of the Rheumatic Diseases, 2018 Objective Salmonella enterica infections can lead to Reactive Arthritis (ReA), which can exhibit an association with human leucocyte antigen (HLA)-B*27:05, a molecule prone to misfolding and initiation of the unfolded protein response (UPR).
A. Antoniou +12 more
semanticscholar +1 more source
MedCommAcute anterior uveitis (AAU) is a common extra‐articular manifestation of ankylosing spondylitis (AS), particularly in patients positive for the human leucocyte antigen (HLA)‐B27 genetic marker.
Huan Li +16 more
doaj +1 more source
Mediators of Inflammation, 2017 Ankylosing spondylitis (AS) is highly associated with the expression of human leukocyte antigen-B27 (HLA-B∗27). HLA-B∗27 heavy chain (B27-HC) has an intrinsic propensity to fold slowly, leading to the accumulation of the misfolded B27-HC in the ...
Hui-Chun Yu +6 more
doaj +1 more source
A Review of Ankylosing Spondylitis [PDF]
, 2017 Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
core +1 more source