Retrospective analysis of cutaneous immune-related adverse events following checkpoint inhibitor therapy in melanoma patients reveals increased risk associated with the HLA-B*51:01 allele. [PDF]
CancerABSTRACT Background While immune checkpoint inhibitors (ICIs) have shown significant efficacy, a common side effect is cutaneous immune‐related adverse events (irAEs). This study focuses on exploring the association between specific human leukocyte antigen (HLA) alleles and the development of cutaneous irAEs in melanoma patients undergoing ICI ...
DiLeo M +12 more
europepmc +2 more sources
Keratoscleritis and Choroidal Exudative Detachment in the Setting of Ocular Pyoderma Gangrenosum. [PDF]
Case Rep Ophthalmol MedPurpose The purpose of this study is to report a rare case of ocular pyoderma gangrenosum (PG) presenting as keratoscleritis with choroidal effusion following cataract surgery and to highlight its clinical recognition and management. Methods A 79‐year‐old man developed a corneal ulcer 2 days after uncomplicated phacoemulsification with intraocular lens
Bodeen J +3 more
europepmc +2 more sources
Nomenclature for Factors of the HLA System, 2026. [PDF]
HLAHLA, Volume 107, Issue 3, March 2026.
Marsh SGE +14 more
europepmc +2 more sources
Memory B-Cell Assay Uncovers Prior HLA Sensitisation in Transplant Candidates With Prior Exposure to Non-Self HLA. [PDF]
HLAABSTRACT Memory B cells are critical in kidney transplantation for rapid anti‐HLA antibody production upon re‐exposure, yet pretransplant serum antibodies often remain undetectable despite prior sensitisation. Using R848 stimulation (a TLR7/8 agonist inducing polyclonal B‐cell activation), we tested 45 kidney recipients with past sensitisation events ...
Altulea D +5 more
europepmc +2 more sources
deltaHED predicts survival and immune evasion in PD-1 blockade therapy: A multi-cohort study across three cancer types. [PDF]
Clin Transl MeddeltaHED predicts survival and immune evasion in PD‐1 blockade therapy: a multi‐cohort study across three cancer types. deltaHED quantifies germlinesomatic HLA‐I divergence and predicts survival and immune evasion in PD‐1 blockade therapy. Across nasopharyngeal carcinoma, melanoma, and esophageal squamous cell carcinoma, high deltaHED is associated ...
Xu J +10 more
europepmc +2 more sources
Behcet's Disease and Ankylosing Spondylitis: A Rare Association
Indian Journal of Medical Specialities, 2019 The overlap syndrome is frequently encountered in rheumatology, but the coexistence of Behçet's disease and ankylosing spondylitis is considered to be rare.
Amina Mounir +4 more
doaj +1 more source
Arthritis Research & Therapy, 2022 Background Behçet’s syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms. HLA-B51, as well as other genetic polymorphisms, has been reported to be associated with BS; however, the ...
Mai Okubo +16 more
doaj +1 more source
Pediatric Neurology Briefs, 1992 Of 4 children with idiopathic stroke syndrome examined at the Department of Neurosciences and Pediatrics, UMD-New Jersey Medical School and the University of Rochester Medical Center, all 4 were heterozygous for human leukocyte antigen (HLA-B51).
J Gordon Millichap
doaj +1 more source
Associations of HLA-A, -B and -DRB1 types with oral diseases in Swiss adults. [PDF]
PLoS ONE, 2014 Human leukocyte antigens (HLA) are crucial components of host defense against microbial challenge but the associations of HLA types with oral infectious diseases have not been studied in detail.
Matti Mauramo +5 more
doaj +1 more source
Behçet's disease: review with emphasis on dermatological aspects [PDF]
Anais Brasileiros de Dermatologia, 2017 : Behçet's disease is a systemic vasculitis characterized by attacks of acute inflammation, which can affect almost every vascularized area of the body. There is a close correlation between the geographical distribution of HLA-B51 and its prevalence.
Maria Antonieta Rios Scherrer +2 more
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