Results 21 to 30 of about 12,194 (179)

Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population. [PDF]

PLoS ONE, 2015
Ankylosing spondylitis (AS) is a form of chronic inflammatory spondyloarthritis (SpA) that causes pain and stiffness in spines or joints. Human leukocyte antigen B27 (HLA-B27) and B60 (HLA-B60) have been reported as major genetic risk factors of AS.
James Cheng-Chung Wei, Henry Wong Sung-Ching, Yu-Wen Hsu, Ya-Feng Wen, Wen-Chang Wang, Ruey-Hong Wong, Hsing-Fang Lu, Floris A van Gaalen, Wei-Chiao Chang   +8 more
doaj   +1 more source

Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis

RMD Open, 2023
The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility.
Joachim Sieper, Juergen Braun
doaj   +1 more source

HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation. [PDF]

Gut Microbes
Ankylosing spondylitis (AS) is strongly associated with the human leukocyte antigen B27 (HLA-B27), yet how this genetic risk factor interacts with the gut microbiome remains unclear.
Huang T, Yang H, Zhang L, Wang X, Chen Y, Dai H, Hashimoto K, Luo Y, Pu Y, Liu Y.   +9 more
europepmc   +2 more sources

Human leukocyte Antigen-B*27 allele subtype prevalence and disease association of ankylosing spondylitis among south indian population

Indian Journal of Rheumatology, 2018
Aim: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis mainly affecting articular and extraarticular structures. AS clinical manifestations also involve sacroiliac joints and spine. Genetic factors play a key role in AS susceptibility.
Vikram Haridas, Praveenkumar Shetty, M Nirmal Kumar, K C Vasanthakumar, Kiran Haridas, Vitthal Khode, Anil Bargale   +6 more
doaj   +1 more source

Human leukocyte antigen B polymorphism and association between HLA‐B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh

Rheumatology & Autoimmunity, 2022
Objectives To determine the association of Human leukocyte antigen B (HLA‑B) alleles with ankylosing spondylitis and the allelic association of HLA‐B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single‐nucleotide polymorphism (SNP) rs30187 in ...
Md Kamrul H. Sajib, Shamim Ahmed, Syed A. Haq, Minhaj R. Choudhury, Mohammed Uddin, Furkan Uddin, Muhammad S. A. Khan, Mohammad M. Zaman   +7 more
doaj   +1 more source

Clinical Features of Acute Anterior Uveitis with Complicated Course in a Slovenian Patient Population

Journal of Ophthalmology, 2020
Purpose. To report on patients who needed hospitalization due to acute anterior uveitis (AAU) and within this group to compare clinical features and outcomes of treatment of HLA-B27+ and HLA-B27− AAU in the population of Slovenian patients.
Katarina Vergot, Sasa Pockar, Lan Umek, Natasa Vidovic Valentincic   +3 more
doaj   +1 more source

Treatment Responses in Patients With Psoriatic Arthritis Axial Disease According to Human Leukocyte Antigen‐B27 Status: An Analysis From the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry

ACR Open Rheumatology, 2022
Objective Axial disease is common and burdensome in patients with psoriatic arthritis (PsA). Human leukocyte antigen‐B27 (HLA‐B27) is a risk factor for axial PsA; treatment response by HLA‐B27 status is inadequately characterized.
Philip J. Mease, Soumya D. Chakravarty, Robert R. McLean, Taylor Blachley, Toana Kawashima, Iris Lin, Arthur Kavanaugh, Alexis Ogdie   +7 more
doaj   +1 more source

Human Leukocyte Antigen B27‐Negative Axial Spondyloarthritis: What Do We Know?

ACR Open Rheumatology, 2023
Axial spondyloarthritis (axSpA) is a chronic, immune‐mediated disease characterized by inflammatory axial skeleton involvement and extra‐musculoskeletal manifestations.
Atul Deodhar, Tejpal Gill, Marina Magrey
doaj   +1 more source

Original paper HLA-B27 detection – comparison of genetic sequence-based method and flow cytometry assay

Rheumatology, 2015
Objectives : The presence of human leukocyte antigen B27 (HLA-B27) is strongly associated with ankylosing spondylitis. HLA-B27 testing is routinely applied in the diagnosis of this disease.
Urszula Skalska, Anna Kozakiewicz, Włodzimierz Maśliński, Monika Jurkowska   +3 more
doaj   +1 more source

HLA-B27 modulates intracellular growth of Salmonella pathogenicity island 2 mutants and production of cytokines in infected monocytic U937 cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Salmonella enterica serovar Enteritidis PT4 KS8822/88 replicates rapidly in HLA-B27-transfected human monocytic U937 cells. In this process, Salmonella pathogenicity island 2 (SPI-2) genes play a crucial role.
Shichao Ge, Qiushui He, Kaisa Granfors
doaj   +1 more source