Results 21 to 30 of about 12,247 (203)
Journal of Ophthalmology, 2020 Purpose. To report on patients who needed hospitalization due to acute anterior uveitis (AAU) and within this group to compare clinical features and outcomes of treatment of HLA-B27+ and HLA-B27− AAU in the population of Slovenian patients.
Katarina Vergot +3 more
doaj +1 more source
ACR Open Rheumatology, 2022 Objective Axial disease is common and burdensome in patients with psoriatic arthritis (PsA). Human leukocyte antigen‐B27 (HLA‐B27) is a risk factor for axial PsA; treatment response by HLA‐B27 status is inadequately characterized.
Philip J. Mease +7 more
doaj +1 more source
Human Leukocyte Antigen B27‐Negative Axial Spondyloarthritis: What Do We Know?
ACR Open Rheumatology, 2023 Axial spondyloarthritis (axSpA) is a chronic, immune‐mediated disease characterized by inflammatory axial skeleton involvement and extra‐musculoskeletal manifestations.
Atul Deodhar, Tejpal Gill, Marina Magrey
doaj +1 more source
Hla‐c locus antigens in hla‐b27 associated arthritis [PDF]
Arthritis & Rheumatism, 1978 AbstractFrequecies of the HLA‐C locus antigens, Cw 1, Cw2, Cw3, and Cw4, were determined in 88 patients with spondylitic diseases and 88 matched and 64 B27‐positive normal controls. Both Cw1 and Cw2 were significantly increased in B27‐positive patients and B27‐positive controls as compared to B27‐negative patients and matched controls.
F C, Arnett, M C, Hochberg, W B, Bias
openaire +2 more sources
Rheumatology, 2015 Objectives : The presence of human leukocyte antigen B27 (HLA-B27) is strongly associated with ankylosing spondylitis. HLA-B27 testing is routinely applied in the diagnosis of this disease.
Urszula Skalska +3 more
doaj +1 more source
Exhaustion-Resistant CD8 <sup>+</sup> T Cells in Ankylosing Spondylitis: A Proposed Three-Axis Model. [PDF]
ImmunologyExhaustion‐resistant CD8+ T cells may sustain ankylosing spondylitis. A three‐axis model—intermittent T‐cell receptor engagement, IL‐15/CD28 co‐stimulation and maintained metabolic fitness—explains how PD‐1^high CD8+ T cells retain effector function and accumulate from gut to entheses, promoting inflammation and aberrant bone remodelling.
Zhang X, Jia L, Lin X, Zhou L.
europepmc +2 more sources
Romanian Journal of Laboratory Medicine, 2023 To explore the changes in C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), human leukocyte antigen-B27 (HLA-B27), and immunoglobulin (Ig) (IgA, IgG, and IgM) in patients suffering from ankylosing spondylitis (AS).
Zhu Lixiu +5 more
doaj +1 more source
HLA-B27 modulates intracellular growth of Salmonella pathogenicity island 2 mutants and production of cytokines in infected monocytic U937 cells. [PDF]
PLoS ONE, 2012 BACKGROUND: Salmonella enterica serovar Enteritidis PT4 KS8822/88 replicates rapidly in HLA-B27-transfected human monocytic U937 cells. In this process, Salmonella pathogenicity island 2 (SPI-2) genes play a crucial role.
Shichao Ge, Qiushui He, Kaisa Granfors
doaj +1 more source
Frontiers in Immunology, 2022 ObjectivesHuman leucocyte antigen B27 (HLA-B27) is an important biomarker for ankylosing spondylitis (AS). However, delay in the diagnosis of AS is still common in clinical practice.
Nan Sheng +10 more
doaj +1 more source
Phosphorylation of STAT-1 serine 727 is prolonged in HLA-B27-expressing human monocytic cells. [PDF]
PLoS ONE, 2013 A tissue antigen, HLA-B27, is strongly associated with a group of rheumatic diseases called spondyloarthritides. Despite the intensive research, the exact role of HLA-B27 in the pathogenesis of these diseases is still unclear. Here we studied whether HLA-
Marja Ruuska +3 more
doaj +1 more source