HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles [PDF]
Communications Biology, 2021 AbstractExtracellular vesicles can modulate diverse processes ranging from proliferation and tissue repair, to chemo-resistance and cellular differentiation. With the advent of tissue and immunological targeting, extracellular vesicles are also increasingly viewed as promising vectors to deliver peptide-based cancer antigens to the human immune system.
Julia Bauzá-Martinez +2 more
openaire +4 more sources
Evaluation of the humoral immune response to human leukocyte antigens in Brazilian renal transplant candidates. [PDF]
PLoS ONE, 2014 Pre-transplant sensitization to human leukocyte antigens (HLA) is a risk factor for graft failure. Studies of the immunological profile related to anti-HLA antibodies in Brazilian renal transplant candidates are few.
Patricia Keiko Saito +4 more
doaj +1 more source
Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]
, 1992 The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef +7 more
core +1 more source
The role of HLA-B27 in inflammatory arthritis [PDF]
, 2009 Redacted electronic version excludes material for which permission has not been granted by the rights holderThe MHC class I allele, HLA-B27, is strongly associated with a group of inflammatory arthritic conditions collectively known as ...
Lynch, Sarah Janice
core +2 more sources
Human Leukocyte Antigen (HLA) Frequencies and 4-loci HLA Haplotype Frequencies in Southern Thailand
Journal of Health Science and Medical Research (JHSMR)Objective: To determine the antigen and haplotype frequencies of human leukocyte antigen-A (HLA-A), -B, -DRB1, and -DQB1 in southern Thailand. Material and Methods: We retrospectively analyzed HLA typing data from patients treated at Songklanagarind ...
Kantarat Kusolthammarat +4 more
doaj +1 more source
Association of Alport's syndrome with HLA-DR2 antigen in a group of unrelated patients
Brazilian Journal of Medical and Biological Research, 1998 A few family studies have evaluated HLA antigens in Alport's syndrome; however, there are no large population studies. In the present report, we studied 40 unrelated white patients with Alport's syndrome seen at the Unit of Renal Transplantation, Faculty
E.A. Donadi +4 more
doaj +1 more source
Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity
eLife, 2018 The highly polymorphic human leukocyte antigen (HLA) class I molecules present peptide antigens to CD8+ T cells, inducing immunity against infections and cancers.
Brogan Yarzabek +9 more
doaj +1 more source
Immunodominant Tuberculosis CD8 Antigens Preferentially Restricted by HLA-B
PLoS Pathogens, 2007 CD8(+) T cells are essential for host defense to intracellular bacterial pathogens such as Mycobacterium tuberculosis (Mtb), Salmonella species, and Listeria monocytogenes, yet the repertoire and dominance pattern of human CD8 antigens for these pathogens remains poorly characterized.
Deborah A Lewinsohn +9 more
openaire +4 more sources
HLA-B Alleles Associated with the B15 Serologically Defined Antigens
Human Immunology, 1997 Cells expressing HLA molecules in the B15 family were identified by serologic typing in routine testing of volunteer donors of various ethnic backgrounds for a bone marrow registry. DNA sequencing was used to identify HLA-B15 alleles associated with each serologic type and to examine the diversity within the B15 antigen family.
N, Steiner +5 more
openaire +2 more sources
Frequency of Major Histocompatibility Antigens Class I in Mazandaran Province
Journal of Mazandaran University of Medical Sciences, 2022 Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran ...
Fatemeh Toghani Hulari +4 more
doaj